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Science 26 October 1990:
Vol. 250. no. 4980, pp. 568 - 571
DOI: 10.1126/science.2122520
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Articles

Science, Vol 250, Issue 4980, 568-571
Copyright © 1990 by American Association for the Advancement of Science

articles

Restoration of inactivation in mutants of Shaker potassium channels by a peptide derived from ShB

WN Zagotta, T Hoshi, and RW Aldrich

Department of Molecular and Cellular Physiology, Stanford University School of Medicine, CA 94305.

Site-directed mutagenesis experiments have suggested a model for the inactivation mechanism of Shaker potassium channels from Drosophila melanogaster. In this model, the first 20 amino acids form a cytoplasmic domain that interacts with the open channel to cause inactivation. The model was tested by the internal application of a synthetic peptide, with the sequence of the first 20 residues of the ShB alternatively spliced variant, to noninactivating mutant channels expressed in Xenopus oocytes. The peptide restored inactivation in a concentration-dependent manner. Like normal inactivation, peptide-induced inactivation was not noticeably voltage-dependent. Trypsin-treated peptide and peptides with sequences derived from the first 20 residues of noninactivating mutants did not restore inactivation. These results support the proposal that inactivation occurs by a cytoplasmic domain that occludes the ion-conducting pore of the channel.


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   Abstract »    Full Text »    PDF »
Apoptotic proteins Reaper and Grim induce stable inactivation in voltage-gated K+ channels.
V. Avdonin, J. Kasuya, M. A. Ciorba, B. Kaplan, T. Hoshi, and L. Iverson (1998)
PNAS 95, 11703-11708
   Abstract »    Full Text »    PDF »
Reduced K+ Channel Inactivation, Spike Broadening, and After-Hyperpolarization in Kvbeta 1.1-Deficient Mice with Impaired Learning.
K. P. Giese, J. F. Storm, D. Reuter, N. B. Fedorov, L.-R. Shao, T. Leicher, O. Pongs, and A. J. Silva (1998)
Learn. Mem. 5, 257-273
   Abstract »    Full Text »
The Diphtheria Toxin Channel-forming T Domain Translocates Its Own NH2-Terminal Region Across Planar Bilayers.
L. Senzel, P. D. Huynh, K. S. Jakes, R. John Collier, and A. Finkelstein (1998)
J. Gen. Physiol. 112, 317-324
   Abstract »    Full Text »    PDF »


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