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Science 21 June 1991:
Vol. 252. no. 5013, pp. 1703 - 1705
DOI: 10.1126/science.1904628
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Articles

Science, Vol 252, Issue 5013, 1703-1705
Copyright © 1991 by American Association for the Advancement of Science

articles

Selective elimination of HIV-1-infected cells with an interleukin-2 receptor-specific cytotoxin

RW Finberg, SM Wahl, JB Allen, G Soman, TB Strom, Murphy JR, and JC Nichols

Laboratory of Infectious Diseases, Dana-Farber Cancer Institute, Boston, MA.

Infection by human immunodeficiency virus type 1 (HIV-1) is associated with cellular activation and expression of the interleukin-2 (IL-2) receptor. A genetically engineered fusion toxin, DAB486 IL-2, that contains the enzymatic site and translocation domain of diphtheria toxin and the receptor binding domain of IL-2 specifically kills cells that express high-affinity IL-2 receptors. This toxin selectively eliminated the HIV-1-infected cells from mixed cultures of infected and uninfected cells and inhibited production of viral proteins and infectious virus. Thus, cellular activation antigens present a target for early antiviral intervention.


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Inhibition of Human Immunodeficiency Virus Type 1 Infectivity by Secretory Leukocyte Protease Inhibitor Occurs Prior to Viral Reverse Transcription.
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NOVEL HYBRID MOLECULE SELECTIVELY HITS HIV-INFECTED CELLS.
(1991)
Journal Watch (General) 1991, 7
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