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Science 1 March 1991:
Vol. 251. no. 4997, pp. 1076 - 1078
DOI: 10.1126/science.1825521
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Articles

Science, Vol 251, Issue 4997, 1076-1078
Copyright © 1991 by American Association for the Advancement of Science

articles

A model for the adjustment of the mitotic clock by cyclin and MPF levels

R Norel and Z Agur

Department of Applied Mathematics and Computer Science, Weizmann Institute of Science, Israel.

A mathematical model of cell cycle progression is presented, which integrates recent biochemical information on the interaction of the maturation promotion factor (MPF) and cyclin. The model retrieves the dynamics observed in early embryos and explains how multiple cycles of MPF activity can be produced and how the internal clock that determines durations and number of cycles can be adjusted by modulating the rate of change in MPF or cyclin concentrations. Experiments are suggested for verifying the role of MPF activity in determining the length of the somatic cell cycle.


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