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Science 22 March 1991:
Vol. 251. no. 5000, pp. 1485 - 1487
DOI: 10.1126/science.1900954
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Articles

Science, Vol 251, Issue 5000, 1485-1487
Copyright © 1991 by American Association for the Advancement of Science

articles

Cross-regulatory interactions between the proneural achaete and scute genes of Drosophila

C Martinez and J Modolell

Centro de Biologia Molecular, Consejo Superior de Investigaciones Cientificas, Universidad Autonoma de Madrid, Spain.

The achaete (ac) and scute (sc) genes of Drosophila allow cells to become sensory organ mother cells. Although ac and sc have similar patterns of expression, deletion of either gene removes specific subsets of sensory organs. This specificity was shown to reside in the peculiar regulation of ac and sc expression. These genes are first activated in complementary spatial domains in response to different cis-regulatory sequences. Each gene product then stimulates expression of the other gene, thus generating similar patterns of expression. Therefore, removal of one gene leads to the absence of both proneural gene products and sensory organs in the sites specified by its cis-regulatory sequences.


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