Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Science 19 April 1991:
Vol. 252. no. 5004, pp. 427 - 431
DOI: 10.1126/science.1826797
Prev | Table of Contents | Next

Articles

Science, Vol 252, Issue 5004, 427-431
Copyright © 1991 by American Association for the Advancement of Science

articles

Engraftment and development of human T and B cells in mice after bone marrow transplantation

I Lubin, Y Faktorowich, T Lapidot, Y Gan, Z Eshhar, E Gazit, M Levite, and Y Reisner

Department of Biophysics, Weizmann Institute of Science, Rehovot, Israel.

A model for human lymphocyte ontogeny has been developed in a normal mouse. Human bone marrow, depleted of mature T and B lymphocytes, and bone marrow from mice with severe combined immunodeficiency were transplanted into lethally irradiated BALB/c mice. Human B and T cells were first detected 2 to 4 months after transplantation and persisted for at least 6 months. Most human thymocytes (30 to 50 percent of total thymocytes) were CD3+CD4+CD8+. Human immunoglobulin was detected in some chimeras, and a human antibody response to dinitrophenol could be generated after primary and secondary immunization.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Long-Term Memory Is Facilitated by cAMP Response Element-Binding Protein Overexpression in the Amygdala.
S. A. Josselyn, C. Shi, W. A. Carlezon Jr, R. L. Neve, E. J. Nestler, and M. Davis (2001)
J. Neurosci. 21, 2404-2412
   Abstract »    Full Text »    PDF »
Human Cord Blood Progenitors Sustain Thymic T-Cell Development and a Novel Form of Angiogenesis.
L. Crisa, V. Cirulli, K. A. Smith, M. H. Ellisman, B. E. Torbett, and D. R. Salomon (1999)
Blood 94, 3928-3940
   Abstract »    Full Text »    PDF »
Direct Evidence for Biphasic cAMP Responsive Element-Binding Protein Phosphorylation during Long-Term Potentiation in the Rat Dentate Gyrus In Vivo.
S. Schulz, H. Siemer, M. Krug, and V. Hollt (1999)
J. Neurosci. 19, 5683-5692
   Abstract »    Full Text »    PDF »
Antigen-Specific IgG Responses from Naive Human Splenocytes: In Vitro Priming Followed by Antigen Boost in the SCID Mouse.
P. Brams, M.-L. Nguyen, S. Chamat, I. Royston, and P. R. Morrow (1998)
J. Immunol. 160, 2051-2058
   Abstract »    Full Text »    PDF »
PERINATAL INDUCTION OF IMMUNOTOLERANCE TO CARDIAC AND PULMONARY ALLOGRAFTS.
D. D. Yuh, K. L. Gandy, B. A. Reitz, G. Hoyt, and R. C. Robbins (1997)
J. Thorac. Cardiovasc. Surg. 114, 64-75
   Abstract »    Full Text »
Generation of a mouse strain that produces immunoglobulin kappa chains with human constant regions.
Y. Zou, H Gu, and K Rajewsky (1993)
Science 262, 1271-1274
   Abstract »    PDF »
Cytokine stimulation of multilineage hematopoiesis from immature human cells engrafted in SCID mice.
T Lapidot, F Pflumio, M Doedens, B Murdoch, D. Williams, and J. Dick (1992)
Science 255, 1137-1141
   Abstract »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)