Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Science 19 July 1991:
Vol. 253. no. 5017, pp. 323 - 325
DOI: 10.1126/science.1857970
Prev | Table of Contents | Next

Articles

Science, Vol 253, Issue 5017, 323-325
Copyright © 1991 by American Association for the Advancement of Science

articles

Deposits of amyloid beta protein in the central nervous system of transgenic mice

DO Wirak, R Bayney, TV Ramabhadran, RP Fracasso, JT Hart, PE Hauer, P Hsiau, SK Pekar, GA Scangos, BD Trapp, and al. et

Molecular Therapeutics Inc., Miles Research Center, West Haven, CT 06516.

Alzheimer's disease is characterized by widespread deposition of amyloid in the central nervous system. The 4-kilodalton amyloid beta protein is derived from a larger amyloid precursor protein and forms amyloid deposits in the brain by an unknown pathological mechanism. Except for aged nonhuman primates, there is no animal model for Alzheimer's disease. Transgenic mice expressing amyloid beta protein in the brain could provide such a model. To investigate this possibility, the 4-kilodalton human amyloid beta protein was expressed under the control of the promoter of the human amyloid precursor protein in two lines of transgenic mice. Amyloid beta protein accumulated in the dendrites of some but not all hippocampal neurons in 1-year-old transgenic mice. Aggregates of the amyloid beta protein formed amyloid-like fibrils that are similar in appearance to those in the brains of patients with Alzheimer's disease.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Age-Dependent Neuronal and Synaptic Degeneration in Mice Transgenic for the C Terminus of the Amyloid Precursor Protein.
M. L. Oster-Granite, D. L. McPhie, J. Greenan, and R. L. Neve (1996)
J. Neurosci. 16, 6732-6741
   Abstract »    Full Text »    PDF »
Age-associated inclusions in normal and transgenic mouse brain.
M Jucker, L. Walker, L. Martin, C. Kitt, H. Kleinman, D. Ingram, and D. Price (1992)
Science 255, 1443-1445
   PDF »
Age-Associated Inclusions in Normal and Transgenic Mouse Brain.
D. WIRAK, R. BAYNEY, T. V. RAMABHADRAN, R. P. FRACASSO, J. T. HART, P. E. HAUER, P. HSIAU, S. K. PEKAR, G. A. SCANGOS, B. D. TRAPP, et al. (1992)
Science 255, 1445
   PDF »
Alzheimer's research moves to mice.
J Marx (1991)
Science 253, 266-267
   PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)