Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.
University of Rostock

Site Tools

  • AAAS
  • Subscribe
  • Feedback

Site Search

Search Advanced

Science 7 December 1990:
Vol. 250. no. 4986, pp. 1403 - 1406
DOI: 10.1126/science.2255909
Prev | Table of Contents | Next

Articles

Science, Vol 250, Issue 4986, 1403-1406
Copyright © 1990 by American Association for the Advancement of Science

articles

Identification of a specialized adenylyl cyclase that may mediate odorant detection

HA Bakalyar and RR Reed

Department of Molecular Biology and Genetics, Howard Hughes Medical Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21205.

The mammalian olfactory system may transduce odorant information via a G protein-mediated adenosine 3',5'-monophosphate (cAMP) cascade. A newly discovered adenylyl cyclase, termed type III, has been cloned, and its expression was localized to olfactory neurons. The type III protein resides in the sensory neuronal cilia, which project into the nasal lumen and are accessible to airborne odorants. The enzymatic activity of the type III adenylyl cyclase appears to differ from nonsensory cyclases. The large difference seen between basal and stimulated activity for the type III enzyme could allow considerable modulation of the intracellular cAMP concentration. This property may represent one mechanism of achieving sensitivity in odorant perception.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
The Electrochemical Basis of Odor Transduction in Vertebrate Olfactory Cilia.
S. J. Kleene (2008)
Chem Senses
   Abstract »    Full Text »    PDF »
Distribution, Amplification, and Summation of Cyclic Nucleotide Sensitivities within Single Olfactory Sensory Cilia.
H. Takeuchi and T. Kurahashi (2008)
J. Neurosci. 28, 766-775
   Abstract »    Full Text »    PDF »
Mechanisms of neuronal chloride accumulation in intact mouse olfactory epithelium.
W. T. Nickell, N. K. Kleene, and S. J. Kleene (2007)
J. Physiol. 583, 1005-1020
   Abstract »    Full Text »    PDF »
Contribution of the receptor guanylyl cyclase GC-D to chemosensory function in the olfactory epithelium.
T. Leinders-Zufall, R. E. Cockerham, S. Michalakis, M. Biel, D. L. Garbers, R. R. Reed, F. Zufall, and S. D. Munger (2007)
PNAS 104, 14507-14512
   Abstract »    Full Text »    PDF »
Organization and Ca2+ Regulation of Adenylyl Cyclases in cAMP Microdomains.
D. Willoughby and D. M. F. Cooper (2007)
Physiol Rev 87, 965-1010
   Abstract »    Full Text »    PDF »
Absence of Adenylyl Cyclase 3 Perturbs Peripheral Olfactory Projections in Mice.
D.-J. Zou, A. T. Chesler, C. E. Le Pichon, A. Kuznetsov, X. Pei, E. L. Hwang, and S. Firestein (2007)
J. Neurosci. 27, 6675-6683
   Abstract »    Full Text »    PDF »
Introduction of bisecting GlcNAc in N-glycans of adenylyl cyclase III enhances its activity.
W. Li, M. Takahashi, Y. Shibukawa, S. Yokoe, J. Gu, E. Miyoshi, K. Honke, Y. Ikeda, and N. Taniguchi (2007)
Glycobiology 17, 655-662
   Abstract »    Full Text »    PDF »
Mutations in Olfactory Signal Transduction Genes Are Not a Major Cause of Human Congenital General Anosmia.
E. Feldmesser, D. Bercovich, N. Avidan, S. Halbertal, L. Haim, R. Gross-Isseroff, S. Goshen, and D. Lancet (2007)
Chem Senses 32, 21-30
   Abstract »    Full Text »    PDF »
Neuronal Chloride Accumulation in Olfactory Epithelium of Mice Lacking NKCC1.
W. T. Nickell, N. K. Kleene, R. C. Gesteland, and S. J. Kleene (2006)
J Neurophysiol 95, 2003-2006
   Abstract »    Full Text »    PDF »
Mechanism of Signal Amplification in the Olfactory Sensory Cilia.
H. Takeuchi and T. Kurahashi (2005)
J. Neurosci. 25, 11084-11091
   Abstract »    Full Text »    PDF »
Distinct Roles of Calcineurin-Nuclear Factor of Activated T-Cells and Protein Kinase A-cAMP Response Element-Binding Protein Signaling in Presynaptic Differentiation.
T. Yoshida and M. Mishina (2005)
J. Neurosci. 25, 3067-3079
   Abstract »    Full Text »    PDF »
Particulate Adenylate Cyclase Plays a Key Role in Human Sperm Olfactory Receptor-mediated Chemotaxis.
M. Spehr, K. Schwane, J. A. Riffell, J. Barbour, R. K. Zimmer, E. M. Neuhaus, and H. Hatt (2004)
J. Biol. Chem. 279, 40194-40203
   Abstract »    Full Text »    PDF »
Odorant Responses of Dual Polarity Are Mediated by cAMP in Mouse Olfactory Sensory Neurons.
R. Delay and D. Restrepo (2004)
J Neurophysiol 92, 1312-1319
   Abstract »    Full Text »    PDF »
A Dominant Negative G{alpha}s Mutant That Prevents Thyroid-stimulating Hormone Receptor Activation of cAMP Production and Inositol 1,4,5-Trisphosphate Turnover: COMPETITION BY DIFFERENT G PROTEINS FOR ACTIVATION BY A COMMON RECEPTOR.
J. H. Cleator, R. Ravenell, D. T. Kurtz, and J. D. Hildebrandt (2004)
J. Biol. Chem. 279, 36601-36607
   Abstract »    Full Text »    PDF »
Dopamine Reduces Odor- and Elevated-K+-Induced Calcium Responses in Mouse Olfactory Receptor Neurons In Situ.
C. C. Hegg and M. T. Lucero (2004)
J Neurophysiol 91, 1492-1499
   Abstract »    Full Text »    PDF »
First messenger regulation of capacitation via G protein-coupled mechanisms: a tale of serendipity and discovery.
L. R. Fraser, S. A. Adeoya-Osiguwa, and R. W. Baxendale (2003)
Mol. Hum. Reprod. 9, 739-748
   Abstract »    Full Text »    PDF »
Contribution of Cyclic-Nucleotide-Gated Channels to the Resting Conductance of Olfactory Receptor Neurons.
R. Y. K. Pun and S. J. Kleene (2003)
Biophys. J. 84, 3425-3435
   Abstract »    Full Text »    PDF »
Calmodulin-Regulated Adenylyl Cyclases: Cross-Talk and Plasticity in the Central Nervous System.
H. Wang and D. R. Storm (2003)
Mol. Pharmacol. 63, 463-468
   Abstract »    Full Text »    PDF »
Olfactory Signal Transduction in the Mouse Septal Organ.
M. Ma, X. Grosmaitre, C. L. Iwema, H. Baker, C. A. Greer, and G. M. Shepherd (2003)
J. Neurosci. 23, 317-324
   Abstract »    Full Text »    PDF »
Localization of Adenylyl Cyclase Isoforms and G Protein-Coupled Receptors in Vascular Smooth Muscle Cells: Expression in Caveolin-Rich and Noncaveolin Domains.
R. S. Ostrom, X. Liu, B. P. Head, C. Gregorian, T. M. Seasholtz, and P. A. Insel (2002)
Mol. Pharmacol. 62, 983-992
   Abstract »    Full Text »    PDF »
Stomatin-Related Olfactory Protein, SRO, Specifically Expressed in the Murine Olfactory Sensory Neurons.
K. Kobayakawa, R. Hayashi, K. Morita, K. Miyamichi, Y. Oka, A. Tsuboi, and H. Sakano (2002)
J. Neurosci. 22, 5931-5937
   Abstract »    Full Text »    PDF »
Leukemia inhibitory factor inhibits neuronal terminal differentiation through STAT3 activation.
C. Moon, J.-Y. Yoo, V. Matarazzo, Y. K. Sung, E. J. Kim, and G. V. Ronnett (2002)
PNAS 99, 9015-9020
   Abstract »    Full Text »    PDF »
Activation of adenylyl cyclases, regulation of insulin status, and cell survival by Galpha olf in pancreatic beta -cells.
K. L. Regnauld, E. Leteurtre, S. J. Gutkind, C. P. Gespach, and S. Emami (2002)
Am J Physiol Regulatory Integrative Comp Physiol 282, R870-R880
   Abstract »    Full Text »    PDF »
Type-specific Regulation of Adenylyl Cyclase. SELECTIVE PHARMACOLOGICAL STIMULATION AND INHIBITION OF ADENYLYL CYCLASE ISOFORMS.
T. Onda, Y. Hashimoto, M. Nagai, H. Kuramochi, S. Saito, H. Yamazaki, Y. Toya, I. Sakai, C. J. Homcy, K. Nishikawa, et al. (2001)
J. Biol. Chem. 276, 47785-47793
   Abstract »    Full Text »    PDF »
Protein Associated with Myc (PAM) Is a Potent Inhibitor of Adenylyl Cyclases.
K. Scholich, S. Pierre, and T. B. Patel (2001)
J. Biol. Chem. 276, 47583-47589
   Abstract »    Full Text »    PDF »
Odorant-induced Hyperpolarization and Suppression of cAMP-activated Current in Newt Olfactory Receptor Neurons.
H. Yamada and K. Nakatani (2001)
Chem Senses 26, 25-34
   Abstract »    Full Text »    PDF »
A cGMP-signaling pathway in a subset of olfactory sensory neurons.
M. R. Meyer, A. Angele, E. Kremmer, U. B. Kaupp, and F. Muller (2000)
PNAS 97, 10595-10600
   Abstract »    Full Text »    PDF »
Tissue specificity and physiological relevance of various isoforms of adenylyl cyclase.
N. Defer, M. Best-Belpomme, and J. Hanoune (2000)
Am J Physiol Renal Physiol 279, F400-F416
   Abstract »    Full Text »    PDF »
Isolation and In Vitro Differentiation of Conditionally Immortalized Murine Olfactory Receptor Neurons.
R. D. Barber, D. E. Jaworsky, K.-W. Yau, and G. V. Ronnett (2000)
J. Neurosci. 20, 3695-3704
   Abstract »    Full Text »    PDF »
Expression of Adenylate Cyclase Subtypes II and IV in the Human Outflow Pathway.
X. Zhang, N. Wang, A. Schroeder, and K. A. Erickson (2000)
Invest. Ophthalmol. Vis. Sci. 41, 998-1005
   Abstract »    Full Text »
Physiological Regulation of G Protein-Linked Signaling.
A. J. Morris and C. C. Malbon (1999)
Physiol Rev 79, 1373-1430
   Abstract »    Full Text »    PDF »
Regions on adenylyl cyclase that are necessary for inhibition of activity by beta gamma and Gialpha subunits of heterotrimeric G proteins.
C. Wittpoth, K. Scholich, Y. Yigzaw, T. M. Stringfield, and T. B. Patel (1999)
PNAS 96, 9551-9556
   Abstract »    Full Text »    PDF »
The Native Rat Olfactory Cyclic Nucleotide-Gated Channel Is Composed of Three Distinct Subunits.
W. Bonigk, J. Bradley, F. Muller, F. Sesti, I. Boekhoff, G. V. Ronnett, U. B. Kaupp, and S. Frings (1999)
J. Neurosci. 19, 5332-5347
   Abstract »    Full Text »    PDF »
Cellular and Subcellular Expression of Golf/Gs and Gq/G11 {alpha}-Subunits in Rat Pancreatic Endocrine Cells.
A. Astesano, K. Regnauld, N. Ferrand, D. Gingras, M. Bendayan, G. Rosselin, and S. Emami (1999)
J. Histochem. Cytochem. 47, 289-302
   Abstract »    Full Text »
Regulation and Immunohistochemical Localization of beta gamma -Stimulated Adenylyl Cyclases in Mouse Hippocampus.
L. P. Baker, M. D. Nielsen, S. Impey, B. M. Hacker, S. W. Poser, M. Y. M. Chan, and D. R. Storm (1999)
J. Neurosci. 19, 180-192
   Abstract »    Full Text »    PDF »
Identification of a Gialpha Binding Site on Type V Adenylyl Cyclase.
C. W. Dessauer, J. J. G. Tesmer, S. R. Sprang, and A. G. Gilman (1998)
J. Biol. Chem. 273, 25831-25839
   Abstract »    Full Text »    PDF »
A Depolarizing Chloride Current Contributes to Chemoelectrical Transduction in Olfactory Sensory Neurons In Situ.
D. Reuter, K. Zierold, W. H. Schroder, and S. Frings (1998)
J. Neurosci. 18, 6623-6630
   Abstract »    Full Text »    PDF »
Stimulation of Type 1 and Type 8 Ca2+/Calmodulin-sensitive Adenylyl Cyclases by the Gs-coupled 5-Hydroxytryptamine Subtype 5-HT7A Receptor.
L. P. Baker, M. D. Nielsen, S. Impey, M. A. Metcalf, S. W. Poser, G. Chan, K. Obrietan, M. W. Hamblin, and D. R. Storm (1998)
J. Biol. Chem. 273, 17469-17476
   Abstract »    Full Text »    PDF »
The Olfactory Adenylyl Cyclase III Is Expressed in Rat Germ Cells during Spermiogenesis.
C. Gautier-Courteille, M. Salanova, and M. Conti (1998)
Endocrinology 139, 2588-2599
   Abstract »    Full Text »    PDF »
Calcium-Sensitive Particulate Guanylyl Cyclase as a Modulator of cAMP in Olfactory Receptor Neurons.
C. Moon, P. Jaberi, A. Otto-Bruc, W. Baehr, K. Palczewski, and G. V. Ronnett (1998)
J. Neurosci. 18, 3195-3205
   Abstract »    Full Text »    PDF »
Phosphorylation of Mammalian Olfactory Cyclic Nucleotide-Gated Channels Increases Ligand Sensitivity.
F. Muller, W. Bonigk, F. Sesti, and S. Frings (1998)
J. Neurosci. 18, 164-173
   Abstract »    Full Text »    PDF »
Suppression of cAMP by phosphoinositol/Ca2+ pathway in the cardiac kappa -opioid receptor.
W.-M. Zhang and T.-M. Wong (1998)
Am J Physiol Cell Physiol 274, C82-C87
   Abstract »    Full Text »    PDF »
Cloning and Functional Characterization of Roaz, a Zinc Finger Protein that Interacts with O/E-1 to Regulate Gene Expression: Implications for Olfactory Neuronal Development.
R. Y. L. Tsai and R. R. Reed (1997)
J. Neurosci. 17, 4159-4169
   Abstract »    Full Text »    PDF »
The Conserved Asparagine and Arginine Are Essential for Catalysis of Mammalian Adenylyl Cyclase.
S.-Z. Yan, Z.-H. Huang, R. S. Shaw, and W.-J. Tang (1997)
J. Biol. Chem. 272, 12342-12349
   Abstract »    Full Text »    PDF »
Characterization of soluble forms of nonchimeric type V adenylyl cyclases.
K. Scholich, A. J. Barbier, J. B. Mullenix, and T. B. Patel (1997)
PNAS 94, 2915-2920
   Abstract »    Full Text »    PDF »
A subset of olfactory neurons that selectively express cGMP-stimulated phosphodiesterase (PDE2) and guanylyl cyclase-D define a unique olfactory signal transduction pathway.
D. M. Juilfs, H.-J. Fulle, A. Z. Zhao, M. D. Houslay, D. L. Garbers, and J. A. Beavo (1997)
PNAS 94, 3388-3395
   Abstract »    Full Text »    PDF »
The Adenylyl Cyclases as Integrators of Transmembrane Signal Transduction.
Y. Ishikawa and C. J. Homcy (1997)
Circ. Res. 80, 297-304
   Full Text »
Opiate-induced Adenylyl Cyclase Superactivation Is Isozyme-specific.
T. Avidor-Reiss, I. Nevo, D. Saya, M. Bayewitch, and Z. Vogel (1997)
J. Biol. Chem. 272, 5040-5047
   Abstract »    Full Text »    PDF »
Olfactory Dysfunction in Type I Pseudohypoparathyroidism: Dissociation from Gs{alpha} Protein Deficiency.
R. L. Doty, A. D. Fernandez, M. A. Levine, A. Moses, and D. A. McKeown (1997)
J. Clin. Endocrinol. Metab. 82, 247-250
   Abstract »    Full Text »    PDF »
Phosphorylation and Inhibition of Type III Adenylyl Cyclase by Calmodulin-dependent Protein Kinase II in Vivo.
J. Wei, G. Wayman, and D. R. Storm (1996)
J. Biol. Chem. 271, 24231-24235
   Abstract »    Full Text »    PDF »
Constitutively Active Adenylyl Cyclase Mutant Requires Neither G Proteins nor Cytosolic Regulators.
C. A. Parent and P. N. Devreotes (1996)
J. Biol. Chem. 271, 18333-18336
   Abstract »    Full Text »    PDF »
Electrophysiological Characterization of Chemosensory Neurons from the Mouse Vomeronasal Organ.
E. R. Liman and D. P. Corey (1996)
J. Neurosci. 16, 4625-4637
   Abstract »    Full Text »    PDF »
Identification and Characterization of a Widely Expressed Form of Adenylyl Cyclase.
R. T. Premont, I. Matsuoka, M.-G. Mattei, Y. Pouille, N. Defer, and J. Hanoune (1996)
J. Biol. Chem. 271, 13900-13907
   Abstract »    Full Text »    PDF »
Two Cytoplasmic Domains of Mammalian Adenylyl Cyclase Form a G[IMAGE]- and Forskolin-activated Enzyme in Vitro.
S.-Z. Yan, D. Hahn, Z.-H. Huang, and W.-J. Tang (1996)
J. Biol. Chem. 271, 10941-10945
   Abstract »    Full Text »    PDF »
Splice Variants of Type VIII Adenylyl Cyclase.
J. J. Cali, R. S. Parekh, and J. Krupinski (1996)
J. Biol. Chem. 271, 1089-1095
   Abstract »    Full Text »    PDF »
Hormone Stimulation of Type III Adenylyl Cyclase Induces Ca[IMAGE] Oscillations in HEK-293 Cells.
G. A. Wayman, T. R. Hinds, and D. R. Storm (1995)
J. Biol. Chem. 270, 24108-24115
   Abstract »    Full Text »    PDF »
Ca[IMAGE] Inhibition of Type III Adenylyl Cyclase in Vivo.
G. A. Wayman, S. Impey, and D. R. Storm (1995)
J. Biol. Chem. 270, 21480-21486
   Abstract »    Full Text »    PDF »
Distinct Characteristics of the Basal Activities of Adenylyl Cyclases 2 and 6.
J. P. Pieroni, A. Harry, J. Chen, O. Jacobowitz, R. P. Magnusson, and R. Iyengar (1995)
J. Biol. Chem. 270, 21368-21373
   Abstract »    Full Text »    PDF »
Voltage-sensitive Adenylyl Cyclase Activity in Cultured Neurons.
R. Reddy, D. Smith, G. Wayman, Z. Wu, E. C. Villacres, and D. R. Storm (1995)
J. Biol. Chem. 270, 14340-14346
   Abstract »    Full Text »    PDF »
Decreased Adenylate Cyclase Activity and Expression of Gs{alpha} in Human Myocardium After Orthotopic Cardiac Transplantation.
E. Loh, J. V. Barnett, A. M. Feldman, G. S. Couper, D. E. Vatner, W. S. Colucci, and J. B. Galper (1995)
Circ. Res. 76, 852-860
   Abstract »    Full Text »
Mutational Inactivation of the Catalytic Domain of Guanylate Cyclase-A Receptor.
Z.-H. Miao, D.-L. Song, J. G. Douglas, and C.-H. Chang (1995)
Hypertension 25, 694-698
   Abstract »    Full Text »
Evidence for Gbeta[IMAGE]-mediated Cross-talk in Primary Cultures of Lung Alveolar Cells.
M. S. Pian and L. G. Dobbs (1995)
J. Biol. Chem. 270, 7427-7430
   Abstract »    Full Text »    PDF »
Identification of Functional Domains of Adenylyl Cyclase Using in Vivo Chimeras.
L. R. Levin and R. R. Reed (1995)
J. Biol. Chem. 270, 7573-7579
   Abstract »    Full Text »    PDF »
A Novel GTP-binding Protein [IMAGE]-Subunit, G[IMAGE]8, Is Expressed during Neurogenesis in the Olfactory and Vomeronasal Neuroepithelia.
N. J. P. Ryba and R. Tirindelli (1995)
J. Biol. Chem. 270, 6757-6767
   Abstract »    Full Text »    PDF »
Mammalian Membrane-bound Adenylyl Cyclases.
R. Taussig and A. G. Gilman (1995)
J. Biol. Chem. 270, 1-4
   Full Text »    PDF »
Dominant Negative Mutations of the Guanylyl Cyclase-A Receptor.
D. K. Thompson and D. L. Garbers (1995)
J. Biol. Chem. 270, 425-430
   Abstract »    Full Text »    PDF »
Suppression of odorant responses by odorants in olfactory receptor cells.
T Kurahashi, G Lowe, and G. Gold (1994)
Science 265, 118-120
   Abstract »    PDF »
Beta-adrenergic receptor kinase-2 and beta-arrestin-2 as mediators of odorant-induced desensitization.
T. Dawson, J. Arriza, D. Jaworsky, F. Borisy, H Attramadal, R. Lefkowitz, and G. Ronnett (1993)
Science 259, 825-829
   Abstract »    PDF »
Type-specific regulation of adenylyl cyclase by G protein beta gamma subunits.
W. Tang and A. Gilman (1991)
Science 254, 1500-1503
   Abstract »    PDF »
Guanylyl Cyclase Activity Associated with Putative Bifunctional Integral Membrane Proteins in Plasmodium falciparum.
D. J. Carucci, A. A. Witney, D. K. Muhia, D. C. Warhurst, P. Schaap, M. Meima, J.-L. Li, M. C. Taylor, J. M. Kelly, and D. A. Baker (2000)
J. Biol. Chem. 275, 22147-22156
   Abstract »    Full Text »    PDF »
A Possible Role for Caveolin as a Signaling Organizer in Olfactory Sensory Membranes.
S. Schreiber, J. Fleischer, H. Breer, and I. Boekhoff (2000)
J. Biol. Chem. 275, 24115-24123
   Abstract »    Full Text »    PDF »
Kinesin-II Is Required for Flagellar Sensory Transduction during Fertilization in Chlamydomonas.
J. Pan and W. J. Snell (2002)
Mol. Biol. Cell 13, 1417-1426
   Abstract »    Full Text »    PDF »


ADVERTISEMENT
Click Me!

ADVERTISEMENT
Click Me!

To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)