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Science 9 November 1990:
Vol. 250. no. 4982, pp. 820 - 823
DOI: 10.1126/science.2237433
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Articles
Science, Vol 250, Issue 4982, 820-823
Copyright © 1990 by American Association for the Advancement of Science
Analysis of junctional diversity during B lymphocyte development
K Meek
Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas 75235.
Immunoglobulin rearrangement is central to generating antibody diversity because of heterogeneity generated during recombination by deletion or addition of nucleotides at coding joints by the recombinase machinery. Examination of these junctional modifications revealed that the addition of nongermline-encoded nucleotides was more prevalent in adult versus fetal B cells, thus partially limiting the fetal antibody repertoire. In contrast, deletion of nucleotides occurs equivalently in B cells at different stages of development and at different points in B cell ontogeny. Finally, the bias in murine immunoglobulins for one DH segment reading frame occurs at the DHJH intermediate.
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