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Science 28 June 1991:
Vol. 252. no. 5014, pp. 1848 - 1851
DOI: 10.1126/science.2063198
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Articles

Science, Vol 252, Issue 5014, 1848-1851
Copyright © 1991 by American Association for the Advancement of Science

articles

A corticosteroid receptor in neuronal membranes

M Orchinik, TF Murray, and FL Moore

Department of Zoology, Oregon State University, Corvallis 97331.

Steroids may rapidly alter neuronal function and behavior through poorly characterized, direct actions on neuronal membranes. The membrane-bound receptors mediating these behavioral responses have not been identified. [3H]Corticosterone labels a population of specific, high-affinity recognition sites (dissociation constant = 0.51 nanomolar) in synaptic membranes from an amphibian brain. These binding sites were localized by receptor autoradiography in the neuropil, outside the regions of perikarya. The affinities of corticoids for this [3H]corticosterone binding site were linearly related to their potencies in rapidly suppressing male reproductive behavior. Thus, it appears that brain membranes contain a corticosteroid receptor that could participate in the regulation of behavior.


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