Science 28 June 1991: Vol. 252. no. 5014, pp. 1817 - 1822 DOI: 10.1126/science.2063194

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Articles

Semisynthesis and segmental isotope labeling of the apoE3 N-terminal domain using expressed protein ligation.

P. S. Hauser, V. Raussens, T. Yamamoto, G. E. Abdullahi, P. M. M. Weers, B. D. Sykes, and R. O. Ryan (2009)
J. Lipid Res. 50, 1548-1555
 |  Abstract »  |  Full Text »  |  PDF »

A Unified Scheme for Initiation and Conformational Adaptation of Human Apolipoprotein E N-terminal Domain upon Lipoprotein Binding and for Receptor Binding Activity.

A. Sivashanmugam and J. Wang (2009)
J. Biol. Chem. 284, 14657-14666
 |  Abstract »  |  Full Text »  |  PDF »

Apolipoprotein E: structure determines function, from atherosclerosis to Alzheimer's disease to AIDS.

R. W. Mahley, K. H. Weisgraber, and Y. Huang (2009)
J. Lipid Res. 50, S183-S188
 |  Abstract »  |  Full Text »  |  PDF »

Understanding the Association of Apolipoprotein E4 with Alzheimer Disease: Clues from Its Structure.

N. Zhong and K. H. Weisgraber (2009)
J. Biol. Chem. 284, 6027-6031
 |  Abstract »  |  Full Text »  |  PDF »

Dendritic Cell Differentiation Induced by a Self-Peptide Derived from Apolipoprotein E.

T. A. Stephens, E. Nikoopour, B. J. Rider, M. Leon-Ponte, T. A. Chau, S. Mikolajczak, P. Chaturvedi, E. Lee-Chan, R. A. Flavell, S. M. M. Haeryfar, et al. (2008)
J. Immunol. 181, 6859-6871
 |  Abstract »  |  Full Text »  |  PDF »

Three-dimensional models of HDL apoA-I: implications for its assembly and function.

M. J. Thomas, S. Bhat, and M. G. Sorci-Thomas (2008)
J. Lipid Res. 49, 1875-1883
 |  Abstract »  |  Full Text »  |  PDF »

Quantifying size distributions of nanolipoprotein particles with single-particle analysis and molecular dynamic simulations.

C. D. Blanchette, R. Law, W. H. Benner, J. B. Pesavento, J. A. Cappuccio, V. Walsworth, E. A. Kuhn, M. Corzett, B. A. Chromy, B. W. Segelke, et al. (2008)
J. Lipid Res. 49, 1420-1430
 |  Abstract »  |  Full Text »  |  PDF »

Structure and Dynamics of Human Apolipoprotein CIII.

C. S. Gangabadage, J. Zdunek, M. Tessari, S. Nilsson, G. Olivecrona, and S. S. Wijmenga (2008)
J. Biol. Chem. 283, 17416-17427
 |  Abstract »  |  Full Text »  |  PDF »

A Three-dimensional Homology Model of Lipid-free Apolipoprotein A-IV Using Cross-linking and Mass Spectrometry.

M. R. Tubb, R. A. G. D. Silva, J. Fang, P. Tso, and W. S. Davidson (2008)
J. Biol. Chem. 283, 17314-17323
 |  Abstract »  |  Full Text »  |  PDF »

Structural Basis for the Recognition and Cross-linking of Amyloid Fibrils by Human Apolipoprotein E.

M. J. Gunzburg, M. A. Perugini, and G. J. Howlett (2007)
J. Biol. Chem. 282, 35831-35841
 |  Abstract »  |  Full Text »  |  PDF »

The Structure of Apolipoprotein A-I in High Density Lipoproteins.

W. S. Davidson and T. B. Thompson (2007)
J. Biol. Chem. 282, 22249-22253
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The C Terminus of Apolipoprotein A-V Modulates Lipid-binding Activity.

J. A. Beckstead, K. Wong, V. Gupta, C.-P. L. Wan, V. R. Cook, R. B. Weinberg, P. M. M. Weers, and R. O. Ryan (2007)
J. Biol. Chem. 282, 15484-15489
 |  Abstract »  |  Full Text »  |  PDF »

Apolipoprotein E*dipalmitoylphosphatidylcholine particles are ellipsoidal in solution.

C. A. Peters-Libeu, Y. Newhouse, S. C. Hall, H. E. Witkowska, and K. H. Weisgraber (2007)
J. Lipid Res. 48, 1035-1044
 |  Abstract »  |  Full Text »  |  PDF »

Lipid-induced Extension of Apolipoprotein E Helix 4 Correlates with Low Density Lipoprotein Receptor Binding Ability.

V. Gupta, V. Narayanaswami, M. S. Budamagunta, T. Yamamato, J. C. Voss, and R. O. Ryan (2006)
J. Biol. Chem. 281, 39294-39299
 |  Abstract »  |  Full Text »  |  PDF »

C-terminal interactions of apolipoprotein E4 respond to the postprandial state.

S. D. Tetali, M. S. Budamagunta, J. C. Voss, and J. C. Rutledge (2006)
J. Lipid Res. 47, 1358-1365
 |  Abstract »  |  Full Text »  |  PDF »

Structural and Functional Variations in Human Apolipoprotein E3 and E4.

C.-Y. Chou, W.-P. Jen, Y.-H. Hsieh, M.-S. Shiao, and G.-G. Chang (2006)
J. Biol. Chem. 281, 13333-13344
 |  Abstract »  |  Full Text »  |  PDF »

Characterization of low density lipoprotein receptor ligand interactions by fluorescence resonance energy transfer.

T. Yamamoto, J. Lamoureux, and R. O. Ryan (2006)
J. Lipid Res. 47, 1091-1096
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Inaugural Article: Apolipoprotein E4: A causative factor and therapeutic target in neuropathology, including Alzheimer's disease.

R. W. Mahley, K. H. Weisgraber, and Y. Huang (2006)
PNAS 103, 5644-5651
 |  Abstract »  |  Full Text »  |  PDF »

Profile of Robert W. Mahley.

R. Nuzzo (2006)
PNAS 103, 5641-5643
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Crystal structure of human apolipoprotein A-I: Insights into its protective effect against cardiovascular diseases.

A. A. Ajees, G. M. Anantharamaiah, V. K. Mishra, M. M. Hussain, and H. M. K. Murthy (2006)
PNAS 103, 2126-2131
 |  Abstract »  |  Full Text »  |  PDF »

Model of Biologically Active Apolipoprotein E Bound to Dipalmitoylphosphatidylcholine.

C. A. Peters-Libeu, Y. Newhouse, D. M. Hatters, and K. H. Weisgraber (2006)
J. Biol. Chem. 281, 1073-1079
 |  Abstract »  |  Full Text »  |  PDF »

Evaluation of Tributyrin Lipid Emulsion with Affinity to Low-Density Lipoprotein: Pharmacokinetics in Adult Male Wistar Rats and Cellular Activity on Caco-2 and HepG2 Cell Lines.

J. Su, L. He, N. Zhang, and P. C. Ho (2006)
J. Pharmacol. Exp. Ther. 316, 62-70
 |  Abstract »  |  Full Text »  |  PDF »

Apolipoprotein (apo) E4 enhances amyloid {beta} peptide production in cultured neuronal cells: ApoE structure as a potential therapeutic target.

S. Ye, Y. Huang, K. Mullendorff, L. Dong, G. Giedt, E. C. Meng, F. E. Cohen, I. D. Kuntz, K. H. Weisgraber, and R. W. Mahley (2005)
PNAS 102, 18700-18705
 |  Abstract »  |  Full Text »  |  PDF »

Rerouting lipoprotein nanoparticles to selected alternate receptors for the targeted delivery of cancer diagnostic and therapeutic agents.

G. Zheng, J. Chen, H. Li, and J. D. Glickson (2005)
PNAS 102, 17757-17762
 |  Abstract »  |  Full Text »  |  PDF »

Specific Sequences in the N and C Termini of Apolipoprotein A-IV Modulate Its Conformation and Lipid Association.

K. Pearson, M. R. Tubb, M. Tanaka, X. Q. Zhang, P. Tso, R. B. Weinberg, and W. S. Davidson (2005)
J. Biol. Chem. 280, 38576-38582
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Modulation of Apolipoprotein E Structure by Domain Interaction: DIFFERENCES IN LIPID-BOUND AND LIPID-FREE FORMS.

D. M. Hatters, M. S. Budamagunta, J. C. Voss, and K. H. Weisgraber (2005)
J. Biol. Chem. 280, 34288-34295
 |  Abstract »  |  Full Text »  |  PDF »

Intermolecular Contact between Globular N-terminal Fold and C-terminal Domain of ApoA-I Stabilizes Its Lipid-bound Conformation: STUDIES EMPLOYING CHEMICAL CROSS-LINKING AND MASS SPECTROMETRY.

S. Bhat, M. G. Sorci-Thomas, E. T. Alexander, M. P. Samuel, and M. J. Thomas (2005)
J. Biol. Chem. 280, 33015-33025
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Sense and antisense transcripts of the apolipoprotein E gene in normal and ApoE knockout mice, their expression after spinal cord injury and corresponding human transcripts.

A. Seitz, D. Gourevitch, X.-M. Zhang, L. Clark, P. Chen, M. Kragol, N. Levenkova, J. Rux, S. Samulewicz, and E. Heber-Katz (2005)
Hum. Mol. Genet. 14, 2661-2670
 |  Abstract »  |  Full Text »  |  PDF »

Engineering Conformational Destabilization into Mouse Apolipoprotein E: A MODEL FOR A UNIQUE PROPERTY OF HUMAN APOLIPOPROTEIN E4.

D. M. Hatters, C. A. Peters-Libeu, and K. H. Weisgraber (2005)
J. Biol. Chem. 280, 26477-26482
 |  Abstract »  |  Full Text »  |  PDF »

Examination of Lipid-bound Conformation of Apolipoprotein E4 by Pyrene Excimer Fluorescence.

J. Drury and V. Narayanaswami (2005)
J. Biol. Chem. 280, 14605-14610
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Two-step Mechanism of Binding of Apolipoprotein E to Heparin: IMPLICATIONS FOR THE KINETICS OF APOLIPOPROTEIN E-HEPARAN SULFATE PROTEOGLYCAN COMPLEX FORMATION ON CELL SURFACES.

M. Futamura, P. Dhanasekaran, T. Handa, M. C. Phillips, S. Lund-Katz, and H. Saito (2005)
J. Biol. Chem. 280, 5414-5422
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The Role of a Conserved Acidic Residue in Calcium-dependent Protein Folding for a Low Density Lipoprotein (LDL)-A Module: IMPLICATIONS IN STRUCTURE AND FUNCTION FOR THE LDL RECEPTOR SUPERFAMILY.

Y. Guo, X. Yu, K. Rihani, Q.-Y. Wang, and L. Rong (2004)
J. Biol. Chem. 279, 16629-16637
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Helix Orientation of the Functional Domains in Apolipoprotein E in Discoidal High Density Lipoprotein Particles.

V. Narayanaswami, J. N. Maiorano, P. Dhanasekaran, R. O. Ryan, M. C. Phillips, S. Lund-Katz, and W. S. Davidson (2004)
J. Biol. Chem. 279, 14273-14279
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NMR Solution Structure of the Focal Adhesion Targeting Domain of Focal Adhesion Kinase in Complex with a Paxillin LD Peptide: EVIDENCE FOR A TWO-SITE BINDING MODEL.

G. Gao, K. C. Prutzman, M. L. King, D. M. Scheswohl, E. F. DeRose, R. E. London, M. D. Schaller, and S. L. Campbell (2004)
J. Biol. Chem. 279, 8441-8451
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Effects of Polymorphism on the Lipid Interaction of Human Apolipoprotein E.

H. Saito, P. Dhanasekaran, F. Baldwin, K. H. Weisgraber, M. C. Phillips, and S. Lund-Katz (2003)
J. Biol. Chem. 278, 40723-40729
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Lipid-bound Structure of an Apolipoprotein E-derived Peptide.

V. Raussens, C. M. Slupsky, B. D. Sykes, and R. O. Ryan (2003)
J. Biol. Chem. 278, 25998-26006
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Kinetic Analysis of Binding Interaction between the Subgroup A Rous Sarcoma Virus Glycoprotein SU and Its Cognate Receptor Tva: Calcium Is Not Required for Ligand Binding.

X. Yu, Q.-Y. Wang, Y. Guo, K. Dolmer, J. A. T. Young, P. G. W. Gettins, and L. Rong (2003)
J. Virol. 77, 7517-7526
 |  Abstract »  |  Full Text »  |  PDF »

Domain Structure and Lipid Interaction in Human Apolipoproteins A-I and E, a General Model.

H. Saito, P. Dhanasekaran, D. Nguyen, P. Holvoet, S. Lund-Katz, and M. C. Phillips (2003)
J. Biol. Chem. 278, 23227-23232
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Sequence and Structure of Human Rhinoviruses Reveal the Basis of Receptor Discrimination.

M. Vlasak, S. Blomqvist, T. Hovi, E. Hewat, and D. Blaas (2003)
J. Virol. 77, 6923-6930
 |  Abstract »  |  Full Text »  |  PDF »

Structure-guided Protein Engineering Modulates Helix Bundle Exchangeable Apolipoprotein Properties.

R. S. Kiss, P. M. M. Weers, V. Narayanaswami, J. Cohen, C. M. Kay, and R. O. Ryan (2003)
J. Biol. Chem. 278, 21952-21959
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NMR Solution Structure and Dynamics of an Exchangeable Apolipoprotein, Locusta migratoria Apolipophorin III.

D. Fan, Y. Zheng, D. Yang, and J. Wang (2003)
J. Biol. Chem. 278, 21212-21220
 |  Abstract »  |  Full Text »  |  PDF »

Characterization of the Heparin Binding Sites in Human Apolipoprotein E.

H. Saito, P. Dhanasekaran, D. Nguyen, F. Baldwin, K. H. Weisgraber, S. Wehrli, M. C. Phillips, and S. Lund-Katz (2003)
J. Biol. Chem. 278, 14782-14787
 |  Abstract »  |  Full Text »  |  PDF »

Apolipoprotein E4 Forms a Molten Globule. A POTENTIAL BASIS FOR ITS ASSOCIATION WITH DISEASE.

J. A. Morrow, D. M. Hatters, B. Lu, P. Hochtl, K. A. Oberg, B. Rupp, and K. H. Weisgraber (2002)
J. Biol. Chem. 277, 50380-50385
 |  Abstract »  |  Full Text »  |  PDF »

Influence of apoE domain structure and polymorphism on the kinetics of phospholipid vesicle solubilization.

M. L. Segall, P. Dhanasekaran, F. Baldwin, G. M. Anantharamaiah, K. H. Weisgraber, M. C. Phillips, and S. Lund-Katz (2002)
J. Lipid Res. 43, 1688-1700
 |  Abstract »  |  Full Text »  |  PDF »

NMR Structure and Dynamics of a Receptor-active Apolipoprotein E Peptide.

V. Raussens, C. M. Slupsky, R. O. Ryan, and B. D. Sykes (2002)
J. Biol. Chem. 277, 29172-29180
 |  Abstract »  |  Full Text »  |  PDF »

Structural Insight into the Mechanisms of Targeting and Signaling of Focal Adhesion Kinase.

G. Liu, C. D. Guibao, and J. Zheng (2002)
Mol. Cell. Biol. 22, 2751-2760
 |  Abstract »  |  Full Text »  |  PDF »

Effects of polymorphism on the microenvironment of the LDL receptor-binding region of human apoE.

S. Lund-Katz, S. Wehrli, M. Zaiou, Y. Newhouse, K. H. Weisgraber, and M. C. Phillips (2001)
J. Lipid Res. 42, 894-901
 |  Abstract »  |  Full Text »

Cationic domain 141-150 of apoE covalently linked to a class A amphipathic helix enhances atherogenic lipoprotein metabolism in vitro and in vivo.

G. Datta, D. W. Garber, B. H. Chung, M. Chaddha, N. Dashti, W. A. Bradley, S. H. Gianturco, and G. M. Anantharamaiah (2001)
J. Lipid Res. 42, 959-966
 |  Abstract »  |  Full Text »

Identification of Key Residues in Subgroup A Avian Leukosis Virus Envelope Determining Receptor Binding Affinity and Infectivity of Cells Expressing Chicken or Quail Tva Receptor.

S. L. Holmen, D. C. Melder, and M. J. Federspiel (2001)
J. Virol. 75, 726-737
 |  Abstract »  |  Full Text »

The APO*E3-Leiden mouse as an animal model for basal laminar deposit.

M. Kliffen, E. Lutgens, M. J A P Daemen, E. D de Muinck, C. M Mooy, and P. T V M de Jong (2000)
Br J Ophthalmol 84, 1415-1419
 |  Abstract »  |  Full Text »

Neuronal Apoptosis by Apolipoprotein E4 through Low-Density Lipoprotein Receptor-Related Protein and Heterotrimeric GTPases.

Y. Hashimoto, H. Jiang, T. Niikura, Y. Ito, A. Hagiwara, K. Umezawa, Y. Abe, Y. Murayama, and I. Nishimoto (2000)
J. Neurosci. 20, 8401-8409
 |  Abstract »  |  Full Text »  |  PDF »

Intramuscular injection of a plasmid vector expressing human apolipoprotein E limits progression of xanthoma and aortic atheroma in apoE-deficient mice.

T. Athanasopoulos, J. S. Owen, D. Hassall, M. G. Dunckley, J. Drew, J. Goodman, A. D. Tagalakis, D. R. Riddell, and G. Dickson (2000)
Hum. Mol. Genet. 9, 2545-2551
 |  Abstract »  |  Full Text »  |  PDF »

Apolipoprotein E;-low density lipoprotein receptor interaction: influences of basic residue and amphipathic {alpha}-helix organization in the ligand.

M. Zaiou, K. S. Arnold, Y. M. Newhouse, T. L. Innerarity, K. H. Weisgraber, M. L. Segall, M. C. Phillips, and S. Lund-Katz (2000)
J. Lipid Res. 41, 1087-1095
 |  Abstract »  |  Full Text »

Apolipoprotein E2 (Lys146->Gln) Causes Hypertriglyceridemia due to an Apolipoprotein E Variant-Specific Inhibition of Lipolysis of Very Low Density Lipoproteins-Triglycerides.

F. de Beer, K. W. van Dijk, M. C. Jong, L. C. van Vark, A. van der Zee, M. H. Hofker, F. J. Fallaux, R. C. Hoeben, A. H. M. Smelt, and L. M. Havekes (2000)
Arterioscler Thromb Vasc Biol 20, 1800-1806
 |  Abstract »  |  Full Text »  |  PDF »

Apolipoprotein A-I: structure;-function relationships.

P. G. Frank and Y. L. Marcel (2000)
J. Lipid Res. 41, 853-872
 |  Abstract »  |  Full Text »

Binding of an Antibody Mimetic of the Human Low Density Lipoprotein Receptor to Apolipoprotein E Is Governed through Electrostatic Forces. STUDIES USING SITE-DIRECTED MUTAGENESIS AND MOLECULAR MODELING.

R. Raffai, K. H. Weisgraber, R. MacKenzie, B. Rupp, E. Rassart, T. Hirama, T. L. Innerarity, and R. Milne (2000)
J. Biol. Chem. 275, 7109-7116
 |  Abstract »  |  Full Text »  |  PDF »

Interaction of locust apolipophorin III with lipoproteins and phospholipid vesicles: effect of glycosylation.

P. M. M. Weers, D. J. Van der Horst, and R. O. Ryan (2000)
J. Lipid Res. 41, 416-423
 |  Abstract »  |  Full Text »

NMR Solution Structure of Complement-like Repeat CR3 from the Low Density Lipoprotein Receptor-related Protein. EVIDENCE FOR SPECIFIC BINDING TO THE RECEPTOR BINDING DOMAIN OF HUMAN alpha 2-MACROGLOBULIN.

K. Dolmer, W. Huang, and P. G. W. Gettins (2000)
J. Biol. Chem. 275, 3264-3269
 |  Abstract »  |  Full Text »  |  PDF »

Effect of Arginine 172 on the Binding of Apolipoprotein E to the Low Density Lipoprotein Receptor.

J. A. Morrow, K. S. Arnold, J. Dong, M. E. Balestra, T. L. Innerarity, and K. H. Weisgraber (2000)
J. Biol. Chem. 275, 2576-2580
 |  Abstract »  |  Full Text »  |  PDF »

NMR Solution Structure of the Receptor Binding Domain of Human alpha 2-Macroglobulin.

W. Huang, K. Dolmer, X. Liao, and P. G. W. Gettins (2000)
J. Biol. Chem. 275, 1089-1094
 |  Abstract »  |  Full Text »  |  PDF »

Pathogenesis of type III hyperlipoproteinemia (dysbetalipoproteinemia): questions, quandaries, and paradoxes.

R. W. Mahley, Y. Huang, and S. C. Rall , Jr. (1999)
J. Lipid Res. 40, 1933-1949
 |  Abstract »  |  Full Text »

Identification of a Heparin-binding Region of Rat Thyroglobulin Involved in Megalin Binding.

M. Marino, J. A. Friedlander, R. T. McCluskey, and D. Andrews (1999)
J. Biol. Chem. 274, 30377-30386
 |  Abstract »  |  Full Text »  |  PDF »

Interaction of an Exchangeable Apolipoprotein with Phospholipid Vesicles and Lipoprotein Particles. ROLE OF LEUCINES 32, 34, AND 95 IN LOCUSTA MIGRATORIA APOLIPOPHORIN III.

P. M. M. Weers, V. Narayanaswami, C. M. Kay, and R. O. Ryan (1999)
J. Biol. Chem. 274, 21804-21810
 |  Abstract »  |  Full Text »  |  PDF »

Structural characterization by computer experiments of the lipid-free LDL-receptor-binding domain of apolipoprotein E.

M. Prevost and J.-P. Kocher (1999)
Protein Eng. Des. Sel. 12, 475-483
 |  Abstract »  |  Full Text »  |  PDF »

NMR Solution Structure of Complement-like Repeat CR8 from the Low Density Lipoprotein Receptor-related Protein.

W. Huang, K. Dolmer, and P. G. W. Gettins (1999)
J. Biol. Chem. 274, 14130-14136
 |  Abstract »  |  Full Text »  |  PDF »

Effects of a Frequent Apolipoprotein E Isoform, ApoE4Freiburg (Leu28->Pro), on Lipoproteins and the Prevalence of Coronary Artery Disease in Whites.

M. Orth, W. Weng, H. Funke, A. Steinmetz, G. Assmann, M. Nauck, J. Dierkes, A. Ambrosch, K. H. Weisgraber, R. W. Mahley, et al. (1999)
Arterioscler Thromb Vasc Biol 19, 1306-1315
 |  Abstract »  |  Full Text »  |  PDF »

A molecular trigger of lipid binding-induced opening of a helix bundle exchangeable apolipoprotein.

V. Narayanaswami, J. Wang, D. Schieve, C. M. Kay, and R. O. Ryan (1999)
PNAS 96, 4366-4371
 |  Abstract »  |  Full Text »  |  PDF »

Peptide model of a highly conserved, N-terminal domain of apolipoprotein E is able to modulate lipoprotein binding to a member of the class A scavenger receptor family.

S. R. Dominguez, H. Miller-Auer, C. A. Reardon, and S. C. Meredith (1999)
J. Lipid Res. 40, 753-763
 |  Abstract »  |  Full Text »

Apolipoprotein-mediated Plasma Membrane Microsolubilization. ROLE OF LIPID AFFINITY AND MEMBRANE PENETRATION IN THE EFFLUX OF CELLULAR CHOLESTEROL AND PHOSPHOLIPID.

K. L. Gillotte, M. Zaiou, S. Lund-Katz, G. M. Anantharamaiah, P. Holvoet, A. Dhoest, M. N. Palgunachari, J. P. Segrest, K. H. Weisgraber, G. H. Rothblat, et al. (1999)
J. Biol. Chem. 274, 2021-2028
 |  Abstract »  |  Full Text »  |  PDF »

Lipid binding-induced conformational changes in the N-terminal domain of human apolipoprotein E.

C. A. Fisher and R. O. Ryan (1999)
J. Lipid Res. 40, 93-99
 |  Abstract »  |  Full Text »

A Novel Amyloidogenic Variant of Apolipoprotein AI : Implications for a Conformational Change Leading to Cardiomyopathy.

M. T. Walsh (1999)
Am. J. Pathol. 154, 11-14
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The Low Density Lipoprotein Receptor Active Conformation of Apolipoprotein E. HELIX ORGANIZATION IN N-TERMINAL DOMAIN-PHOSPHOLIPID DISC PARTICLES.

V. Raussens, C. A. Fisher, E. Goormaghtigh, R. O. Ryan, and J.-M. Ruysschaert (1998)
J. Biol. Chem. 273, 25825-25830
 |  Abstract »  |  Full Text »  |  PDF »

The Domain Structure of Human Receptor-associated Protein. PROTEASE SENSITIVITY AND GUANIDINE HCl DENATURATION.

S. C. Rall Jr., P. Ye, G. Bu, and M. R. Wardell (1998)
J. Biol. Chem. 273, 24152-24157
 |  Abstract »  |  Full Text »  |  PDF »

The carboxyl terminus in apolipoprotein E2 and the seven amino acid repeat in apolipoprotein E-Leiden: role in receptor-binding activity.

L.-M. Dong, T. L. Innerarity, K. S. Arnold, Y. M. Newhouse, and K. H. Weisgraber (1998)
J. Lipid Res. 39, 1173-1180
 |  Abstract »  |  Full Text »

The Hydrophobic Face Orientation of Apolipoprotein A-I Amphipathic Helix Domain 143-164 Regulates Lecithin:Cholesterol Acyltransferase Activation.

M. G. Sorci-Thomas, L. Curtiss, J. S. Parks, M. J. Thomas, M. W. Kearns, and M. Landrum (1998)
J. Biol. Chem. 273, 11776-11782
 |  Abstract »  |  Full Text »  |  PDF »

Apolipoprotein E2 (Arg136 -> Cys) mutation in the receptor binding domain of apoE is not associated with dominant type III hyperlipoproteinemia.

W. März, M. M. Hoffmann, H. Scharnagl, E. Fisher, M. Chen, M. Nauck, G. Feussner, and H. Wieland (1998)
J. Lipid Res. 39, 658-669
 |  Abstract »  |  Full Text »

The atomic model of the human protective protein/cathepsin A suggests a structural basis for galactosialidosis.

G. Rudenko, E. Bonten, Wim. G. J. Hol, and A. d'Azzo (1998)
PNAS 95, 621-625
 |  Abstract »  |  Full Text »  |  PDF »

Apolipoprotein B-100: conservation of lipid-associating amphipathic secondary structural motifs in nine species of vertebrates.

J. P. Segrest, M. K. Jones, V. K. Mishra, V. Pierotti, S. H. Young, J. Borén, T. L. Innerarity, and N. Dashti (1998)
J. Lipid Res. 39, 85-102
 |  Abstract »  |  Full Text »

Human Low Density Lipoprotein Receptor Fragment. SUCCESSFUL REFOLDING OF A FUNCTIONALLY ACTIVE LIGAND-BINDING DOMAIN PRODUCED IN ESCHERICHIA COLI.

T. Simmons, Y. M. Newhouse, K. S. Arnold, T. L. Innerarity, and K. H. Weisgraber (1997)
J. Biol. Chem. 272, 25531-25536
 |  Abstract »  |  Full Text »  |  PDF »

Human Recombinant Apolipoprotein E-Enriched Liposomes Can Mimic Low-Density Lipoproteins as Carriers for the Site-Specific Delivery of Antitumor Agents.

P. C. N. Rensen, R. M. Schiffelers, A. J. Versluis, M. K. Bijsterbosch, M. E. M. J. Van Kuijk-Meuwissen, and T. J. C. Van Berkel (1997)
Mol. Pharmacol. 52, 445-455
 |  Abstract »  |  Full Text »

Apolipoprotein E Binds to and Potentiates the Biological Activity of Ciliary Neurotrophic Factor.

C. R. Gutman, W. J. Strittmatter, K. H. Weisgraber, and W. D. Matthew (1997)
J. Neurosci. 17, 6114-6121
 |  Abstract »  |  Full Text »  |  PDF »

Both apolipoprotein E and A-I genes are present in a nonmammalian vertebrate and are highly expressed during embryonic development.

P. J. Babin, C. Thisse, M. Durliat, M. Andre, M.-A. Akimenko, and B. Thisse (1997)
PNAS 94, 8622-8627
 |  Abstract »  |  Full Text »  |  PDF »

Insight into Lipid Surface Recognition and Reversible Conformational Adaptations of an Exchangeable Apolipoprotein by Multidimensional Heteronuclear NMR Techniques.

J. Wang, S. M. Gagne, B. D. Sykes, and R. O. Ryan (1997)
J. Biol. Chem. 272, 17912-17920
 |  Abstract »  |  Full Text »  |  PDF »

The Carboxyl-terminal Hydrophobic Residues of Apolipoprotein A-I Affect Its Rate of Phospholipid Binding and Its Association with High Density Lipoprotein.

M. Laccotripe, S. C. Makrides, A. Jonas, and V. I. Zannis (1997)
J. Biol. Chem. 272, 17511-17522
 |  Abstract »  |  Full Text »  |  PDF »

The Apolipoprotein E2(Arg145Cys) Mutation Causes Autosomal Dominant Type III Hyperlipoproteinemia With Incomplete Penetrance.

W. J.S. de Villiers, D. R. van der Westhuyzen, G. A. Coetzee, H. E. Henderson, and A. D. Marais (1997)
Arterioscler Thromb Vasc Biol 17, 865-872
 |  Abstract »  |  Full Text »

alpha -Helical Protein Assembly Motifs.

W. D. Kohn, C. T. Mant, and R. S. Hodges (1997)
J. Biol. Chem. 272, 2583-2586
 |  Full Text »  |  PDF »

Possible Functional Interactions of Apolipoprotein B-100 Segments That Associate With Cell Proteoglycans and the ApoB/E Receptor.

U. Olsson, G. Camejo, E. Hurt-Camejo, K. Elfsber, O. Wiklund, and G. Bondjers (1997)
Arterioscler Thromb Vasc Biol 17, 149-155
 |  Abstract »  |  Full Text »

The role of apolipoprotein AI domains in lipid binding.

W. S. Davidson, T. Hazlett, W. W. Mantulin, and A. Jonas (1996)
PNAS 93, 13605-13610
 |  Abstract »  |  Full Text »  |  PDF »

Disulfide Bond Engineering to Monitor Conformational Opening of Apolipophorin III During Lipid Binding.

V. Narayanaswami, J. Wang, C. M. Kay, D. G. Scraba, and R. O. Ryan (1996)
J. Biol. Chem. 271, 26855-26862
 |  Abstract »  |  Full Text »  |  PDF »

Apolipoprotein A-I Conformation in Reconstituted Discoidal Lipoproteins Varying in Phospholipid and Cholesterol Content.

J. Bergeron, P. G. Frank, D. Scales, Q.-H. Meng, G. Castro, and Y. L. Marcel (1995)
J. Biol. Chem. 270, 27429-27438
 |  Abstract »  |  Full Text »  |  PDF »

An Antibody Fragment from a Phage Display Library Competes for Ligand Binding to the Low Density Lipoprotein Receptor Family and Inhibits Rhinovirus Infection.

R. A. Hodits, J. Nimpf, D. M. Pfistermueller, T. Hiesberger, W. J. Schneider, T. J. Vaughan, K. S. Johnson, M. Haumer, E. Kuechler, G. Winter, et al. (1995)
J. Biol. Chem. 270, 24078-24085
 |  Abstract »  |  Full Text »  |  PDF »

Apolipoprotein E Carboxyl-terminal Fragments Are Complexed to Amyloids A and L.

E. M. Castao, F. Prelli, M. Pras, and B. Frangione (1995)
J. Biol. Chem. 270, 17610-17615
 |  Abstract »  |  Full Text »  |  PDF »

The crystal structure of lysin, a fertilization protein.

A Shaw, D. McRee, V. Vacquier, and C. Stout (1993)
Science 262, 1864-1867
 |  Abstract »  |  PDF »

Receptors and Transmembrane Signaling.

B.L. Stoddard, H.-P. Biemann, and D.E. Koshland Jr. (1992)
Cold Spring Harb Symp Quant Biol 57, 1-15
 |  Abstract »  |  PDF »

Three-dimensional structures of the ligand-binding domain of the bacterial aspartate receptor with and without a ligand.

M. Milburn, G. Prive, D. Milligan, W. Scott, J Yeh, J Jancarik, D. Koshland Jr, and S. Kim (1991)
Science 254, 1342-1347
 |  Abstract »  |  PDF »

The Lipid-associated Conformation of the Low Density Lipoprotein Receptor Binding Domain of Human Apolipoprotein E.

C. A. Fisher, V. Narayanaswami, and R. O. Ryan (2000)
J. Biol. Chem. 275, 33601-33606
 |  Abstract »  |  Full Text »  |  PDF »

Conformational Reorganization of the Four-helix Bundle of Human Apolipoprotein E in Binding to Phospholipid.

B. Lu, J. A. Morrow, and K. H. Weisgraber (2000)
J. Biol. Chem. 275, 20775-20781
 |  Abstract »  |  Full Text »  |  PDF »

Self-association of Human Apolipoprotein E3 and E4 in the Presence and Absence of Phospholipid.

M. A. Perugini, P. Schuck, and G. J. Howlett (2000)
J. Biol. Chem. 275, 36758-36765
 |  Abstract »  |  Full Text »  |  PDF »

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