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Science 7 June 1991:
Vol. 252. no. 5011, pp. 1430 - 1432
DOI: 10.1126/science.1828619
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Articles

Science, Vol 252, Issue 5011, 1430-1432
Copyright © 1991 by American Association for the Advancement of Science

articles

Recognition of self antigens by skin-derived T cells with invariant gamma delta antigen receptors

WL Havran, YH Chien, and JP Allison

Department of Molecular and Cell Biology, University of California, Berkeley 94720.

Thy-1+ dendritic epidermal T cells (dECs) express invariant gamma delta antigen receptors and are found in intimate contact with keratinocytes in murine epidermis--thus raising the possibility that keratinocytes express a ligand for the antigen receptor of these T cells. Thy-1+ dECs were stimulated to produce lymphokines by interaction with keratinocytes in vitro. This stimulation was mediated through the dEC antigen receptor and did not appear to be restricted by the major histocompatibility complex. Thus, dECs can recognize self antigens and may participate in immune surveillance for cellular damage rather than for foreign antigens.


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