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Science 21 December 1990:
Vol. 250. no. 4988, pp. 1720 - 1723
DOI: 10.1126/science.2125367
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Articles

Science, Vol 250, Issue 4988, 1720-1723
Copyright © 1990 by American Association for the Advancement of Science

articles

Induction by antigen of intrathymic apoptosis of CD4+CD8+TCRlo thymocytes in vivo

KM Murphy, AB Heimberger, and DY Loh

Department of Pathology, Washington University School of Medicine, St. Louis, MO 63110.

In order to examine the mechanisms by which clonal deletion of autoreactive T cells occurs, a peptide antigen was used to induce deletion of antigen-reactive thymocytes in vivo. Mice transgenic for a T cell receptor (TCR) that reacts to this peptide contain thymocytes that progress from the immature to the mature phenotype. Intraperitoneal administration of the peptide antigen to transgenic mice results in a rapid deletion of the immature CD4+ CD8+ TCRlo thymocytes. Apoptosis of cortical thymocytes can be seen within 20 hours of treatment. These results provide direct evidence for the in vivo role of apoptosis in the development of antigen-induced tolerance.


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T Cell, Ig Domain, Mucin Domain-2 Gene-Deficient Mice Reveal a Novel Mechanism for the Regulation of Th2 Immune Responses and Airway Inflammation.
P. D. Rennert, T. Ichimura, I. D. Sizing, V. Bailly, Z. Li, R. Rennard, P. McCoon, L. Pablo, S. Miklasz, L. Tarilonte, et al. (2006)
J. Immunol. 177, 4311-4321
   Abstract »    Full Text »    PDF »
CD25+CD4+ Regulatory T Cells and Memory T Cells Prevent Lymphopenia-Induced Proliferation of Naive T Cells in Transient States of Lymphopenia.
C. Bourgeois and B. Stockinger (2006)
J. Immunol. 177, 4558-4566
   Abstract »    Full Text »    PDF »
Dendritic Cell Modulation by Mast Cells Controls the Th1/Th2 Balance in Responding T Cells.
A. Mazzoni, R. P. Siraganian, C. A. Leifer, and D. M. Segal (2006)
J. Immunol. 177, 3577-3581
   Abstract »    Full Text »    PDF »
CD100 Enhances Dendritic Cell and CD4+ Cell Activation Leading to Pathogenetic Humoral Responses and Immune Complex Glomerulonephritis..
M. Li, K. M. O'Sullivan, L. K. Jones, T. Semple, A. Kumanogoh, H. Kikutani, S. R. Holdsworth, and A. R. Kitching (2006)
J. Immunol. 177, 3406-3412
   Abstract »    Full Text »    PDF »
Dietary Fish Oil Inhibits Antigen-Specific Murine Th1 Cell Development by Suppression of Clonal Expansion.
P. Zhang, W. Kim, L. Zhou, N. Wang, L. H. Ly, D. N. McMurray, and R. S. Chapkin (2006)
J. Nutr. 136, 2391-2398
   Abstract »    Full Text »    PDF »
Antigen-Experienced T Cells Limit the Priming of Naive T Cells during Infection with Leishmania major.
P. M. Gray, S. L. Reiner, D. F. Smith, P. M. Kaye, and P. Scott (2006)
J. Immunol. 177, 925-933
   Abstract »    Full Text »    PDF »
The Yersinia enterocolitica Invasin Protein Promotes Major Histocompatibility Complex Class I- and Class II-Restricted T-Cell Responses.
O. T. Buhler, C. A. Wiedig, Y. Schmid, G. A. Grassl, E. Bohn, and I. B. Autenrieth (2006)
Infect. Immun. 74, 4322-4329
   Abstract »    Full Text »    PDF »
G Protein-Coupled Receptor 83 Overexpression in Naive CD4+CD25- T Cells Leads to the Induction of Foxp3+ Regulatory T Cells In Vivo.
W. Hansen, K. Loser, A. M. Westendorf, D. Bruder, S. Pfoertner, C. Siewert, J. Huehn, S. Beissert, and J. Buer (2006)
J. Immunol. 177, 209-215
   Abstract »    Full Text »    PDF »
p300/Cyclic AMP-Responsive Element Binding-Binding Protein Mediates Transcriptional Coactivation by the CD28 T Cell Costimulatory Receptor.
S. L. Nandiwada, W. Li, R. Zhang, and D. L. Mueller (2006)
J. Immunol. 177, 401-413
   Abstract »    Full Text »    PDF »


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