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Science 12 July 1991:
Vol. 253. no. 5016, pp. 199 - 202
DOI: 10.1126/science.1853205

Articles

Science, Vol 253, Issue 5016, 199-202
Copyright © 1991 by American Association for the Advancement of Science


articles

MHC class I deficiency: susceptibility to natural killer (NK) cells and impaired NK activity

NS Liao, M Bix, M Zijlstra, R Jaenisch, and D Raulet

Department of Molecular and Cell Biology, University of California, Berkeley 94720.

The role of major histocompatibility complex (MHC) class I expression in natural killer (NK) cell target recognition is controversial. Normal T cell blasts from MHC class I-deficient mutant mice were found to serve as target cells for NK cells in vitro, which suggests that MHC class I molecules are directly involved in NK cell recognition. Spleen cells from the mutant mice were deficient in their ability to lyse MHC class I-deficient target cells or NK-susceptible tumor targets, and mutant mice could not reject allogeneic bone marrow. Thus, class I molecules may participate in the positive selection or tolerance induction of NK cells.


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p46, a Novel Natural Killer Cell-specific Surface Molecule That Mediates Cell Activation.
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Natural Killer Cell Tolerance in Mice with Mosaic Expression of Major Histocompatibility Complex Class I Transgene.
M. H. Johansson, C. Bieberich, G. Jay, K. Karre, and P. Hoglund (1997)
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Ly49A Transgenic Mice Provide Evidence for a Major Histocompatibility Complex-dependent Education Process in Natural Killer Cell Development.
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The mother-child union: The case of missing-self and protection of the fetus.
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NKG2A Complexed with CD94 Defines a Novel Inhibitory Natural Killer Cell Receptor.
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J. Exp. Med. 185, 795-800
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Host F1 Mice Pretreated With Granulocyte Colony-Stimulating Factor Accept Parental Bone Marrow Grafts in Hybrid Resistance System.
K. Iizuka, H. Kaneko, T. Yamada, H. Kimura, Y. Kokai, and J. Fujimoto (1997)
Blood 89, 1446-1451
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Linkage of faulty major histocompatibility complex class I to autoimmune diabetes.
D Faustman, X. Li, H. Lin, Y. Fu, G Eisenbarth, J Avruch, and J Guo (1991)
Science 254, 1756-1761
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Science. ISSN 0036-8075 (print), 1095-9203 (online)