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Science 25 January 1991:
Vol. 251. no. 4992, pp. 430 - 432
DOI: 10.1126/science.1989076
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Articles

Science, Vol 251, Issue 4992, 430-432
Copyright © 1991 by American Association for the Advancement of Science

articles

T cell receptor peptide therapy triggers autoregulation of experimental encephalomyelitis

H Offner, GA Hashim, and AA Vandenbark

Neuroimmunology Research, Veterans Administration Medical Center, Portland, OR.

Encephalitogenic T cells specific for myelin basic protein share common V beta 8 peptide sequences in their T cell receptor (TCR) that can induce autoregulatory T cells and antibodies that prevent clinical signs of experimental autoimmune encephalomyelitis (EAE). It is not known, however, if TCR peptides can treat established disease. To test its therapeutic value, TCR-V beta 8-39-59 peptide was injected into rats with clinical signs of EAE. This treatment reduced disease severity and speeded recovery, apparently by boosting anti-V beta 8 T cells and antibodies raised naturally in response to encephalitogenic V beta 8+ T cells. These results demonstrate that synthetic TCR peptides can be used therapeutically, and implicate the TCR-V beta 8-39-59 sequence as a natural idiotope involved in EAE recovery. Similarly, human TCR peptides may be effective in enhancing natural regulation of autoreactive T cells that share common V genes.


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