Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Science 8 February 1991:
Vol. 251. no. 4994, pp. 640 - 642
DOI: 10.1126/science.1992517
Prev | Table of Contents | Next

Articles

Science, Vol 251, Issue 4994, 640-642
Copyright © 1991 by American Association for the Advancement of Science

articles

Graphite: a mimic for DNA and other biomolecules in scanning tunneling microscope studies

CR Clemmer and TP Beebe Jr

Department of Chemistry, University of Utah, Salt Lake City 84112.

Highly ordered pyrolytic graphite (HOPG) is the substrate often used in scanning tunneling microscope (STM) studies of biomolecules such as DNA. All of the images presented in this article are of freshly cleaved HOPG surfaces upon which no deposition has occurred. These images illustrate features previously thought to be due to biological molecules, such as periodicity and meandering of "molecules" over steps. These features can no longer be used to distinguish real molecules from features of the native substrate. The feasibility of the continued use of HOPG as a substrate for biological STM studies is discussed.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Vapor-Condensation Generation and STM Analysis of Fullerene Tubes.
M. Ge and K. Sattler (1993)
Science 260, 515-518
   Abstract »    PDF »
Reproducible Imaging and Dissection of Plasmid DNA Under Liquid with the Atomic Force Microscope.
H. G. Hansma, J. Vesenka, C. Siegerist, G. Kelderman, H. Morrett, R. L. Sinsheimer, V. Elings, C. Bustamante, and P. K. Hansma (1992)
Science 256, 1180-1184
   Abstract »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)