Science 21 September 1990: Vol. 249. no. 4975, pp. 1433 - 1436 DOI: 10.1126/science.2205920

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Identification of IL-17-producing FOXP3+ regulatory T cells in humans.

K. S. Voo, Y.-H. Wang, F. R. Santori, C. Boggiano, Y.-H. Wang, K. Arima, L. Bover, S. Hanabuchi, J. Khalili, E. Marinova, et al. (2009)
PNAS 106, 4793-4798
 |  Abstract »  |  Full Text »  |  PDF »

Suppression of Autoimmune Diabetes by Soluble Galectin-1.

M. J. Perone, S. Bertera, W. J. Shufesky, S. J. Divito, A. Montecalvo, A. R. Mathers, A. T. Larregina, M. Pang, N. Seth, K. W. Wucherpfennig, et al. (2009)
J. Immunol. 182, 2641-2653
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Dipeptidyl Peptidase IV Inhibition With MK0431 Improves Islet Graft Survival in Diabetic NOD Mice Partially via T-Cell Modulation.

S.-J. Kim, C. Nian, D. J. Doudet, and C. H.S. McIntosh (2009)
Diabetes 58, 641-651
 |  Abstract »  |  Full Text »  |  PDF »

All-trans Retinoic Acid Inhibits Type 1 Diabetes by T Regulatory (Treg)-Dependent Suppression of Interferon-{gamma}-Producing T-cells Without Affecting Th17 Cells.

Y.-H. Van, W.-H. Lee, S. Ortiz, M.-H. Lee, H.-J. Qin, and C.-P. Liu (2009)
Diabetes 58, 146-155
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Expression of the retinoblastoma protein RbAp48 in exocrine glands leads to Sjogren's syndrome-like autoimmune exocrinopathy.

N. Ishimaru, R. Arakaki, S. Yoshida, A. Yamada, S. Noji, and Y. Hayashi (2008)
J. Exp. Med. 205, 2915-2927
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On the Pathogenicity of Autoantigen-Specific T-Cell Receptors.

A. R. Burton, E. Vincent, P. Y. Arnold, G. P. Lennon, M. Smeltzer, C.-S. Li, K. Haskins, J. Hutton, R. M. Tisch, E. E. Sercarz, et al. (2008)
Diabetes 57, 1321-1330
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Recruitment and Activation of Macrophages by Pathogenic CD4 T Cells in Type 1 Diabetes: Evidence for Involvement of CCR8 and CCL1.

J. Cantor and K. Haskins (2007)
J. Immunol. 179, 5760-5767
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Cytopiloyne, a Polyacetylenic Glucoside, Prevents Type 1 Diabetes in Nonobese Diabetic Mice.

C. L.-T. Chang, S.-L. Chang, Y.-M. Lee, Y.-M. Chiang, D.-Y. Chuang, H.-K. Kuo, and W.-C. Yang (2007)
J. Immunol. 178, 6984-6993
 |  Abstract »  |  Full Text »  |  PDF »

Modulatory Role of DR4- to DQ8-restricted CD4 T-Cell Responses and Type 1 Diabetes Susceptibility.

X. Ge, J. D. Piganelli, H. M. Tse, S. Bertera, C. E. Mathews, M. Trucco, L. Wen, and W. A. Rudert (2006)
Diabetes 55, 3455-3462
 |  Abstract »  |  Full Text »  |  PDF »

Cyclophosphamide-Induced Type-1 Diabetes in the NOD Mouse Is Associated with a Reduction of CD4+CD25+Foxp3+ Regulatory T Cells.

S. Brode, T. Raine, P. Zaccone, and A. Cooke (2006)
J. Immunol. 177, 6603-6612
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Dendritic Cells Expressing Transgenic Galectin-1 Delay Onset of Autoimmune Diabetes in Mice.

M. J. Perone, S. Bertera, Z. S. Tawadrous, W. J. Shufesky, J. D. Piganelli, L. G. Baum, M. Trucco, and A. E. Morelli (2006)
J. Immunol. 177, 5278-5289
 |  Abstract »  |  Full Text »  |  PDF »

T cells to a dominant epitope of GAD65 express a public CDR3 motif.

A. Quinn, M. McInerney, D. Huffman, B. McInerney, S. Mayo, K. Haskins, and E. Sercarz (2006)
Int. Immunol. 18, 967-979
 |  Abstract »  |  Full Text »  |  PDF »

Regulatory T Cells Can Mediate Their Function through the Stimulation of APCs to Produce Immunosuppressive Nitric Oxide.

C. Chen, W.-h. Lee, L. Zhong, and C.-P. Liu (2006)
J. Immunol. 176, 3449-3460
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An Animal Model of Autoimmune Emphysema.

L. Taraseviciene-Stewart, R. Scerbavicius, K.-H. Choe, M. Moore, A. Sullivan, M. R. Nicolls, A. P. Fontenot, R. M. Tuder, and N. F. Voelkel (2005)
Am. J. Respir. Crit. Care Med. 171, 734-742
 |  Abstract »  |  Full Text »  |  PDF »

Different Diabetogenic Potential of Autoaggressive CD8+ Clones Associated with IFN-{gamma}-Inducible Protein 10 (CXC Chemokine Ligand 10) Production but Not Cytokine Expression, Cytolytic Activity, or Homing Characteristics.

M. Ejrnaes, N. Videbaek, U. Christen, A. Cooke, B. K. Michelsen, and M. von Herrath (2005)
J. Immunol. 174, 2746-2755
 |  Abstract »  |  Full Text »  |  PDF »

Peptides From Common Viral and Bacterial Pathogens Can Efficiently Activate Diabetogenic T-Cells.

V. A. Judkowski, G. M. Allicotti, N. Sarvetnick, and C. Pinilla (2004)
Diabetes 53, 2301-2309
 |  Abstract »  |  Full Text »  |  PDF »

T-Cell Receptor Transgenic Response to an Endogenous Polymorphic Autoantigen Determines Susceptibility to Diabetes.

M. E. Pauza, C. M. Dobbs, J. He, T. Patterson, S. Wagner, B. S. Anobile, B. J. Bradley, D. Lo, and K. Haskins (2004)
Diabetes 53, 978-988
 |  Abstract »  |  Full Text »  |  PDF »

Terminal Deoxynucleotidyltransferase Deficiency Decreases Autoimmune Disease in Diabetes-Prone Nonobese Diabetic Mice and Lupus-Prone MRL-Faslpr Mice.

I. F. Robey, M. Peterson, M. S. Horwitz, D. H. Kono, T. Stratmann, A. N. Theofilopoulos, N. Sarvetnick, L. Teyton, and A. J. Feeney (2004)
J. Immunol. 172, 4624-4629
 |  Abstract »  |  Full Text »  |  PDF »

Systemic Administration of IL-18 Promotes Diabetes Development in Young Nonobese Diabetic Mice.

Y. Oikawa, A. Shimada, A. Kasuga, J. Morimoto, T. Osaki, H. Tahara, T. Miyazaki, F. Tashiro, E. Yamato, J.-i. Miyazaki, et al. (2003)
J. Immunol. 171, 5865-5875
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Peptide-MHC Class II Dimers as Therapeutics to Modulate Antigen-Specific T Cell Responses in Autoimmune Diabetes.

E. L. Masteller, M. R. Warner, W. Ferlin, V. Judkowski, D. Wilson, N. Glaichenhaus, and J. A. Bluestone (2003)
J. Immunol. 171, 5587-5595
 |  Abstract »  |  Full Text »  |  PDF »

Ex Vivo Analysis of Thymic CD4 T Cells in Nonobese Diabetic Mice with Tetramers Generated from I-Ag7/Class II-Associated Invariant Chain Peptide Precursors.

M.-H. Jang, N. P. Seth, and K. W. Wucherpfennig (2003)
J. Immunol. 171, 4175-4186
 |  Abstract »  |  Full Text »  |  PDF »

Prevention of Diabetes in NOD Mice by Administration of Dendritic Cells Deficient in Nuclear Transcription Factor-{kappa}B Activity.

L. Ma, S. Qian, X. Liang, L. Wang, J. E. Woodward, N. Giannoukakis, P. D. Robbins, S. Bertera, M. Trucco, J. J. Fung, et al. (2003)
Diabetes 52, 1976-1985
 |  Abstract »  |  Full Text »  |  PDF »

Induction of Autoantigen-Specific Th2 and Tr1 Regulatory T Cells and Modulation of Autoimmune Diabetes.

C. Chen, W.-H. Lee, P. Yun, P. Snow, and C.-P. Liu (2003)
J. Immunol. 171, 733-744
 |  Abstract »  |  Full Text »  |  PDF »

Detection and Characterization of T Cells Specific for BDC2.5 T Cell-Stimulating Peptides.

S. You, C. Chen, W.-H. Lee, C.-H. Wu, V. Judkowski, C. Pinilla, D. B. Wilson, and C.-P. Liu (2003)
J. Immunol. 170, 4011-4020
 |  Abstract »  |  Full Text »  |  PDF »

Evidence for shared recognition of a peptide ligand by a diverse panel of non-obese diabetic mice-derived, islet-specific, diabetogenic T cell clones.

K. Yoshida, T. Martin, K. Yamamoto, C. Dobbs, C. Munz, N. Kamikawaji, N. Nakano, H.-G. Rammensee, T. Sasazuki, K. Haskins, et al. (2002)
Int. Immunol. 14, 1439-1447
 |  Abstract »  |  Full Text »  |  PDF »

Increased Nonobese Diabetic Th1:Th2 (IFN-{gamma}:IL-4) Ratio Is CD4+ T Cell Intrinsic and Independent of APC Genetic Background.

S. Koarada, Y. Wu, G. Olshansky, and W. M. Ridgway (2002)
J. Immunol. 169, 6580-6587
 |  Abstract »  |  Full Text »  |  PDF »

T Cell Response to Preproinsulin I and II in the Nonobese Diabetic Mouse.

P. Halbout, J.-P. Briand, C. Becourt, S. Muller, and C. Boitard (2002)
J. Immunol. 169, 2436-2443
 |  Abstract »  |  Full Text »  |  PDF »

CD4+ T Cells from Glutamic Acid Decarboxylase (GAD)65-specific T Cell Receptor Transgenic Mice Are Not Diabetogenic and Can Delay Diabetes Transfer.

K. V. Tarbell, M. Lee, E. Ranheim, C. C. Chao, M. Sanna, S.-K. Kim, P. Dickie, L. Teyton, M. Davis, and H. McDevitt (2002)
J. Exp. Med. 196, 481-492
 |  Abstract »  |  Full Text »  |  PDF »

Molecular Mechanisms for Gender Differences in Susceptibility to T Cell-Mediated Autoimmune Diabetes in Nonobese Diabetic Mice.

M. Bao, Y. Yang, H.-S. Jun, and J.-W. Yoon (2002)
J. Immunol. 168, 5369-5375
 |  Abstract »  |  Full Text »  |  PDF »

Human DQ8 Can Substitute for Murine I-Ag7 in the Selection of Diabetogenic T Cells Restricted to I-Ag71.

L. Wen, F. S. Wong, R. Sherwin, and C. Mora (2002)
J. Immunol. 168, 3635-3640
 |  Abstract »  |  Full Text »  |  PDF »

Expression of CD40 identifies a unique pathogenic T cell population in type 1 diabetes.

D. H. Wagner Jr., G. Vaitaitis, R. Sanderson, M. Poulin, C. Dobbs, and K. Haskins (2002)
PNAS 99, 3782-3787
 |  Abstract »  |  Full Text »  |  PDF »

A Metalloporphyrin-Based Superoxide Dismutase Mimic Inhibits Adoptive Transfer of Autoimmune Diabetes by a Diabetogenic T-Cell Clone.

J. D. Piganelli, S. C. Flores, C. Cruz, J. Koepp, I. Batinic-Haberle, J. Crapo, B. Day, R. Kachadourian, R. Young, B. Bradley, et al. (2002)
Diabetes 51, 347-355
 |  Abstract »  |  Full Text »  |  PDF »

Cutting Edge: Interactions Through the IL-10 Receptor Regulate Autoimmune Diabetes.

J. M. Phillips, N. M. Parish, M. Drage, and A. Cooke (2001)
J. Immunol. 167, 6087-6091
 |  Abstract »  |  Full Text »  |  PDF »

Increased Entry into the IFN-{gamma} Effector Pathway by CD4+ T Cells Selected by I-Ag7 on a Nonobese Diabetic Versus C57BL/6 Genetic Background.

S. Koarada, Y. Wu, and W. M. Ridgway (2001)
J. Immunol. 167, 1693-1702
 |  Abstract »  |  Full Text »  |  PDF »

Expression of the Chemokines MIP-1{{alpha}}, MCP-1, and RANTES in Experimental Autoimmune Uveitis.

I. J. Crane, S. McKillop-Smith, C. A. Wallace, G. R. Lamont, and J. V. Forrester (2001)
Invest. Ophthalmol. Vis. Sci. 42, 1547-1552
 |  Abstract »  |  Full Text »

Comparison of a T Cell Clone and of T Cells from a TCR Transgenic Mouse: TCR Transgenic T Cells Specific for Self-Antigen Are Atypical.

C. M. Dobbs and K. Haskins (2001)
J. Immunol. 166, 2495-2504
 |  Abstract »  |  Full Text »  |  PDF »

Low Dose Streptozotocin-Induced Diabetes in Rat Insulin Promoter-mCD80-Transgenic Mice Is T Cell Autoantigen-Specific and CD28 Dependent.

K. Pechhold, N. B. Patterson, C. Blum, C. L. Fleischacker, B. O. Boehm, and D. M. Harlan (2001)
J. Immunol. 166, 2531-2539
 |  Abstract »  |  Full Text »  |  PDF »

Identification of MHC Class II-Restricted Peptide Ligands, Including a Glutamic Acid Decarboxylase 65 Sequence, that Stimulate Diabetogenic T Cells from Transgenic BDC2.5 Nonobese Diabetic Mice.

V. Judkowski, C. Pinilla, K. Schroder, L. Tucker, N. Sarvetnick, and D. B. Wilson (2001)
J. Immunol. 166, 908-917
 |  Abstract »  |  Full Text »  |  PDF »

A Self MHC Class II {beta}-Chain Peptide Prevents Diabetes in Nonobese Diabetic Mice.

P. Chaturvedi, B. Agrawal, M. Zechel, E. Lee-Chan, and B. Singh (2000)
J. Immunol. 164, 6610-6620
 |  Abstract »  |  Full Text »  |  PDF »

Induction of Diabetes in Nonobese Diabetic Mice by Th2 T Cell Clones from a TCR Transgenic Mouse.

M. Poulin and K. Haskins (2000)
J. Immunol. 164, 3072-3078
 |  Abstract »  |  Full Text »  |  PDF »

Vitamin D and Autoimmunity: Is Vitamin D Status an Environmental Factor Affecting Autoimmune Disease Prevalence?.

M. T. Cantorna (2000)
Experimental Biology and Medicine 223, 230-233
 |  Abstract »  |  Full Text »

Prevalent CD8+ T cell response against one peptide/MHC complex in autoimmune diabetes.

B. Anderson, B.-J. Park, J. Verdaguer, A. Amrani, and P. Santamaria (1999)
PNAS 96, 9311-9316
 |  Abstract »  |  Full Text »  |  PDF »

I-Ag7-Mediated Antigen Presentation by B Lymphocytes Is Critical in Overcoming a Checkpoint in T Cell Tolerance to Islet {beta} Cells of Nonobese Diabetic Mice.

H. Noorchashm, Y. K. Lieu, N. Noorchashm, S. Y. Rostami, S. A. S. Greeley, A. Schlachterman, H. K. Song, L. E. Noto, A. M. Jevnikar, C. F. Barker, et al. (1999)
J. Immunol. 163, 743-750
 |  Abstract »  |  Full Text »  |  PDF »

In Autoimmune Diabetes the Transition from Benign to Pernicious Insulitis Requires an Islet Cell Response to Tumor Necrosis Factor {alpha}.

S. V. Pakala, M. Chivetta, C. B. Kelly, and J. D. Katz (1999)
J. Exp. Med. 189, 1053-1062
 |  Abstract »  |  Full Text »  |  PDF »

The Role of Macrophages in T Cell-mediated Autoimmune Diabetes in Nonobese Diabetic Mice.

H.-S. Jun, C.-S. Yoon, L. Zbytnuik, N. van Rooijen, and J.-W. Yoon (1999)
J. Exp. Med. 189, 347-358
 |  Abstract »  |  Full Text »  |  PDF »

Initiation of Autoimmune Diabetes by Developmentally Regulated Presentation of Islet Cell Antigens in the Pancreatic Lymph Nodes.

P. Hoglund, J. Mintern, C. Waltzinger, W. Heath, C. Benoist, and D. Mathis (1999)
J. Exp. Med. 189, 331-339
 |  Abstract »  |  Full Text »  |  PDF »

Overexpression of Natural Killer T Cells Protects V{alpha}14-J{alpha}281 Transgenic Nonobese Diabetic Mice against Diabetes.

A. Lehuen, O. Lantz, L. Beaudoin, V. Laloux, C. Carnaud, A. Bendelac, J.-F. Bach, and R. C. Monteiro (1998)
J. Exp. Med. 188, 1831-1839
 |  Abstract »  |  Full Text »  |  PDF »

The Inability of the Nonobese Diabetic Class II Molecule to Form Stable Peptide Complexes Does Not Reflect a Failure to Interact Productively with DM.

M. Peterson and A. J. Sant (1998)
J. Immunol. 161, 2961-2967
 |  Abstract »  |  Full Text »  |  PDF »

Cytotoxic T Lymphocyte-associated Antigen 4 (CTLA-4) Regulates the Unfolding of Autoimmune Diabetes.

F. Luhder, P. Hoglund, J. P. Allison, C. Benoist, and D. Mathis (1998)
J. Exp. Med. 187, 427-432
 |  Abstract »  |  Full Text »  |  PDF »

Major Histocompatibility Complex Class II Molecules Can Protect from Diabetes by Positively Selecting T Cells with Additional Specificities.

F. Luhder, J. Katz, C. Benoist, and D. Mathis (1998)
J. Exp. Med. 187, 379-387
 |  Abstract »  |  Full Text »  |  PDF »

Spontaneous Autoimmune Diabetes in Monoclonal T Cell Nonobese Diabetic Mice.

J. Verdaguer, D. Schmidt, A. Amrani, B. Anderson, N. Averill, and P. Santamaria (1997)
J. Exp. Med. 186, 1663-1676
 |  Abstract »  |  Full Text »  |  PDF »

Major Histocompatibility Complex-linked Control of Autoimmunity.

L. S. Wicker (1997)
J. Exp. Med. 186, 973-975
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Requirement of Fas for the Development of Autoimmune Diabetes in Nonobese Diabetic Mice.

N. Itoh, A. Imagawa, T. Hanafusa, M. Waguri, K. Yamamoto, H. Iwahashi, M. Moriwaki, H. Nakajima, J. Miyagawa, M. Namba, et al. (1997)
J. Exp. Med. 186, 613-618
 |  Abstract »  |  Full Text »  |  PDF »

beta cell apoptosis in T cell-mediated autoimmune diabetes.

M. O. Kurrer, S. V. Pakala, H. L. Hanson, and J. D. Katz (1997)
PNAS 94, 213-218
 |  Abstract »  |  Full Text »  |  PDF »

T helper cell subsets in insulin-dependent diabetes.

J. Katz, C Benoist, and D Mathis (1995)
Science 268, 1185-1188
 |  Abstract »  |  PDF »

T cell receptor specificity and diabetes in nonobese diabetic mice.

D Mathis and C Benoist (1993)
Science 262, 1583
 |  PDF »

Immunologic Aspects of Endocrine Diseases.

J. R. Baker Jr (1992)
JAMA 268, 2899-2903
 |  Abstract »  |  PDF »

Pinpointing when T cell costimulatory receptor CTLA-4 must be engaged to dampen diabetogenic T cells.

F. Luhder, C. Chambers, J. P. Allison, C. Benoist, and D. Mathis (2000)
PNAS 97, 12204-12209
 |  Abstract »  |  Full Text »  |  PDF »

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