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Science 17 May 1991:
Vol. 252. no. 5008, pp. 951 - 954
DOI: 10.1126/science.1852075
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Articles

Science, Vol 252, Issue 5008, 951-954
Copyright © 1991 by American Association for the Advancement of Science

articles

A calcium-dependent protein kinase with a regulatory domain similar to calmodulin

JF Harper, MR Sussman, GE Schaller, C Putnam-Evans, H Charbonneau, and AC Harmon

Department of Botany, Louisiana State University, Baton Rouge 70803.

Calcium can function as a second messenger through stimulation of calcium-dependent protein kinases. A protein kinase that requires calcium but not calmodulin or phospholipids for activity has been purified from soybean. The kinase itself binds calcium with high affinity. A complementary DNA clone for this kinase has been identified; it encodes a protein with a predicted molecular mass of 57,175 daltons. This protein contains a catalytic domain similar to that of calmodulin-dependent kinases and a calmodulin-like region with four calcium binding domains (EF hands). The predicted structure of this kinase explains its direct regulation via calcium binding and establishes it as a prototype for a new family of calcium-regulated protein kinases.


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