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Science 14 June 1991:
Vol. 252. no. 5012, pp. 1548 - 1550
DOI: 10.1126/science.1710827
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Articles

Science, Vol 252, Issue 5012, 1548-1550
Copyright © 1991 by American Association for the Advancement of Science

articles

Recognition by class II alloreactive T cells of processed determinants from human serum proteins

P Panina-Bordignon, G Corradin, E Roosnek, A Sette, and A Lanzavecchia

Basel Institute for Immunology, Switzerland.

Alloreactive T cells recognize a complex composed of an allogeneic major histocompatibility complex (MHC) molecule and a peptide derived from the processing of nonpolymorphic proteins. A sizable fraction of MHC class II alloreactive T cells is shown to recognize peptides derived from constitutive processing of human serum proteins. One such epitope is a fragment of human serum albumin. This epitope bound selectively to the human class II molecule DRw11 and was constitutively present on antigen-presenting cells in vivo. These data indicate that, in the case of MHC class II, peptides involved in allorecognition may originate from exogenous proteins.


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