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Science 3 May 1991:
Vol. 252. no. 5006, pp. 704 - 706
DOI: 10.1126/science.1673802
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Articles

Science, Vol 252, Issue 5006, 704-706
Copyright © 1991 by American Association for the Advancement of Science

articles

Linkage of a cardiac arrhythmia, the long QT syndrome, and the Harvey ras-1 gene

M Keating, D Atkinson, C Dunn, K Timothy, GM Vincent, and M Leppert

Department of Human Genetics, University of Utah Health Sciences Center, Salt Lake City 84132.

Genetic factors contribute to heart disease. In this study, linkage analyses have been performed in a family that is predisposed to sudden death from cardiac arrhythmias, the long QT syndrome (LQT). A DNA marker at the Harvey ras-1 locus (H-ras-1) was linked to LQT with a logarithm of the likelihood ratio for linkage (lod score) of 16.44 at theta = 0, which confirms the genetic basis of this trait and localizes this gene to the short arm of chromosome 11. As no recombination was observed between LQT and H-ras-1, and there is a physiological rationale for its involvement in this disease, ras becomes a candidate for the disease locus.


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