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Science 21 June 1991:
Vol. 252. no. 5013, pp. 1657 - 1662
DOI: 10.1126/science.2047874
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Articles

Science, Vol 252, Issue 5013, 1657-1662
Copyright © 1991 by American Association for the Advancement of Science

articles

Monoclonal antibodies in diagnosis and therapy

TA Waldmann

Metabolism Branch, National Cancer Institute, National Institute of Health, Bethesda, MD 20892.

Monoclonal antibodies have been applied clinically to the diagnosis and therapy of an array of human disorders, including cancer and infectious diseases, and have been used for the modulation of immune responses. Effective therapy using unmodified monoclonal antibodies has, however, been elusive. Recently, monoclonal antibody-mediated therapy has been revolutionized by advances such as the definition of cell-surface structures on abnormal cells as targets for effective monoclonal antibody action, genetic engineering to create less immunogenic and more effective monoclonal antibodies, and the arming of such antibodies with toxins or radionuclides to enhance their effector function.


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