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Science 22 March 1991: Vol. 251. no. 5000, pp. 1451 - 1455 DOI: 10.1126/science.2006419
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Articles
Science, Vol 251, Issue 5000, 1451-1455
Copyright © 1991 by American Association for the Advancement of Science
Cadherin cell adhesion receptors as a morphogenetic regulator
M Takeichi
Department of Biophysics, Faculty of Science, Kyoto University, Japan.
Cadherins are a family of cell adhesion receptors that are crucial for the mutual association of vertebrate cells. Through their homophilic binding interactions, cadherins play a role in cell-sorting mechanisms, conferring adhesion specificities on cells. The regulated expression of cadherins also controls cell polarity and tissue morphology. Cadherins are thus considered to be important regulators of morphogenesis. Moreover, pathological examinations suggest that the down-regulation of cadherin expression is associated with the invasiveness of tumor cells.
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- Methylation of the {gamma}-Catenin Gene Is Associated With Poor Prognosis of Renal Cell Carcinoma.
- J. E. Breault, H. Shiina, M. Igawa, L. A. Ribeiro-Filho, M. Deguchi, H. Enokida, S. Urakami, M. Terashima, M. Nakagawa, C. J. Kane, et al. (2005)
Clin. Cancer Res.
11, 557-564
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- Modifier of Cell Adhesion Regulates N-Cadherin-Mediated Cell-Cell Adhesion and Neurite Outgrowth.
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J. Neurosci.
25, 281-290
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- Soluble P-Cadherin Found in Human Semen.
- A. L. De Paul, M. Bonaterra, A. P. Soler, K. A. Knudsen, F. D. Roth, and A. Aoki (2005)
J Androl
26, 44-47
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- A novel pathological role of p53 in kidney development revealed by gene-environment interactions.
- H. Fan, J. R. Harrell, S. Dipp, Z. Saifudeen, and S. S. El-Dahr (2005)
Am J Physiol Renal Physiol
288, F98-F107
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- Oncogenic Raf-1 regulates epithelial to mesenchymal transition via distinct signal transduction pathways in an immortalized mouse hepatic cell line.
- M. Lan, T. Kojima, M. Osanai, H. Chiba, and N. Sawada (2004)
Carcinogenesis
25, 2385-2395
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- Importance of Tumor Necrosis Factor-{alpha} Cleavage Process in Post-Transplantation Lung Injury in Rats.
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Am. J. Respir. Crit. Care Med.
170, 1239-1246
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- Trans-bonded pairs of E-cadherin exhibit a remarkable hierarchy of mechanical strengths.
- E. Perret, A. Leung, H. Feracci, and E. Evans (2004)
PNAS
101, 16472-16477
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- NDRG1 Is Necessary for p53-dependent Apoptosis.
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279, 48930-48940
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- Interaction with Protocadherin-{gamma} Regulates the Cell Surface Expression of Protocadherin-{alpha}.
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279, 49508-49516
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- A functional polymorphism (-347 G->GA) in the E-cadherin gene is associated with colorectal cancer.
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Carcinogenesis
25, 2173-2176
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- Involvement of Cell Surface HSP90 in Cell Migration Reveals a Novel Role in the Developing Nervous System.
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279, 45379-45388
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- Clinical and Biomarker Correlates of Androgen-Independent, Locally Aggressive Prostate Cancer with Limited Metastatic Potential.
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Clin. Cancer Res.
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- Prognostic value of E-cadherin immunoexpression in patients with primary ovarian carcinomas.
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Ann. Onc.
15, 1535-1542
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- Cell Adhesion, Polarity, and Epithelia in the Dawn of Metazoans.
- M. Cereijido, R. G. Contreras, and L. Shoshani (2004)
Physiol Rev
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- Proteolytic Shedding of the Extracellular Domain of Photoreceptor Cadherin: IMPLICATIONS FOR OUTER SEGMENT ASSEMBLY.
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- N-cadherin Activation Substitutes for the Cell Contact Control in Cell Cycle Arrest and Myogenic Differentiation: INVOLVEMENT OF p120 AND {beta}-CATENIN.
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279, 36795-36802
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- Rap1 Regulates E-cadherin-mediated Cell-Cell Adhesion.
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- A Mouse Skin Multistage Carcinogenesis Model Reflects the Aberrant DNA Methylation Patterns of Human Tumors.
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Cancer Res.
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