Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Science 12 October 1990:
Vol. 250. no. 4978, pp. 294 - 296
DOI: 10.1126/science.2145629
Prev | Table of Contents | Next

Articles

Science, Vol 250, Issue 4978, 294-296
Copyright © 1990 by American Association for the Advancement of Science

articles

Induction of a neuronal proteoglycan by the NMDA receptor in the developing spinal cord

RG Kalb and S Hockfield

Section of Neuroanatomy, Yale University School of Medicine, New Haven, CT 06510.

Activation of the N-methyl-D-aspartate (NMDA) subclass of glutamate receptors is a critical step in the selection of appropriate synaptic connections in the developing visual systems of cat and frog. Activity-dependent development of mammalian motor neurons was shown to be similarly mediated by activation of the NMDA receptor. The expression of the Cat-301 proteoglycan on motor neurons was developmentally regulated and could be specifically inhibited by blockade of the NMDA receptor at the spinal segmental level. In the adult, Cat-301 immunoreactivity on motor neurons was not diminished by NMDA receptor blockade. The NMDA receptor may regulate the expression of a class of neuronal proteins (of which Cat-301 is one example) that underlie the morphological and physiological features of activity-dependent development.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Chondroitinase ABC digestion of the perineuronal net promotes functional collateral sprouting in the cuneate nucleus after cervical spinal cord injury..
J. M. Massey, C. H. Hubscher, M. R. Wagoner, J. A. Decker, J. Amps, J. Silver, and S. M. Onifer (2006)
J. Neurosci. 26, 4406-4414
   Abstract »    Full Text »    PDF »
The AMPA Receptor Subunit GluR1 Regulates Dendritic Architecture of Motor Neurons.
F. M. Inglis, R. Crockett, S. Korada, W. C. Abraham, M. Hollmann, and R. G. Kalb (2002)
J. Neurosci. 22, 8042-8051
   Abstract »    Full Text »    PDF »
Aggrecan Glycoforms Contribute to the Molecular Heterogeneity of Perineuronal Nets.
R. T. Matthews, G. M. Kelly, C. A. Zerillo, G. Gray, M. Tiemeyer, and S. Hockfield (2002)
J. Neurosci. 22, 7536-7547
   Abstract »    Full Text »    PDF »
Synaptic Control of Motoneuronal Excitability.
J. C. Rekling, G. D. Funk, D. A. Bayliss, X.-W. Dong, and J. L. Feldman (2000)
Physiol Rev 80, 767-852
   Abstract »    Full Text »    PDF »
The Role of Nitric Oxide and NMDA Receptors in the Development of Motor Neuron Dendrites.
F. M. Inglis, F. Furia, K. E. Zuckerman, S. M. Strittmatter, and R. G. Kalb (1998)
J. Neurosci. 18, 10493-10501
   Abstract »    Full Text »    PDF »
NMDA EPSCs at Glutamatergic Synapses in the Spinal Cord Dorsal Horn of the Postnatal Rat.
R. Bardoni, P. C. Magherini, and A. B. MacDermott (1998)
J. Neurosci. 18, 6558-6567
   Abstract »    Full Text »    PDF »
Patterns of Chondroitin Sulfate Immunoreactivity in the Developing Tectum Reflect Regional Differences in Glycosaminoglycan Biosynthesis.
D. Hoffman-Kim, A. D. Lander, and S. Jhaveri (1998)
J. Neurosci. 18, 5881-5890
   Abstract »    Full Text »    PDF »
REVIEW {blacksquare} : Glial Derived Extracellular Matrix Components: Important Roles in Axon Growth and Guidance.
A. Faissner (1997)
Neuroscientist 3, 371-380
   Abstract »    PDF »
Functional Respiratory Rhythm Generating Networks in Neonatal Mice Lacking NMDAR1 Gene.
G. D. Funk, S. M. Johnson, J. C. Smith, X.-W. Dong, J. Lai, and J. L. Feldman (1997)
J Neurophysiol 78, 1414-1420
   Abstract »    Full Text »    PDF »
A Family of Activity-Dependent Neuronal Cell-Surface Chondroitin Sulfate Proteoglycans in Cat Visual Cortex.
C. Lander, P. Kind, M. Maleski, and S. Hockfield (1997)
J. Neurosci. 17, 1928-1939
   Abstract »    Full Text »    PDF »
Review : Glial Boundaries and Scars: Programs for Normal Development and Wound Healing in the Brain.
L. B. Thomas and D. A. Steindler (1995)
Neuroscientist 1, 142-154
   Abstract »    PDF »
Current Excitement about the Glutamate Receptor Family.
R. G. Kalb (1995)
Neuroscientist 1, 60-63
   Abstract »    PDF »
Regulation of motor neuron dendrite growth by NMDA receptor activation.
R. Kalb (1994)
Development 120, 3063-3071
   Abstract »    PDF »
Expression of Neural Proteoglycans Correlates with the Acquisition of Mature Neuronal Properties in the Mammalian Brain.
S. Hockfield, R.G. Kalb, S. Zaremba, and H. Fryer (1990)
Cold Spring Harb Symp Quant Biol 55, 505-514
   Abstract »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)