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Science 14 June 1991:
Vol. 252. no. 5012, pp. 1551 - 1553
DOI: 10.1126/science.2047862
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Articles

Science, Vol 252, Issue 5012, 1551-1553
Copyright © 1991 by American Association for the Advancement of Science

articles

Generation of torsional and vertical eye position signals by the interstitial nucleus of Cajal

JD Crawford, W Cadera, and T Vilis

Department of Physiology, University of Western Ontario, London, Canada.

The neural integrator, which converts eye velocity signals into position signals, is central to oculomotor theory. Similar integrators are probably necessary in any neural system that changes and maintains muscular tension. The integrator for horizontal eye position is in the pons, but the locations of the vertical and torsional integrators have not been clearly defined. Recording three-dimensional eye movements in alert monkeys during microstimulation and pharmacological inactivation of midbrain sites showed that the interstitial nucleus of Cajal generates both the torsional and vertical eye position signals. Up and down signals are linked with clockwise signals in the right brain and counterclockwise signals in the left brain. This three-dimensional coordinate system achieves orthogonality and bilateral symmetry without redundancy and optimizes energy efficiency for horizontal visual scanning.


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