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Science 22 February 1991:
Vol. 251. no. 4996, pp. 947 - 950
DOI: 10.1126/science.1825731
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Articles

Science, Vol 251, Issue 4996, 947-950
Copyright © 1991 by American Association for the Advancement of Science

articles

D1 dopamine receptors in prefrontal cortex: involvement in working memory

T Sawaguchi and PS Goldman-Rakic

Section of Neurobiology, Yale University School of Medicine, New Haven, CT 06510.

The prefrontal cortex is involved in the cognitive process of working memory. Local injections of SCH23390 and SCH39166, selective antagonists of the D1 dopamine receptor, into the prefrontal cortex of rhesus monkeys induced errors and increased latency in performance on an oculomotor task that required memory-guided saccades. The deficit was dose-dependent and sensitive to the duration of the delay period. These D1 antagonists had no effect on performance in a control task requiring visually guided saccades, indicating that sensory and motor functions were unaltered. Thus, D1 dopamine receptors play a selective role in the mnemonic, predictive functions of the primate prefrontal cortex.


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