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Science 30 November 1990:
Vol. 250. no. 4985, pp. 1259 - 1262
DOI: 10.1126/science.2244209
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Articles

Science, Vol 250, Issue 4985, 1259-1262
Copyright © 1990 by American Association for the Advancement of Science

articles

Binding of the Wilms' tumor locus zinc finger protein to the EGR-1 consensus sequence

FJ Rauscher 3rd, JF Morris, OE Tournay, DM Cook, and T Curran

Wistar Institute, Philadelphia, PA 19104.

The Wilms' tumor locus (WTL) at 11p13 contains a gene that encodes a zinc finger-containing protein that has characteristics of a DNA-binding protein. However, binding of this protein to DNA in a sequence-specific manner has not been demonstrated. A synthetic gene was constructed that contained the zinc finger region, and the protein was expressed in Escherichia coli. The recombinant protein was used to identify a specific DNA binding site from a pool of degenerate oligonucleotides. The binding sites obtained were similar to the sequence recognized by the early growth response-1 (EGR-1) gene product, a zinc finger-containing protein that is induced by mitogenic stimuli. A mutation in the zinc finger region of the protein originally identified in a Wilms' tumor patient abolished its DNA-binding activity. These results suggest that the WTL protein may act at the DNA binding site of a growth factor-inducible gene and that loss of DNA-binding activity contributes to the tumorigenic process.


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J.-Y. Li, M. A. English, H. J. Ball, P. L. Yeyati, S. Waxman, and J. D. Licht (1997)
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Altered expression of the WT1 Wilms tumor suppressor gene in human breast cancer.
G. B. Silberstein, K. Van Horn, P. Strickland, C. T. Roberts Jr., and C. W. Daniel (1997)
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R. Sundseth, G. Macdonald, J. Ting, and A. C. King (1997)
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E. Karnieli, H. Werner, F. J. Rauscher III, L. E. Benjamin, and D. LeRoith (1996)
J. Biol. Chem. 271, 19304-19309
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Differential Function of Wilms' Tumor Gene WT1 Splice Isoforms in Transcriptional Regulation.
S. M. Hewitt, G. C. Fraizer, Y.-J. Wu, F. J. Rauscher III, and G. F. Saunders (1996)
J. Biol. Chem. 271, 8588-8592
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A Non-AUG Translational Initiation Event Generates Novel WT1 Isoforms.
W. Bruening and J. Pelletier (1996)
J. Biol. Chem. 271, 8646-8654
   Abstract »    Full Text »    PDF »
The Transcriptional Effect of WT1 Is Modulated by Choice of Expression Vector.
J. C. Reddy, S. Hosono, and J. D. Licht (1995)
J. Biol. Chem. 270, 29976-29982
   Abstract »    Full Text »    PDF »
Interplay of Sp1 and Egr-1 in the Proximal Platelet-derived Growth Factor A-Chain Promoter in Cultured Vascular Endothelial Cells.
L. M. Khachigian, A. J. Williams, and T. Collins (1995)
J. Biol. Chem. 270, 27679-27686
   Abstract »    Full Text »    PDF »
Repression of the c-myb Gene by WT1 Protein in T and B Cell Lines.
S. McCann, J. Sullivan, J. Guerra, M. Arcinas, and L. M. Boxer (1995)
J. Biol. Chem. 270, 23785-23789
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S Maheswaran, C Englert, P Bennett, G Heinrich, and D A Haber (1995)
Genes & Dev. 9, 2143-2156
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WT1-mediated Transcriptional Activation Is Inhibited by Dominant Negative Mutant Proteins.
J. C. Reddy, J. C. Morris, J. Wang, M. A. English, D. A. Haber, Y. Shi, and J. D. Licht (1995)
J. Biol. Chem. 270, 10878-10884
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Identification of a Nuclear Factor-I Family Protein-binding Site in the Silencer Region of the Cartilage Matrix Protein Gene.
P. Szabó, J. Moitra, A. Rencendorj, Gáb. Rákhely, T. Rauch, and I. Kiss (1995)
J. Biol. Chem. 270, 10212-10221
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Characterization of the Human Inosine-5`-monophosphate Dehydrogenase Type II Gene.
A. G. Zimmermann, J. Spychala, and B. S. Mitchell (1995)
J. Biol. Chem. 270, 6808-6814
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Promoter Elements of the Mouse Acetylcholinesterase Gene.
A. Mutero, S. Camp, and P. Taylor (1995)
J. Biol. Chem. 270, 1866-1872
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Repression of Pax-2 by WT1 during normal kidney development.
G Ryan, V Steele-Perkins, J. Morris, F. Rauscher, and G. Dressler (1995)
Development 121, 867-875
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RNA editing in the Wilms' tumor susceptibility gene, WT1..
P M Sharma, M Bowman, S L Madden, F J Rauscher, and S Sukumar (1994)
Genes & Dev. 8, 720-731
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Egr3/Pilot, a zinc finger transcription factor, is rapidly regulated by activity in brain neurons and colocalizes with Egr1/zif268..
K Yamagata, W E Kaufmann, A Lanahan, M Papapavlou, C A Barnes, K I Andreasson, and P F Worley (1994)
Learn. Mem. 1, 140-152
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WT1-mediated growth suppression of Wilms tumor cells expressing a WT1 splicing variant.
D. Haber, S Park, S Maheswaran, C Englert, G. Re, D. Hazen-Martin, D. Sens, and A. Garvin (1993)
Science 262, 2057-2059
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Nuclear localization of the protein encoded by the Wilms' tumor gene WT1 in embryonic and adult tissues.
S. Mundlos, J. Pelletier, A. Darveau, M. Bachmann, A. Winterpacht, and B. Zabel (1993)
Development 119, 1329-1341
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Crystal structure of a five-finger GLI-DNA complex: new perspectives on zinc fingers.
N. Pavletich and C. Pabo (1993)
Science 261, 1701-1707
   Abstract »    PDF »
Sequence discrimination by alternatively spliced isoforms of a DNA binding zinc finger domain.
J. Gogos, T Hsu, J Bolton, and F. Kafatos (1992)
Science 257, 1951-1955
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Repression of the insulin-like growth factor II gene by the Wilms tumor suppressor WT1.
I. Drummond, S. Madden, P Rohwer-Nutter, G. Bell, V. Sukhatme, and F. Rauscher 3rd (1992)
Science 257, 674-678
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Modulation of DNA binding specificity by alternative splicing of the Wilms tumor wt1 gene transcript.
W. Bickmore, K Oghene, M. Little, A Seawright, V van Heyningen, and N. Hastie (1992)
Science 257, 235-237
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Identification of a zinc finger protein that inhibits IL-2 gene expression.
T. Williams, D Moolten, J Burlein, J Romano, R Bhaerman, A Godillot, M Mellon, F. Rauscher 3rd, and J. Kant (1991)
Science 254, 1791-1794
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Tumor suppressor genes.
R. Weinberg (1991)
Science 254, 1138-1146
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Transcriptional repression mediated by the WT1 Wilms tumor gene product.
S. Madden, D. Cook, J. Morris, A Gashler, V. Sukhatme, and F. Rauscher III (1991)
Science 253, 1550-1553
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Expression of the Wilms' tumor gene WT1 in the murine urogenital system..
J Pelletier, M Schalling, A J Buckler, A Rogers, D A Haber, and D Housman (1991)
Genes & Dev. 5, 1345-1356
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The Gut-enriched Kruppel-like Factor (Kruppel-like Factor 4) Mediates the Transactivating Effect of p53 on the p21WAF1/Cip1 Promoter.
W. Zhang, D. E. Geiman, J. M. Shields, D. T. Dang, C. S. Mahatan, K. H. Kaestner, J. R. Biggs, A. S. Kraft, and V. W. Yang (2000)
J. Biol. Chem. 275, 18391-18398
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Identification of Connective Tissue Growth Factor as a Target of WT1 Transcriptional Regulation.
P. Stanhope-Baker and B. R. G. Williams (2000)
J. Biol. Chem. 275, 38139-38150
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Ionizing Radiation Down-regulates p53 Protein in Primary Egr-1-/- Mouse Embryonic Fibroblast Cells Causing Enhanced Resistance to Apoptosis.
A. Das, D. Chendil, S. Dey, M. Mohiuddin, M. Mohiuddin, J. Milbrandt, V. M. Rangnekar, and M. M. Ahmed (2001)
J. Biol. Chem. 276, 3279-3286
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A. Hossain and G. F. Saunders (2001)
J. Biol. Chem. 276, 16817-16823
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