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Science 3 August 1990:
Vol. 249. no. 4968, pp. 556 - 560
DOI: 10.1126/science.2166337

Articles

Science, Vol 249, Issue 4968, 556-560
Copyright © 1990 by American Association for the Advancement of Science


articles

A family of AMPA-selective glutamate receptors

K Keinanen, W Wisden, B Sommer, P Werner, A Herb, TA Verdoorn, B Sakmann, and PH Seeburg

Laboratory of Molecular Neuroendocrinology, University of Heidelberg, F.R.G.

Four cloned cDNAs encoding 900-amino acid putative glutamate receptors with approximately 70 percent sequence identity were isolated from a rat brain cDNA library. In situ hybridization revealed differential expression patterns of the cognate mRNAs throughout the brain. Functional expression of the cDNAs in cultured mammalian cells generated receptors displaying alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA)-selective binding pharmacology (AMPA = quisqualate greater than glutamate greater than kainate) as well as cation channels gated by glutamate, AMPA, and kainate and blocked by 6,7-dinitroquinoxaline-2,3-dione (CNQX).


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A. L. Carvalho, K. Kameyama, and R. L. Huganir (1999)
J. Neurosci. 19, 4748-4754
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Subtype-specific Assembly of alpha -Amino-3-hydroxy-5-methyl-4-isoxazole Propionic Acid Receptor Subunits Is Mediated by Their N-terminal Domains.
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Mice with Genetically Modified NMDA and AMPA Receptors.
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Functional and Immunocytochemical Identification of Glutamate Autoreceptors of an NMDA Type in Crayfish Neuromuscular Junction.
N. Feinstein, D. Parnas, H. Parnas, J. Dudel, and I. Parnas (1998)
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K. Kask, D. Zamanillo, A. Rozov, N. Burnashev, R. Sprengel, and P. H. Seeburg (1998)
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J. Neurosci. 18, 6723-6739
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Dendrodendritic Inhibition in the Olfactory Bulb Is Driven by NMDA Receptors.
N. E. Schoppa, J. M. Kinzie, Y. Sahara, T. P. Segerson, and G. L. Westbrook (1998)
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E. M. Aronica, J. A. Gorter, S. Grooms, J. A. Kessler, M. V. L. Bennett, R. S. Zukin, and D. M. Rosenbaum (1998)
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M. A. Varney, S. P. Rao, C. Jachec, C. Deal, S. D. Hess, L. P. Daggett, F.-F. Lin, E. C. Johnson, and G. Veliçelebi (1998)
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D. W. Brann and V. B. Mahesh (1997)
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R. J. O'Brien, A. L. Mammen, S. Blackshaw, M. D. Ehlers, J. D. Rothstein, and R. L. Huganir (1997)
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J. Biol. Chem. 272, 11295-11301
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Activation and Desensitization of Hippocampal Kainate Receptors.
T. J. Wilding and J. E. Huettner (1997)
J. Neurosci. 17, 2713-2721
   Abstract »    Full Text »    PDF »
AMPA and NMDA Glutamate Receptor Subunits in Midbrain Dopaminergic Neurons in the Squirrel Monkey: An Immunohistochemical and In Situ Hybridization Study.
M. Paquet, M. Tremblay, J.-J. Soghomonian, and Y. Smith (1997)
J. Neurosci. 17, 1377-1396
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Differential Surface Expression and Phosphorylation of the N-Methyl-D-aspartate Receptor Subunits NR1 and NR2 in Cultured Hippocampal Neurons.
R. A. Hall and T. R. Soderling (1997)
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An Alanine Residue in the M3-M4 Linker Lines the Glycine Binding Pocket of the N-Methyl-D-aspartate Receptor.
M. W. Wood, H. M.A. VanDongen, and A. M.J. VanDongen (1997)
J. Biol. Chem. 272, 3532-3537
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Cellular, Subcellular, and Subsynaptic Distribution of AMPA-Type Glutamate Receptor Subunits in the Neostriatum of the Rat.
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J. Neurosci. 17, 819-833
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AMPA-Preferring Receptors Mediate Excitatory Synaptic Inputs to Retinal Ganglion Cells.
P. D. Lukasiewicz, J. A. Wilson, and J. E. Lawrence (1997)
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AMPA Receptor Flip/Flop Mutants Affecting Deactivation, Desensitization, and Modulation by Cyclothiazide, Aniracetam, and Thiocyanate.
K. M. Partin, M. W. Fleck, and M. L. Mayer (1996)
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J. H. Morrison, S. J. Siegel, A. H. Gazzaley, and G. W. Huntley (1996)
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Organization of AMPA Receptor Subunits at a Glutamate Synapse: A Quantitative Immunogold Analysis of Hair Cell Synapses in the Rat Organ of Corti.
A. Matsubara, J. H. Laake, S. Davanger, S.-i. Usami, and O. P. Ottersen (1996)
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The Responsiveness of a Tetracycline-sensitive Expression System Differs in Different Cell Lines.
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Gene Structure of the Murine N-Methyl D-Aspartate Receptor Subunit NR2C.
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