Related Content
Search Google Scholar for:
|
|
Science 22 March 1991: Vol. 251. no. 5000, pp. 1468 - 1470 DOI: 10.1126/science.251.5000.1468
|
|
Articles
Breaking the Diffraction Barrier: Optical Microscopy on a Nanometric Scale
E. BETZIG 1,
J. K. TRAUTMAN 1,
T. D. HARRIS 1,
J. S. WEINER 1, and
R. L. KOSTELAK 1
1 AT&T Bell Laboratories, 600 Mountain Avenue, Murray Hill, NJ 07974
In near-field scanning optical microscopy, a light source or detector with dimensions less than the wavelength ( ) is placed in close proximity ( /50) to a sample to generate images with resolution better than the diffraction limit. A near-field probe has been developed that yields a resolution of 12 nm ( /43) and signals 104- to 106-fold larger than those reported previously. In addition, image contrast is demonstrated to be highly polarization dependent. With these probes, near-field microscopy appears poised to fulfill its promise by combining the power of optical characterization methods with nanometric spatial resolution.
Submitted on November 30, 1990
Accepted on February 5, 1991
THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
- Breaking the diffraction barrier outside of the optical near-field with bright, collimated light from nanometric apertures.
- P. R. H. Stark, A. E. Halleck, and D. N. Larson (2007)
PNAS
104, 18902-18906
| Abstract »
| Full Text »
| PDF »
- High-Resolution Near-Field Optical Imaging of Single Nuclear Pore Complexes under Physiological Conditions.
- C. Hoppener, J. P. Siebrasse, R. Peters, U. Kubitscheck, and A. Naber (2005)
Biophys. J.
88, 3681-3688
| Abstract »
| Full Text »
| PDF »
- Tracking Femtosecond Laser Pulses in Space and Time.
- M. L. M. Balistreri, H. Gersen, J. P. Korterik, L. Kuipers, and N. F. van Hulst (2001)
Science
294, 1080-1082
| Abstract »
| Full Text »
| PDF »
- Altering the biochemical state of individual cultured cells and organelles with ultramicroelectrodes.
- J. A. Lundqvist, F. Sahlin, M. A. I. Aberg, A. Stromberg, P. S. Eriksson, and O. Orwar (1998)
PNAS
95, 10356-10360
| Abstract »
| Full Text »
| PDF »
- Micrometer- and Nanometer-Sized Polymeric Light-Emitting Diodes.
- M. Granstrom, M. Berggren, and O. Inganas (1995)
Science
267, 1479-1481
| Abstract »
| PDF »
- Probing individual molecules with confocal fluorescence microscopy.
- S Nie, D. Chiu, and R. Zare (1994)
Science
266, 1018-1021
| Abstract »
| PDF »
- Probing Single Molecule Dynamics.
- X. S. Xie and R. C. Dunn (1994)
Science
265, 361-364
| Abstract »
| PDF »
- Alterations of Single Molecule Fluorescence Lifetimes in Near-Field Optical Microscopy.
- W. P. Ambrose, P. M. Goodwin, R. A. Keller, and J. C. Martin (1994)
Science
265, 364-367
| Abstract »
| PDF »
- Near-Field Spectroscopy of the Quantum Constituents of a Luminescent System.
- H. F. Hess, E. Betzig, T. D. Harris, L. N. Pfeiffer, and K. W. West (1994)
Science
264, 1740-1745
| Abstract »
| PDF »
- Near-Field Optics: Imaging Single Molecules.
- R. Kopelman and W. Tan (1993)
Science
262, 1382-1384
| PDF »
- Single Molecules Observed by Near-Field Scanning Optical Microscopy.
- E. Betzig and R. J. Chichester (1993)
Science
262, 1422-1425
| Abstract »
| PDF »
- Submicrometer intracellular chemical optical fiber sensors.
- W Tan, Z. Shi, S Smith, D Birnbaum, and R Kopelman (1992)
Science
258, 778-781
| Abstract »
| PDF »
- Near-Field Optics: Microscopy, Spectroscopy, and Surface Modification Beyond the Diffraction Limit.
- E. Betzig and J. K. Trautman (1992)
Science
257, 189-195
| Abstract »
| PDF »
|
|