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Science 16 November 1990:
Vol. 250. no. 4983, pp. 1000 - 1002
DOI: 10.1126/science.2173143
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Articles

Science, Vol 250, Issue 4983, 1000-1002
Copyright © 1990 by American Association for the Advancement of Science

articles

Hyperkalemic periodic paralysis and the adult muscle sodium channel alpha-subunit gene

B Fontaine, TS Khurana, EP Hoffman, GA Bruns, JL Haines, JA Trofatter, MP Hanson, J Rich, H McFarlane, DM Yasek, and al. et

Molecular Neurogenetics Laboratory, Massachusetts General Hospital, Charlestown, MA 02129.

Hyperkalemic periodic paralysis (HYPP) is an autosomal dominant disorder characterized by episodes of muscle weakness due to depolarization of the muscle cell membrane associated with elevated serum potassium. Electrophysiological studies have implicated the adult muscle sodium channel. Here, portions of the adult muscle sodium channel alpha-subunit gene were cloned and mapped near the human growth hormone locus (GH1) on chromosome 17. In a large pedigree displaying HYPP with myotonia, these two loci showed tight linkage to the genetic defect with no recombinants detected. Thus, it is likely that the sodium channel alpha-subunit gene contains the HYPP mutation.


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