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Science 24 August 1990:
Vol. 249. no. 4971, pp. 918 - 921
DOI: 10.1126/science.2392683
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Articles
Science, Vol 249, Issue 4971, 918-921
Copyright © 1990 by American Association for the Advancement of Science
Presentation of exogenous antigen with class I major histocompatibility complex molecules
KL Rock,
S Gamble,
and
L Rothstein
Department of Pathology, Harvard Medical School, Boston, MA 02115.
Soluble antigens (Ags) in the extracellular fluids are excluded from the class I major histocompatibility complex (MHC)-restricted pathway of Ag presentation in most cells. However, an exogenous Ag can be internalized, processed, and presented in association with class I MHC molecules on specialized Ag-presenting cells (APCs). These APCs express class II molecules and can simultaneously present exogenous Ags to both class I and class II MHC-restricted T cells. These APCs may be important participants in the regulation of host immune responses. This APC activity may explain several phenomena of cytotoxic T lymphocyte (CTL) priming in vivo and might be exploited for eliciting CTL responses to protein vaccines.
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