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Science 23 November 1990:
Vol. 250. no. 4984, pp. 1104 - 1110
DOI: 10.1126/science.2174572
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Articles

Science, Vol 250, Issue 4984, 1104-1110
Copyright © 1990 by American Association for the Advancement of Science

articles

Differences and similarities in DNA-binding preferences of MyoD and E2A protein complexes revealed by binding site selection

TK Blackwell and H Weintraub

Department of Genetics, Fred Hutchinson Cancer Research Center, Seattle, WA.

A technique was developed for studying protein-DNA recognition that can be applied to any purified protein, partially purified protein, or cloned gene. From oligonucleotides in which particular positions are of random sequence, that subset to which a given protein binds is amplified by the polymerase chain reaction and sequenced as a pool. These selected and amplified binding site (SAAB) "imprints" provide a characteristic set of preferred sequences for protein binding. With this technique, it was shown that homo- and heterooligomers of the helix-loop-helix proteins MyoD and E2A recognize a common consensus sequence, CA--TG, but otherwise bind to flanking and internal positions with different sequence preferences that suggest half-site recognition. These findings suggest that different combinations of dimeric proteins can have different binding sequence preferences.


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Specific Protein-Protein Interaction between Basic Helix-Loop-Helix Transcription Factors and Homeoproteins of the Pitx Family.
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Direct Targeting of Light Signals to a Promoter Element-Bound Transcription Factor.
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Unloading induces transcriptional activation of the sarco(endo)plasmic reticulum Ca2+-ATPase 1 gene in muscle.
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Development 126, 1957-1965
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MRG1, the product of a melanocyte-specific gene related gene, is a cytokine-inducible transcription factor with transformation activity.
H. B. Sun, Y. X. Zhu, T. Yin, G. Sledge, and Y.-C. Yang (1998)
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J. V. O'Mahoney, K. L. Guven, J. Lin, J. E. Joya, C. S. Robinson, R. P. Wade, and E. C. Hardeman (1998)
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J. Huang, H. Weintraub, and L. Kedes (1998)
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S. T. Estrem, T. Gaal, W. Ross, and R. L. Gourse (1998)
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