Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Site Tools

  • AAAS
  • Subscribe
  • Feedback

Site Search

Search Advanced

Science 22 March 1991:
Vol. 251. no. 5000, pp. 1451 - 1455
DOI: 10.1126/science.2006419
Prev | Table of Contents | Next

Articles

Science, Vol 251, Issue 5000, 1451-1455
Copyright © 1991 by American Association for the Advancement of Science

articles

Cadherin cell adhesion receptors as a morphogenetic regulator

M Takeichi

Department of Biophysics, Faculty of Science, Kyoto University, Japan.

Cadherins are a family of cell adhesion receptors that are crucial for the mutual association of vertebrate cells. Through their homophilic binding interactions, cadherins play a role in cell-sorting mechanisms, conferring adhesion specificities on cells. The regulated expression of cadherins also controls cell polarity and tissue morphology. Cadherins are thus considered to be important regulators of morphogenesis. Moreover, pathological examinations suggest that the down-regulation of cadherin expression is associated with the invasiveness of tumor cells.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Slit-2 Induces a Tumor-suppressive Effect by Regulating {beta}-Catenin in Breast Cancer Cells.
A. Prasad, V. Paruchuri, A. Preet, F. Latif, and R. K. Ganju (2008)
J. Biol. Chem. 283, 26624-26633
   Abstract »    Full Text »    PDF »
Genetic Polymorphisms of the E-Cadherin Promoter and Risk of Sporadic Gastric Carcinoma in Chinese Populations.
B. Zhang, K. Pan, Z. Liu, J. Zhou, L. Gu, J. Ji, J. Ma, W.-c. You, and D. Deng (2008)
Cancer Epidemiol. Biomarkers Prev. 17, 2402-2408
   Abstract »    Full Text »    PDF »
Deciphering the function of canonical Wnt signals in development and disease: conditional loss- and gain-of-function mutations of {beta}-catenin in mice.
T. Grigoryan, P. Wend, A. Klaus, and W. Birchmeier (2008)
Genes & Dev. 22, 2308-2341
   Abstract »    Full Text »    PDF »
Novel role of nectin: implication in the co-localization of JAM-A and claudin-1 at the same cell-cell adhesion membrane domain..
K. Kuramitsu, W. Ikeda, N. Inoue, Y. Tamaru, and Y. Takai (2008)
Genes Cells 13, 797-805
   Abstract »    Full Text »    PDF »
Canonical Wnt Signaling Controls Proliferation of Retinal Stem/Progenitor Cells in Postembryonic Xenopus Eyes.
T. Denayer, M. Locker, C. Borday, T. Deroo, S. Janssens, A. Hecht, F. van Roy, M. Perron, and K. Vleminckx (2008)
Stem Cells 26, 2063-2074
   Abstract »    Full Text »    PDF »
The Allosteric Role of the Ca2+ Switch in Adhesion and Elasticity of C-Cadherin.
M. Sotomayor and K. Schulten (2008)
Biophys. J. 94, 4621-4633
   Abstract »    Full Text »    PDF »
Cell-Cell Adhesion in the Cnidaria: Insights Into the Evolution of Tissue Morphogenesis.
C. R. Magie and M. Q. Martindale (2008)
Biol. Bull. 214, 218-232
   Abstract »    Full Text »    PDF »
Establishment of cell-cell junctions depends on the oligomeric states of VE-cadherin.
S. Bibert, H. Ayari, D. Riveline, E. Concord, B. Hermant, T. Vernet, and D. Gulino-Debrac (2008)
J. Biochem. 143, 821-832
   Abstract »    Full Text »    PDF »
Regulation of Dedifferentiation and Redifferentiation in Renal Proximal Tubular Cells by the Epidermal Growth Factor Receptor.
M. A. Hallman, S. Zhuang, and R. G. Schnellmann (2008)
J. Pharmacol. Exp. Ther. 325, 520-528
   Abstract »    Full Text »    PDF »
E-cadherin expression in canine cutaneous histiocytomas.
S. J. Baines, E. F. McInnes, and I. McConnell (2008)
Vet Rec. 162, 509-513
   Abstract »    Full Text »    PDF »
Dual function of Src in the maintenance of adherens junctions during tracheal epithelial morphogenesis.
M. Shindo, H. Wada, M. Kaido, M. Tateno, T. Aigaki, L. Tsuda, and S. Hayashi (2008)
Development 135, 1355-1364
   Abstract »    Full Text »    PDF »
Cdc42 Regulates E-cadherin Ubiquitination and Degradation through an Epidermal Growth Factor Receptor to Src-mediated Pathway.
Y. Shen, D. S. Hirsch, C. A. Sasiela, and W. J. Wu (2008)
J. Biol. Chem. 283, 5127-5137
   Abstract »    Full Text »    PDF »
Immediate-Early Signaling Induced by E-cadherin Engagement and Adhesion.
T. D. Perez, M. Tamada, M. P. Sheetz, and W. J. Nelson (2008)
J. Biol. Chem. 283, 5014-5022
   Abstract »    Full Text »    PDF »
Reduced hGC-1 Protein Expression Is Associated with Malignant Progression of Colon Carcinoma.
W. Liu, Y. Liu, J. Zhu, E. Wright, I. Ding, and G. P. Rodgers (2008)
Clin. Cancer Res. 14, 1041-1049
   Abstract »    Full Text »    PDF »
Molecular Pathogenesis of Oral Squamous Cell Carcinoma: Implications for Therapy.
S. Choi and J.N. Myers (2008)
J. Dent. Res. 87, 14-32
   Abstract »    Full Text »    PDF »
NDRG1, a growth and cancer related gene: regulation of gene expression and function in normal and disease states.
T. P. Ellen, Q. Ke, P. Zhang, and M. Costa (2008)
Carcinogenesis 29, 2-8
   Abstract »    Full Text »    PDF »
Collagen I Promotes Epithelial-to-Mesenchymal Transition in Lung Cancer Cells via Transforming Growth Factor Signaling.
Y. Shintani, M. Maeda, N. Chaika, K. R. Johnson, and M. J. Wheelock (2008)
Am. J. Respir. Cell Mol. Biol. 38, 95-104
   Abstract »    Full Text »    PDF »
Establishment of cell polarity by afadin during the formation of embryoid bodies..
H. Komura, H. Ogita, W. Ikeda, A. Mizoguchi, J. Miyoshi, and Y. Takai (2008)
Genes Cells 13, 79-90
   Abstract »    Full Text »    PDF »
Drug Sensitivity Prediction by CpG Island Methylation Profile in the NCI-60 Cancer Cell Line Panel.
L. Shen, Y. Kondo, S. Ahmed, Y. Boumber, K. Konishi, Y. Guo, X. Chen, J. N. Vilaythong, and J.-P. J. Issa (2007)
Cancer Res. 67, 11335-11343
   Abstract »    Full Text »    PDF »
Alterations of DNA methylation associated with abnormalities of DNA methyltransferases in human cancers during transition from a precancerous to a malignant state.
Y. Kanai and S. Hirohashi (2007)
Carcinogenesis 28, 2434-2442
   Abstract »    Full Text »    PDF »
Altered E-Cadherin Expression and p120 Catenin Localization in Esophageal Squamous Cell Carcinoma.
Y. Chung, A. K. Y. Lam, J. M. Luk, S. Law, K.-W. Chan, P.-Y. Lee, and J. Wong (2007)
Ann. Surg. Oncol. 14, 3260-3267
   Abstract »    Full Text »    PDF »
Effects of reduced tidal volume ventilation on pulmonary function in mice before and after acute lung injury.
A. Thammanomai, A. Majumdar, E. Bartolak-Suki, and B. Suki (2007)
J Appl Physiol 103, 1551-1559
   Abstract »    Full Text »    PDF »
Up-regulation of Loricrin Expression by Cell Adhesion Molecule Nectin-1 through Rap1-ERK Signaling in Keratinocytes.
K. Wakamatsu, H. Ogita, N. Okabe, K. Irie, M. Tanaka-Okamoto, H. Ishizaki, A. Ishida-Yamamoto, H. Iizuka, J. Miyoshi, and Y. Takai (2007)
J. Biol. Chem. 282, 18173-18181
   Abstract »    Full Text »    PDF »
Male-specific sterility caused by the loss of CR16.
S. Suetsugu, Y. Banzai, M. Kato, K. Fukami, Y. Kataoka, Y. Takai, N. Yoshida, and T. Takenawa (2007)
Genes Cells 12, 721-733
   Abstract »    Full Text »    PDF »
Change of E-Cadherin by Hepatocyte Growth Factor and Effects on the Prognosis of Hypopharyngeal Carcinoma.
C.-H. Kim, J. Kim, H. Kahng, and E. C. Choi (2007)
Ann. Surg. Oncol. 14, 1565-1574
   Abstract »    Full Text »    PDF »
Tumor Cell-Organ Microenvironment Interactions in the Pathogenesis of Cancer Metastasis.
R. R. Langley and I. J. Fidler (2007)
Endocr. Rev. 28, 297-321
   Abstract »    Full Text »    PDF »
Involvement of integrin-induced activation of protein kinase C in the formation of adherens junctions.
M. Ozaki, H. Ogita, and Y. Takai (2007)
Genes Cells 12, 651-662
   Abstract »    Full Text »    PDF »
Evidences that Leptin Up-regulates E-Cadherin Expression in Breast Cancer: Effects on Tumor Growth and Progression.
L. Mauro, S. Catalano, G. Bossi, M. Pellegrino, I. Barone, S. Morales, C. Giordano, V. Bartella, I. Casaburi, and S. Ando (2007)
Cancer Res. 67, 3412-3421
   Abstract »    Full Text »    PDF »
Microtubule-induced cortical cell polarity.
S. E. Siegrist and C. Q. Doe (2007)
Genes & Dev. 21, 483-496
   Abstract »    Full Text »    PDF »
N-Cadherin Is Expressed by Putative Stem/Progenitor Cells and Melanocytes in the Human Limbal Epithelial Stem Cell Niche.
R. Hayashi, M. Yamato, H. Sugiyama, T. Sumide, J. Yang, T. Okano, Y. Tano, and K. Nishida (2007)
Stem Cells 25, 289-296
   Abstract »    Full Text »    PDF »
Expression of Liver-Intestine Cadherin and Its Correlation with Lymph Node Metastasis in Gastric Cancer: Can It Predict N Stage Preoperatively?.
S.-S. Park, S.-H. Kang, J.-M. Park, J.-H. Kim, S.-C. Oh, J.-H. Lee, Y.-S. Chae, S.-J. Kim, C.-S. Kim, and Y.-J. Mok (2007)
Ann. Surg. Oncol. 14, 94-99
   Abstract »    Full Text »    PDF »
Depletion of E-Cadherin Disrupts Establishment but Not Maintenance of Cell Junctions in Madin-Darby Canine Kidney Epithelial Cells.
C. T. Capaldo and I. G. Macara (2007)
Mol. Biol. Cell 18, 189-200
   Abstract »    Full Text »    PDF »
Activation of DNA Methyltransferase 1 by EBV LMP1 Involves c-Jun NH2-Terminal Kinase Signaling.
C.-L. Tsai, H.-P. Li, Y.-J. Lu, C. Hsueh, Y. Liang, C.-L. Chen, S. W. Tsao, K.-P. Tse, J.-S. Yu, and Y.-S. Chang (2006)
Cancer Res. 66, 11668-11676
   Abstract »    Full Text »    PDF »
Expression of Claudin7 Is Tightly Associated with Epithelial Structures in Synovial Sarcomas and Regulated by an Ets Family Transcription Factor, ELF3.
Y. Kohno, T. Okamoto, T. Ishibe, S. Nagayama, Y. Shima, K. Nishijo, K. R. Shibata, K. Fukiage, S. Otsuka, D. Uejima, et al. (2006)
J. Biol. Chem. 281, 38941-38950
   Abstract »    Full Text »    PDF »
Normal Establishment of Epithelial Tight Junctions in Mice and Cultured Cells Lacking Expression of ZO-3, a Tight-Junction MAGUK Protein.
M. Adachi, A. Inoko, M. Hata, K. Furuse, K. Umeda, M. Itoh, and S. Tsukita (2006)
Mol. Cell. Biol. 26, 9003-9015
   Abstract »    Full Text »    PDF »
Calreticulin Represses E-cadherin Gene Expression in Madin-Darby Canine Kidney Cells via Slug.
Y. Hayashida, Y. Urata, E. Muroi, T. Kono, Y. Miyata, K. Nomata, H. Kanetake, T. Kondo, and Y. Ihara (2006)
J. Biol. Chem. 281, 32469-32484
   Abstract »    Full Text »    PDF »
Similarities between heterophilic and homophilic cadherin adhesion.
A. K. Prakasam, V. Maruthamuthu, and D. E. Leckband (2006)
PNAS 103, 15434-15439
   Abstract »    Full Text »    PDF »
The Variable Transmembrane Domain of Drosophila N-Cadherin Regulates Adhesive Activity..
S. Yonekura, C.-Y. Ting, G. Neves, K. Hung, S.-n. Hsu, A. Chiba, A. Chess, and C.-H. Lee (2006)
Mol. Cell. Biol. 26, 6598-6608
   Abstract »    Full Text »    PDF »
Epigenetic Silencing of the Tumor Suppressor Cystatin M Occurs during Breast Cancer Progression.
L. Ai, W.-J. Kim, T.-Y. Kim, C. R. Fields, N. A. Massoll, K. D. Robertson, and K. D. Brown (2006)
Cancer Res. 66, 7899-7909
   Abstract »    Full Text »    PDF »
Regulation of epithelial wound closure and intercellular adhesion by interaction of AF6 with actin cytoskeleton.
M. Lorger and K. Moelling (2006)
J. Cell Sci. 119, 3385-3398
   Abstract »    Full Text »    PDF »
Cell and fibronectin dynamics during branching morphogenesis.
M. Larsen, C. Wei, and K. M. Yamada (2006)
J. Cell Sci. 119, 3376-3384
   Abstract »    Full Text »    PDF »
GEP100/BRAG2: Activator of ADP-ribosylation factor 6 for regulation of cell adhesion and actin cytoskeleton via E-cadherin and {alpha}-catenin.
T. Hiroi, A. Someya, W. Thompson, J. Moss, and M. Vaughan (2006)
PNAS 103, 10672-10677
   Abstract »    Full Text »    PDF »
{beta}-Catenin and E-Cadherin Expression in Salivary Gland Tumors..
C. Furuse, P. R. Cury, A. Altemani, D. dos Santos Pinto Junior, N. S. de Araujo, and V. C. de Araujo (2006)
International Journal of Surgical Pathology 14, 212-217
   Abstract »    PDF »
Epithelial-Mesenchymal Transition in Lung Cancer: Is Tobacco the "Smoking Gun"?.
V. Dasari, M. Gallup, H. Lemjabbar, I. Maltseva, and N. McNamara (2006)
Am. J. Respir. Cell Mol. Biol. 35, 3-9
   Full Text »    PDF »
Inhibition of E-Cadherin-Mediated Homotypic Adhesion of Caco-2 Cells: A Novel Evaluation Assay for Peptide Activities in Modulating Cell-Cell Adhesion.
N. Kobayashi, A. Ikesue, S. Majumdar, and T. J. Siahaan (2006)
J. Pharmacol. Exp. Ther. 317, 309-316
   Abstract »    Full Text »    PDF »
Gene Promoter Hypermethylation in Mouse Lung Tumors.
B. R. Vuillemenot, J. A. Hutt, and S. A. Belinsky (2006)
Mol. Cancer Res. 4, 267-273
   Abstract »    Full Text »    PDF »
Ena/VASP Proteins Can Regulate Distinct Modes of Actin Organization at Cadherin-adhesive Contacts.
J. A. Scott, A. M. Shewan, N. R. den Elzen, J. J. Loureiro, F. B. Gertler, and A. S. Yap (2006)
Mol. Biol. Cell 17, 1085-1095
   Abstract »    Full Text »    PDF »
Killer cell lectin-like receptor G1 binds three members of the classical cadherin family to inhibit NK cell cytotoxicity.
M. Ito, T. Maruyama, N. Saito, S. Koganei, K. Yamamoto, and N. Matsumoto (2006)
J. Exp. Med. 203, 289-295
   Abstract »    Full Text »    PDF »
Lifetime Measurements Reveal Kinetic Differences between Homophilic Cadherin Bonds.
M. V. Bayas, A. Leung, E. Evans, and D. Leckband (2006)
Biophys. J. 90, 1385-1395
   Abstract »    Full Text »    PDF »
Development and Regulation of Dendritic Spine Synapses.
B. Calabrese, M. S. Wilson, and S. Halpain (2006)
Physiology 21, 38-47
   Abstract »    Full Text »    PDF »
Novel Three-Dimensional Organoid Model for Evaluation of the Interaction of Uropathogenic Escherichia coli with Terminally Differentiated Human Urothelial Cells.
Y. C. Smith, K. K. Grande, S. B. Rasmussen, and A. D. O'Brien (2006)
Infect. Immun. 74, 750-757
   Abstract »    Full Text »    PDF »
Genetics, Pathology, and Clinics of Familial Gastric Cancer.
C. Oliveira, R. Seruca, and F. Carneiro (2006)
International Journal of Surgical Pathology 14, 21-33
   Abstract »    PDF »
Single-molecule analysis of cadherin-mediated cell-cell adhesion.
P. Panorchan, M. S. Thompson, K. J. Davis, Y. Tseng, K. Konstantopoulos, and D. Wirtz (2006)
J. Cell Sci. 119, 66-74
   Abstract »    Full Text »    PDF »
SIP1/ZEB2 induces EMT by repressing genes of different epithelial cell-cell junctions.
C. Vandewalle, J. Comijn, B. De Craene, P. Vermassen, E. Bruyneel, H. Andersen, E. Tulchinsky, F. Van Roy, and G. Berx (2005)
Nucleic Acids Res. 33, 6566-6578
   Abstract »    Full Text »    PDF »
E-Cadherin and {beta}-catenin Reduction Influence Invasion but not Proliferation and Survival in Canine Malignant Mammary Tumors.
B. Brunetti, G. Sarli, R. Preziosi, I. Monari, and C. Benazzi (2005)
Vet. Pathol. 42, 781-787
   Abstract »    Full Text »    PDF »
Dietary Components Modify Gene Expression: Implications for Carcinogenesis.
K. Yang, W. Yang, J. Mariadason, A. Velcich, M. Lipkin, and L. Augenlicht (2005)
J. Nutr. 135, 2710-2714
   Abstract »    Full Text »    PDF »
TGF{beta}-induced downregulation of E-cadherin-based cell-cell adhesion depends on PI3-kinase and PTEN.
R. Vogelmann, M.-D. Nguyen-tat, K. Giehl, G. Adler, D. Wedlich, and A. Menke (2005)
J. Cell Sci. 118, 4901-4912
   Abstract »    Full Text »    PDF »
Formation of E-Cadherin-Mediated Cell-Cell Adhesion Activates Akt and Mitogen Activated Protein Kinase via Phosphatidylinositol 3 Kinase and Ligand-Independent Activation of Epidermal Growth Factor Receptor in Ovarian Cancer Cells.
P. Reddy, L. Liu, C. Ren, P. Lindgren, K. Boman, Y. Shen, E. Lundin, U. Ottander, M. Rytinki, and K. Liu (2005)
Mol. Endocrinol. 19, 2564-2578
   Abstract »    Full Text »    PDF »
Myosin 2 Is a Key Rho Kinase Target Necessary for the Local Concentration of E-Cadherin at Cell-Cell Contacts.
A. M. Shewan, M. Maddugoda, A. Kraemer, S. J. Stehbens, S. Verma, E. M. Kovacs, and A. S. Yap (2005)
Mol. Biol. Cell 16, 4531-4542
   Abstract »    Full Text »    PDF »
Cell adhesion molecules regulate Ca2+-mediated steering of growth cones via cyclic AMP and ryanodine receptor type 3.
N. Ooashi, A. Futatsugi, F. Yoshihara, K. Mikoshiba, and H. Kamiguchi (2005)
J. Cell Biol. 170, 1159-1167
   Abstract »    Full Text »    PDF »
P-Cadherin Overexpression Is an Indicator of Clinical Outcome in Invasive Breast Carcinomas and Is Associated with CDH3 Promoter Hypomethylation.
J. Paredes, A. Albergaria, J. T. Oliveira, C. Jeronimo, F. Milanezi, and F. C. Schmitt (2005)
Clin. Cancer Res. 11, 5869-5877
   Abstract »    Full Text »    PDF »
Structural and Functional Analyses of a Novel Ig-like Cell Adhesion Molecule, hepaCAM, in the Human Breast Carcinoma MCF7 Cells.
M. C. Moh, C. Zhang, C. Luo, L. H. Lee, and S. Shen (2005)
J. Biol. Chem. 280, 27366-27374
   Abstract »    Full Text »    PDF »
Critical Role of the Fifth Domain of E-Cadherin for Heterophilic Adhesion with {alpha}E{beta}7, But Not for Homophilic Adhesion.
K. Shiraishi, K. Tsuzaka, K. Yoshimoto, C. Kumazawa, K. Nozaki, T. Abe, K. Tsubota, and T. Takeuchi (2005)
J. Immunol. 175, 1014-1021
   Abstract »    Full Text »    PDF »
Prognostic significance of syndecan-1 expression in human endometrial cancer.
Hasengaowa, J. Kodama, T. Kusumoto, Y. Shinyo, N. Seki, and Y. Hiramatsu (2005)
Ann. Onc. 16, 1109-1115
   Abstract »    Full Text »    PDF »
ADAM10 mediates E-cadherin shedding and regulates epithelial cell-cell adhesion, migration, and {beta}-catenin translocation.
T. Maretzky, K. Reiss, A. Ludwig, J. Buchholz, F. Scholz, E. Proksch, B. de Strooper, D. Hartmann, and P. Saftig (2005)
PNAS 102, 9182-9187
   Abstract »    Full Text »    PDF »
Regulation of E-cadherin Endocytosis by Nectin through Afadin, Rap1, and p120ctn.
T. Hoshino, T. Sakisaka, T. Baba, T. Yamada, T. Kimura, and Y. Takai (2005)
J. Biol. Chem. 280, 24095-24103
   Abstract »    Full Text »    PDF »
Placental Cadherin and the Basal Epithelial Phenotype of BRCA1-Related Breast Cancer.
J. B. Arnes, J.-S. Brunet, I. Stefansson, L. R. Begin, N. Wong, P. O. Chappuis, L. A. Akslen, and W. D. Foulkes (2005)
Clin. Cancer Res. 11, 4003-4011
   Abstract »    Full Text »    PDF »
Platelet-Activating Factor Regulates Cadherin-Catenin Adhesion System Expression and {beta}-Catenin Phosphorylation during Kaposi's Sarcoma Cell Motility.
M. Boccellino, G. Camussi, A. Giovane, L. Ferro, V. Calderaro, C. Balestrieri, and L. Quagliuolo (2005)
Am. J. Pathol. 166, 1515-1522
   Abstract »    Full Text »    PDF »
A Three-Dimensional Cellular Model of the Human Respiratory Tract to Study the Interaction with Particles.
B. M. Rothen-Rutishauser, S. G. Kiama, and P. Gehr (2005)
Am. J. Respir. Cell Mol. Biol. 32, 281-289
   Abstract »    Full Text »    PDF »
Rab11 in Recycling Endosomes Regulates the Sorting and Basolateral Transport of E-Cadherin.
J. G. Lock and J. L. Stow (2005)
Mol. Biol. Cell 16, 1744-1755
   Abstract »    Full Text »    PDF »
Association of a Genetic Polymorphism of the E-cadherin Gene with Prostate Cancer in a Japanese Population.
T. Kamoto, Y. Isogawa, Y. Shimizu, S. Minamiguchi, H. Kinoshita, Y. Kakehi, K. Mitsumori, S. Yamamoto, T. Habuchi, T. Kato, et al. (2005)
Jpn. J. Clin. Oncol. 35, 158-161
   Abstract »    Full Text »    PDF »
Separation Force Measurements Reveal Different Types of Modulation of E-cadherin-based Adhesion by Nectin-1 and -3.
C. Martinez-Rico, F. Pincet, E. Perez, J. P. Thiery, K. Shimizu, Y. Takai, and S. Dufour (2005)
J. Biol. Chem. 280, 4753-4760
   Abstract »    Full Text »    PDF »
Vav2 as a Rac-GDP/GTP Exchange Factor Responsible for the Nectin-induced, c-Src- and Cdc42-mediated Activation of Rac.
T. Kawakatsu, H. Ogita, T. Fukuhara, T. Fukuyama, Y. Minami, K. Shimizu, and Y. Takai (2005)
J. Biol. Chem. 280, 4940-4947
   Abstract »    Full Text »    PDF »
A549 Lung Epithelial Cells Grown as Three-Dimensional Aggregates: Alternative Tissue Culture Model for Pseudomonas aeruginosa Pathogenesis.
A. J. Carterson, K. Honer zu Bentrup, C. M. Ott, M. S. Clarke, D. L. Pierson, C. R. Vanderburg, K. L. Buchanan, C. A. Nickerson, and M. J. Schurr (2005)
Infect. Immun. 73, 1129-1140
   Abstract »    Full Text »    PDF »
E-Cadherin Phosphorylation by Protein Kinase D1/Protein Kinase C{micro} is Associated with Altered Cellular Aggregation and Motility in Prostate Cancer.
M. Jaggi, P. S. Rao, D. J. Smith, M. J. Wheelock, K. R. Johnson, G. P. Hemstreet, and K.C. Balaji (2005)
Cancer Res. 65, 483-492
   Abstract »    Full Text »    PDF »
Calcium Sensing Receptor in Human Colon Carcinoma: Interaction with Ca2+ and 1,25-Dihydroxyvitamin D3.
S. Chakrabarty, H. Wang, L. Canaff, G. N. Hendy, H. Appelman, and J. Varani (2005)
Cancer Res. 65, 493-498
   Abstract »    Full Text »    PDF »
Methylation of the {gamma}-Catenin Gene Is Associated With Poor Prognosis of Renal Cell Carcinoma.
J. E. Breault, H. Shiina, M. Igawa, L. A. Ribeiro-Filho, M. Deguchi, H. Enokida, S. Urakami, M. Terashima, M. Nakagawa, C. J. Kane, et al. (2005)
Clin. Cancer Res. 11, 557-564
   Abstract »    Full Text »    PDF »
Modifier of Cell Adhesion Regulates N-Cadherin-Mediated Cell-Cell Adhesion and Neurite Outgrowth.
Q. Chen, T.-J. Chen, P. C. Letourneau, L. Da F. Costa, and D. Schubert (2005)
J. Neurosci. 25, 281-290
   Abstract »    Full Text »    PDF »
Soluble P-Cadherin Found in Human Semen.
A. L. De Paul, M. Bonaterra, A. P. Soler, K. A. Knudsen, F. D. Roth, and A. Aoki (2005)
J Androl 26, 44-47
   Abstract »    Full Text »    PDF »
A novel pathological role of p53 in kidney development revealed by gene-environment interactions.
H. Fan, J. R. Harrell, S. Dipp, Z. Saifudeen, and S. S. El-Dahr (2005)
Am J Physiol Renal Physiol 288, F98-F107
   Abstract »    Full Text »    PDF »
Oncogenic Raf-1 regulates epithelial to mesenchymal transition via distinct signal transduction pathways in an immortalized mouse hepatic cell line.
M. Lan, T. Kojima, M. Osanai, H. Chiba, and N. Sawada (2004)
Carcinogenesis 25, 2385-2395
   Abstract »    Full Text »    PDF »
Importance of Tumor Necrosis Factor-{alpha} Cleavage Process in Post-Transplantation Lung Injury in Rats.
T. Goto, A. Ishizaka, F. Kobayashi, M. Kohno, M. Sawafuji, S. Tasaka, E. Ikeda, Y. Okada, I. Maruyama, and K. Kobayashi (2004)
Am. J. Respir. Crit. Care Med. 170, 1239-1246
   Abstract »    Full Text »    PDF »
Trans-bonded pairs of E-cadherin exhibit a remarkable hierarchy of mechanical strengths.
E. Perret, A. Leung, H. Feracci, and E. Evans (2004)
PNAS 101, 16472-16477
   Abstract »    Full Text »    PDF »
NDRG1 Is Necessary for p53-dependent Apoptosis.
S. Stein, E. K. Thomas, B. Herzog, M. D. Westfall, J. V. Rocheleau, R. S. Jackson II, M. Wang, and P. Liang (2004)
J. Biol. Chem. 279, 48930-48940
   Abstract »    Full Text »    PDF »
Interaction with Protocadherin-{gamma} Regulates the Cell Surface Expression of Protocadherin-{alpha}.
Y. Murata, S. Hamada, H. Morishita, T. Mutoh, and T. Yagi (2004)
J. Biol. Chem. 279, 49508-49516
   Abstract »    Full Text »    PDF »
A functional polymorphism (-347 G->GA) in the E-cadherin gene is associated with colorectal cancer.
Y. Shin, I.-J. Kim, H. C. Kang, J.-H. Park, H.-W. Park, S.-G. Jang, M. R. Lee, S.-Y. Jeong, H. J. Chang, J.-L. Ku, et al. (2004)
Carcinogenesis 25, 2173-2176
   Abstract »    Full Text »    PDF »
Involvement of Cell Surface HSP90 in Cell Migration Reveals a Novel Role in the Developing Nervous System.
K. Sidera, M. Samiotaki, E. Yfanti, G. Panayotou, and E. Patsavoudi (2004)
J. Biol. Chem. 279, 45379-45388
   Abstract »    Full Text »    PDF »
Clinical and Biomarker Correlates of Androgen-Independent, Locally Aggressive Prostate Cancer with Limited Metastatic Potential.
V. J. Assikis, K.-A. Do, S. Wen, X. Wang, J. H. Cho-Vega, S. Brisbay, R. Lopez, C. J. Logothetis, P. Troncoso, C. N. Papandreou, et al. (2004)
Clin. Cancer Res. 10, 6770-6778
   Abstract »    Full Text »    PDF »
Prognostic value of E-cadherin immunoexpression in patients with primary ovarian carcinomas.
C. Faleiro-Rodrigues, I. Macedo-Pinto, D. Pereira, and C. S. Lopes (2004)
Ann. Onc. 15, 1535-1542
   Abstract »    Full Text »    PDF »
Cell Adhesion, Polarity, and Epithelia in the Dawn of Metazoans.
M. Cereijido, R. G. Contreras, and L. Shoshani (2004)
Physiol Rev 84, 1229-1262