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Science 7 December 1990: Vol. 250. no. 4986, pp. 1370 - 1377 DOI: 10.1126/science.2175046
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Articles
Science, Vol 250, Issue 4986, 1370-1377
Copyright © 1990 by American Association for the Advancement of Science
Spacing differentiation in the developing Drosophila eye: a fibrinogen-related lateral inhibitor encoded by scabrous
NE Baker,
M Mlodzik,
and
GM Rubin
Howard Hughes Medical Institute, University of California, Berkeley 94720.
In the development of multicellular organisms a diversity of cell types differentiate at specific positions. Spacing patterns, in which an array of two or more cell types forms from a uniform field of cells, are a common feature of development. Identical precursor cells may adopt different fates because of competition and inhibition between them. Such a pattern in the developing Drosophila eye is the evenly spaced array of R8 cells, around which other cell types are subsequently recruited. Genetic studies suggest that the scabrous mutation disrupts a signal produced by R8 cells that inhibits other cells from also becoming R8 cells. The scabrous locus was cloned, and it appears to encode a secreted protein partly related to the beta and gamma chains of fibrinogen. It is proposed that the sca locus encodes a lateral inhibitor of R8 differentiation. The roles of the Drosophila EGF-receptor homologue (DER) and Notch genes in this process were also investigated.
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