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Science 26 October 1990:
Vol. 250. no. 4980, pp. 562 - 565
DOI: 10.1126/science.1700476
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Articles

Science, Vol 250, Issue 4980, 562-565
Copyright © 1990 by American Association for the Advancement of Science

articles

Molecular cloning and functional expression of the cardiac sarcolemmal Na(+)-Ca2+ exchanger

DA Nicoll, S Longoni, and KD Philipson

Department of Medicine, UCLA School of Medicine 90024-1760.

The Na(+)-Ca2+ exchanger of the cardiac sarcolemma can rapidly transport Ca2+ during excitation-contraction coupling. To begin molecular studies of this transporter, polyclonal antibodies were used to identify a complementary DNA (cDNA) clone encoding the Na(+)-Ca2+ exchanger protein. The cDNA hybridizes with a 7-kilobase RNA on a Northern blot and has an open reading frame of 970 amino acids. Hydropathy analysis suggests that the protein has multiple transmembrane helices, and a small region of the sequence is similar to that of the Na(+)- and K(+)-dependent adenosine triphosphatase. Polyclonal antibodies to a synthetic peptide from the deduced amino acid sequence react with sarcolemmal proteins of 70, 120, and 160 kilodaltons on immunoblots. RNA, synthesized from the cDNA clone, induces expression of Na(+)-Ca2+ exchange activity when injected into Xenopus oocytes.


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J. Biol. Chem. 274, 23094-23102
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Sodium/Calcium Exchange: Its Physiological Implications.
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A New Topological Model of the Cardiac Sarcolemmal Na+-Ca2+ Exchanger.
D. A. Nicoll, M. Ottolia, L. Lu, Y. Lu, and K. D. Philipson (1999)
J. Biol. Chem. 274, 910-917
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Involvement of Na+/Ca2+ Exchanger in Inside-Out Signaling Through the Platelet Integrin alpha IIbbeta 3.
M. Shiraga, Y. Tomiyama, S. Honda, H. Suzuki, S. Kosugi, S. Tadokoro, Y. Kanakura, K. Tanoue, Y. Kurata, and Y. Matsuzawa (1998)
Blood 92, 3710-3720
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Overexpression of the Sarcolemmal Calcium Pump in the Myocardium of Transgenic Rats.
A. Hammes, S. Oberdorf-Maass, T. Rother, K. Nething, F. Gollnick, K. W. Linz, R. Meyer, K. Hu, H. Han, P. Gaudron, et al. (1998)
Circ. Res. 83, 877-888
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Na+ -Ca2+ exchange and sarcoplasmic reticular Ca2+ regulation in ventricular myocytes from transgenic mice overexpressing the Na+ -Ca2+ exchanger.
C. M N Terracciano, A. I De Souza, K. D Philipson, and K. T MacLeod (1998)
J. Physiol. 512, 651-667
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Differential inhibition of Na+/Ca2+ exchanger isoforms by divalent cations and isothiourea derivative.
T. Iwamoto and M. Shigekawa (1998)
Am J Physiol Cell Physiol 275, C423-C430
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Na+/Ca2+ exchange in neonatal rat heart cells: antisense inhibition and protein half-life.
M. K. Slodzinski and M. P. Blaustein (1998)
Am J Physiol Cell Physiol 275, C459-C467
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A Novel Molecular Determinant for cAMP-dependent Regulation of the Frog Heart Na+-Ca2+ Exchanger.
Y. M. Shuba, T. Iwata, V. G. Naidenov, M. Oz, K. Sandberg, A. Kraev, E. Carafoli, and M. Morad (1998)
J. Biol. Chem. 273, 18819-18825
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Regulation of Na+/Ca2+ exchange activity by cytosolic Ca2+ in transfected Chinese hamster ovary cells.
Y. Fang, M. Condrescu, and J. P. Reeves (1998)
Am J Physiol Cell Physiol 275, C50-C55
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Structure-Function Relationships and Localization of the Na/Ca-K Exchanger in Rod Photoreceptors.
T. S. Y. Kim, D. M. Reid, and R. S. Molday (1998)
J. Biol. Chem. 273, 16561-16567
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Cloning, Expression, and Characterization of the Squid Na+-Ca2+ Exchanger (NCX-SQ1).
Z. He, Q. Tong, B. D. Quednau, K. D. Philipson, and D. W. Hilgemann (1998)
J. Gen. Physiol. 111, 857-873
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Na+/Ca2+ exchange in catfish retina horizontal cells: regulation of intracellular Ca2+ store function.
M. A. Micci and B. N. Christensen (1998)
Am J Physiol Cell Physiol 274, C1625-C1633
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Structure-Function Analysis of CALX1.1, a Na+-Ca2+ Exchanger from Drosophila. MUTAGENESIS OF IONIC REGULATORY SITES.
C. Dyck, K. Maxwell, J. Buchko, M. Trac, A. Omelchenko, M. Hnatowich, and L. V. Hryshko (1998)
J. Biol. Chem. 273, 12981-12987
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Modifications of myocardial Na+,K+-ATPase isoforms and Na+/Ca2+ exchanger in aldosterone/salt-induced hypertension in guinea pigs.
J. F. Ramnrez-Gil, P. Trouve, N. Mougenot, A. Carayon, P. Lechat, and D. Charlemagne (1998)
Cardiovasc Res 38, 451-462
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Expression of the Na+/Ca2+ exchanger emerges in hepatic stellate cells after activation in association with liver fibrosis.
T. Nakamura, S. Arii, K. Monden, M. Furutani, Y. Takeda, M. Imamura, M. Tominaga, and Y. Okada (1998)
PNAS 95, 5389-5394
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