Science 28 September 1990: Vol. 249. no. 4976, pp. 1577 - 1580 DOI: 10.1126/science.2218500

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Articles

Regulation of leukemic cell differentiation and retinoid-induced gene expression by statins.

A. Sassano, M. Lo Iacono, G. Antico, A. Jordan, S. Uddin, R. A. Calogero, and L. C. Platanias (2009)
Mol. Cancer Ther. 8, 615-625
 |  Abstract »  |  Full Text »  |  PDF »

Chromosomal translocations: revisited yet again.

J. D. Rowley (2008)
Blood 112, 2183-2189
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The promyelocytic leukemia protein functions as a negative regulator of IFN-{gamma} signaling.

Y.-H. Choi, R. Bernardi, P. P. Pandolfi, and E. N. Benveniste (2006)
PNAS 103, 18715-18720
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Retinoic acid induces leukemia cell G1 arrest and transition into differentiation by inhibiting cyclin-dependent kinase-activating kinase binding and phosphorylation of PML/RAR{alpha}.

J.-g. Wang, L. W. Barsky, E. Davicioni, K. I. Weinberg, T. J. Triche, X.-k. Zhang, and L. Wu (2006)
FASEB J 20, 2142-2144
 |  Abstract »  |  Full Text »  |  PDF »

Epigenomic Changes during Leukemia Cell Differentiation: Analysis of Histone Acetylation and Cytosine Methylation Using CpG Island Microarrays.

M. Nouzova, N. Holtan, M. M. Oshiro, R. B. Isett, J. L. Munoz-Rodriguez, A. F. List, M. L. Narro, S. J. Miller, N. C. Merchant, and B. W. Futscher (2004)
J. Pharmacol. Exp. Ther. 311, 968-981
 |  Abstract »  |  Full Text »  |  PDF »

Promyelocytic Leukemia Is a Direct Inhibitor of SAPK2/p38 Mitogen-activated Protein Kinase.

J. Shin, B. Park, S. Cho, S. Lee, Y. Kim, S.-O. Lee, K. Cho, S. Lee, B.-S. Jin, J.-H. Ahn, et al. (2004)
J. Biol. Chem. 279, 40994-41003
 |  Abstract »  |  Full Text »  |  PDF »

Inaugural Article: Biography of Zhu Chen.

D. Bradley (2004)
PNAS 101, 5325-5327
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JAML, a novel protein with characteristics of a junctional adhesion molecule, is induced during differentiation of myeloid leukemia cells.

C. Moog-Lutz, F. Cave-Riant, F. C. Guibal, M. A. Breau, Y. Di Gioia, P. O. Couraud, Y. E. Cayre, S. Bourdoulous, and P. G. Lutz (2003)
Blood 102, 3371-3378
 |  Abstract »  |  Full Text »  |  PDF »

Downstream Codons in the Retinoic Acid Receptor beta -2 and beta -4 mRNAs Initiate Translation of a Protein Isoform That Disrupts Retinoid-activated Transcription.

L. I. Chen, K. M. Sommer, and K. Swisshelm (2002)
J. Biol. Chem. 277, 35411-35421
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Clinicobiological features and outcome of acute promyelocytic leukemia occurring as a second tumor: the GIMEMA experience.

A. Pulsoni, L. Pagano, F. Lo Coco, G. Avvisati, L. Mele, E. Di Bona, R. Invernizzi, F. Leoni, F. Marmont, A. Mele, et al. (2002)
Blood 100, 1972-1976
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Mechanisms of Action of Arsenic Trioxide.

W. H. Miller Jr., H. M. Schipper, J. S. Lee, J. Singer, and S. Waxman (2002)
Cancer Res. 62, 3893-3903
 |  Abstract »  |  Full Text »  |  PDF »

Advances in the Management of Acute Promyelocytic Leukemia and Other Hematologic Malignancies with Arsenic Trioxide.

J. L. Slack, S. Waxman, G. Tricot, M. S. Tallman, and C. D. Bloomfield (2002)
Oncologist 7, 1-13
 |  Abstract »  |  Full Text »  |  PDF »

Effects of Promyelocytic Leukemia Protein on Virus-Host Balance.

W. V. Bonilla, D. D. Pinschewer, P. Klenerman, V. Rousson, M. Gaboli, P. P. Pandolfi, R. M. Zinkernagel, M. S. Salvato, and H. Hengartner (2002)
J. Virol. 76, 3810-3818
 |  Abstract »  |  Full Text »  |  PDF »

Free Radicals in the Physiological Control of Cell Function.

W. Droge (2002)
Physiol Rev 82, 47-95
 |  Abstract »  |  Full Text »  |  PDF »

Angiogenesis in acute promyelocytic leukemia: induction by vascular endothelial growth factor and inhibition by all-trans retinoic acid.

A. R. Kini, L. C. Peterson, M. S. Tallman, and M. W. Lingen (2001)
Blood 97, 3919-3924
 |  Abstract »  |  Full Text »  |  PDF »

Oncogenes and tumor suppressors in the molecular pathogenesis of acute promyelocytic leukemia.

P. P. Pandolfi (2001)
Hum. Mol. Genet. 10, 769-775
 |  Abstract »  |  Full Text »  |  PDF »

The Growth Suppressor PML Represses Transcription by Functionally and Physically Interacting with Histone Deacetylases.

W.-S. Wu, S. Vallian, E. Seto, W.-M. Yang, D. Edmondson, S. Roth, and K.-S. Chang (2001)
Mol. Cell. Biol. 21, 2259-2268
 |  Abstract »  |  Full Text »

Clinical Experience of Arsenic Trioxide in Relapsed Acute Promyelocytic Leukemia.

S. L. Soignet (2001)
Oncologist 6, 11-16
 |  Abstract »  |  Full Text »

DNA Recognition by the Aberrant Retinoic Acid Receptors Implicated in Human Acute Promyelocytic Leukemia.

H. Hauksdóttir and M. L. Privalsky (2001)
Cell Growth Differ. 12, 85-98
 |  Abstract »  |  Full Text »

Induction of Differentiation of Acute Promyelocytic Leukemia Cells by a Cytidine Deaminase-resistant Analogue of 1-{beta}-D-Arabinofuranosylcytosine, 1-(2-Deoxy-2-methylene-{beta}-D-erythro-pentofuranosyl)cytidine.

N. Niitsu, Y. Ishii, A. Matsuda, and Y. Honma (2001)
Cancer Res. 61, 178-185
 |  Abstract »  |  Full Text »

Granulocytic Differentiation of Human NB4 Promyelocytic Leukemia Cells Induced by All-trans Retinoic Acid Metabolites.

N. Idres, G. Benoît, M. A. Flexor, M. Lanotte, and G. G. Chabot (2001)
Cancer Res. 61, 700-705
 |  Abstract »  |  Full Text »

Treatment of newly diagnosed and relapsed acute promyelocytic leukemia with intravenous liposomal all-trans retinoic acid.

D. Douer, E. Estey, S. Santillana, J. M. Bennett, G. Lopez-Bernstein, K. Boehm, and T. Williams (2001)
Blood 97, 73-80
 |  Abstract »  |  Full Text »  |  PDF »

Fenretinide Therapy in Prostate Cancer: Effects on Tissue and Serum Retinoid Concentration.

C. Thaller, M. Shalev, A. Frolov, G. Eichele, T. C. Thompson, R. H. Williams, O. Dillioglugil, and D. Kadmon (2000)
J. Clin. Oncol. 18, 3804-3808
 |  Abstract »  |  Full Text »  |  PDF »

Sp110 Localizes to the PML-Sp100 Nuclear Body and May Function as a Nuclear Hormone Receptor Transcriptional Coactivator.

D. B. Bloch, A. Nakajima, T. Gulick, J.-D. Chiche, D. Orth, S. M. de la Monte, and K. D. Bloch (2000)
Mol. Cell. Biol. 20, 6138-6146
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Leukemia initiated by PMLRARalpha : the PML domain plays a critical role while retinoic acid-mediated transactivation is dispensable.

S. C. Kogan, S.-h. Hong, D. B. Shultz, M. L. Privalsky, and J. M. Bishop (2000)
Blood 95, 1541-1550
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Promyelocytic Leukemia (Pml) Nuclear Bodies Are Protein Structures That Do Not Accumulate RNA.

F.-M. Boisvert, M. J. Hendzel, and D. P. Bazett-Jones (2000)
J. Cell Biol. 148, 283-292
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Chromatin Remodeling and Leukemia: New Therapeutic Paradigms.

R. L. Redner, J. Wang, and J. M. Liu (1999)
Blood 94, 417-428
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Complete Remission of t(11;17) Positive Acute Promyelocytic Leukemia Induced by All-trans Retinoic Acid and Granulocyte Colony-Stimulating Factor.

J.H. Jansen, M.C. de Ridder, W.M.C. Geertsma, C.A.J. Erpelinck, K. van Lom, E.M.E. Smit, R. Slater, B.A. v. Reijden, G.E. de Greef, P. Sonneveld, et al. (1999)
Blood 94, 39-45
 |  Abstract »  |  Full Text »  |  PDF »

Structural and Functional Heterogeneity of Nuclear Bodies.

D. B. Bloch, J.-D. Chiche, D. Orth, S. M. de la Monte, A. Rosenzweig, and K. D. Bloch (1999)
Mol. Cell. Biol. 19, 4423-4430
 |  Abstract »  |  Full Text »  |  PDF »

Distinct leukemia phenotypes in transgenic mice and different corepressor interactions generated by promyelocytic leukemia variant fusion genes PLZF-RARalpha and NPM-RARalpha.

G.-X. Cheng, X.-H. Zhu, X.-Q. Men, L. Wang, Q.-H. Huang, X. L. Jin, S.-M. Xiong, J. Zhu, W.-M. Guo, J.-Q. Chen, et al. (1999)
PNAS 96, 6318-6323
 |  Abstract »  |  Full Text »  |  PDF »

Complete Remission after Treatment of Acute Promyelocytic Leukemia with Arsenic Trioxide.

S. L. Soignet, P. Maslak, Z.-G. Wang, S. Jhanwar, E. Calleja, L. J. Dardashti, D. Corso, A. DeBlasio, J. Gabrilove, D. A. Scheinberg, et al. (1998)
N. Engl. J. Med. 339, 1341-1348
 |  Abstract »  |  Full Text »  |  PDF »

Localization of nascent RNA and CREB binding protein with the PML-containing nuclear body.

V. J. LaMorte, J. A. Dyck, R. L. Ochs, and R. M. Evans (1998)
PNAS 95, 4991-4996
 |  Abstract »  |  Full Text »  |  PDF »

ncl-1 Is Required for the Regulation of Cell Size and Ribosomal RNA Synthesis in Caenorhabditis elegans.

D. J. Frank and M. B. Roth (1998)
J. Cell Biol. 140, 1321-1329
 |  Abstract »  |  Full Text »  |  PDF »

Role of PML in Cell Growth and the Retinoic Acid Pathway.

Z. Gang Wang, L. Delva, M. Gaboli, R. Rivi, M. Giorgio, C. Cordon-Cardo, F. Grosveld, and P. Paolo Pandolfi (1998)
Science 279, 1547-1551
 |  Abstract »  |  Full Text »

The Promyelocytic Leukemia Gene Product (PML) Forms Stable Complexes with the Retinoblastoma Protein.

M. Alcalay, L. Tomassoni, E. Colombo, S. Stoldt, F. Grignani, M. Fagioli, L. Szekely, K. Helin, and P. G. Pelicci (1998)
Mol. Cell. Biol. 18, 1084-1093
 |  Abstract »  |  Full Text »

Ret finger protein is a normal component of PML nuclear bodies and interacts directly with PML.

T Cao, E Duprez, K. Borden, P. Freemont, and L. Etkin (1998)
J. Cell Sci. 111, 1319-1329
 |  Abstract »  |  PDF »

Modulation of mRNA Expression of a Novel Human Myeloid-Selective CCAAT/Enhancer Binding Protein Gene (C/EBPepsilon ).

D. Y. Chih, A. M. Chumakov, D. J. Park, A. G. Silla, and H. P. Koeffler (1997)
Blood 90, 2987-2994
 |  Abstract »  |  Full Text »  |  PDF »

Retinoic Acid Induces Aggregation of the Acute Promyelocytic Leukemia Cell Line NB-4 by Utilization of LFA-1 and ICAM-2.

R. S. Larson, D. C. Brown, and L. A. Sklar (1997)
Blood 90, 2747-2756
 |  Abstract »  |  Full Text »  |  PDF »

Leukemia-associated retinoic acid receptor alpha  fusion partners, PML and PLZF, heterodimerize and colocalize to nuclear bodies.

M. H. M. Koken, A. Reid, F. Quignon, M. K. Chelbi-Alix, J. M. Davies, J. H. S. Kabarowski, J. Zhu, S. Dong, S.-J. Chen, Z. Chen, et al. (1997)
PNAS 94, 10255-10260
 |  Abstract »  |  Full Text »  |  PDF »

SMRT corepressor interacts with PLZF and with the PML-retinoic acid receptor alpha  (RARalpha ) and PLZF-RARalpha oncoproteins associated with acute promyelocytic leukemia.

S.-H. Hong, G. David, C.-W. Wong, A. Dejean, and M. L. Privalsky (1997)
PNAS 94, 9028-9033
 |  Abstract »  |  Full Text »  |  PDF »

Acute leukemia with promyelocytic features in PML/RARalpha  transgenic mice.

L.-Z. He, C. Tribioli, R. Rivi, D. Peruzzi, P. G. Pelicci, V. Soares, G. Cattoretti, and P. P. Pandolfi (1997)
PNAS 94, 5302-5307
 |  Abstract »  |  Full Text »  |  PDF »

Stat1 Is Induced and Activated by All-Trans Retinoic Acid in Acute Promyelocytic Leukemia Cells.

M. Gianni, M. Terao, I. Fortino, M. LiCalzi, V. Viggiano, T. Barbui, A. Rambaldi, and E. Garattini (1997)
Blood 89, 1001-1012
 |  Abstract »  |  Full Text »  |  PDF »

Identification and Characterization of a Leukocyte-specific Component of the Nuclear Body.

D. B. Bloch, S. M. de la Monte, P. Guigaouri, A. Filippov, and K. D. Bloch (1996)
J. Biol. Chem. 271, 29198-29204
 |  Abstract »  |  Full Text »  |  PDF »

All-Trans-Retinoic Acid Pharmacology and Its Impact on the Treatment of Acute Promyelocytic Leukemia.

P. C. Adamson (1996)
Oncologist 1, 305-314
 |  Abstract »  |  Full Text »  |  PDF »

Analysis of the Growth and Transformation Suppressor Domains of Promyelocytic Leukemia Gene, PML.

X.-F. Le, P. Yang, and K.-S. Chang (1996)
J. Biol. Chem. 271, 130-135
 |  Abstract »  |  Full Text »  |  PDF »

Self-fusion of the ALL 1 Gene: A New Genetic Mechanism for Acute Leukemia.

S. A. Schichman, E. Canaani, and C. M. Croce (1995)
JAMA 273, 571-576
 |  Abstract »  |  PDF »

Lymphohematopoietic progenitors immortalized by a retroviral vector harboring a dominant-negative retinoic acid receptor can recapitulate lymphoid, myeloid, and erythroid development..

S Tsai, S Bartelmez, E Sitnicka, and S Collins (1994)
Genes & Dev. 8, 2831-2841
 |  Abstract »  |  PDF »

Fusion between transcription factor CBF beta/PEBP2 beta and a myosin heavy chain in acute myeloid leukemia.

P Liu, S. Tarle, A Hajra, D. Claxton, P Marlton, M Freedman, M. Siciliano, and F. Collins (1993)
Science 261, 1041-1044
 |  Abstract »  |  PDF »

Acute Promyelocytic Leukemia.

R. P. Warrell, H. de The, Z.-Y. Wang, and L. Degos (1993)
N. Engl. J. Med. 329, 177-189
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A mutated retinoic acid receptor-alpha exhibiting dominant-negative activity alters the lineage development of a multipotent hematopoietic cell line..

S Tsai, S Bartelmez, R Heyman, K Damm, R Evans, and S J Collins (1992)
Genes & Dev. 6, 2258-2269
 |  Abstract »  |  PDF »

Autocrine Secretion--10 Years Later.

M. B. Sporn and A. B. Roberts (1992)
Ann Intern Med 117, 408-414
 |  Abstract »  |  PDF »

The "Retinoic Acid Syndrome" in Acute Promyelocytic Leukemia.

S. R. Frankel, A. Eardley, G. Lauwers, M. Weiss, and R. P. Warrell Jr. (1992)
Ann Intern Med 117, 292-296
 |  Abstract »  |  PDF »

Characterization of a zinc finger gene disrupted by the t(15;17) in acute promyelocytic leukemia.

A. Goddard, J Borrow, P. Freemont, and E Solomon (1991)
Science 254, 1371-1374
 |  Abstract »  |  PDF »

Chromosome aberrations and cancer.

E Solomon, J Borrow, and A. Goddard (1991)
Science 254, 1153-1160
 |  Abstract »  |  PDF »

RET Finger Protein Is a Transcriptional Repressor and Interacts with Enhancer of Polycomb That Has Dual Transcriptional Functions.

Y. Shimono, H. Murakami, Y. Hasegawa, and M. Takahashi (2000)
J. Biol. Chem. 275, 39411-39419
 |  Abstract »  |  Full Text »  |  PDF »

PRAM-1 Is a Novel Adaptor Protein Regulated by Retinoic Acid (RA) and Promyelocytic Leukemia (PML)-RA Receptor alpha in Acute Promyelocytic Leukemia Cells.

C. Moog-Lutz, E. J. Peterson, P. G. Lutz, S. Eliason, F. Cave-Riant, A. Singer, Y. Di Gioia, S. Dmowski, J. Kamens, Y. E. Cayre, et al. (2001)
J. Biol. Chem. 276, 22375-22381
 |  Abstract »  |  Full Text »  |  PDF »

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