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Science 26 April 1991:
Vol. 252. no. 5005, pp. 579 - 582
DOI: 10.1126/science.2020855
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Articles

Science, Vol 252, Issue 5005, 579-582
Copyright © 1991 by American Association for the Advancement of Science

articles

Spatial control of gut-specific gene expression during Caenorhabditis elegans development

EJ Aamodt, MA Chung, and JD McGhee

Department of Medical Biochemistry, University of Calgary, Alberta, Canada.

The nematode Caenorhabditis elegans was transformed with constructs containing upstream deletions of the gut-specific ges-1 carboxylesterase gene. With particular deletions, ges-1 was expressed, not as normally in the gut, but rather in muscle cells of the pharynx (which belong to a sister lineage of the gut) or in body wall muscle and hypodermal cells (which belong to a cousin lineage of the gut). These observations suggest that gut-specific gene expression in C. elegans involves not only gut-specific activators but also multiple repressors that are present in particular nongut lineages.


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