Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Site Tools

  • AAAS
  • Subscribe
  • Feedback

Site Search

Search Advanced

Science 27 July 1990:
Vol. 249. no. 4967, pp. 414 - 417
DOI: 10.1126/science.1696029
Prev | Table of Contents | Next

Articles

Science, Vol 249, Issue 4967, 414-417
Copyright © 1990 by American Association for the Advancement of Science

articles

Prevention of activated neutrophil adhesion to endothelium by soluble adhesion protein GMP140

Gamble JR, MP Skinner, MC Berndt, and MA Vadas

Division of Human Immunology, Institute of Medical and Veterinary Science, Adelaide, South Australia.

Neutrophils and monocytes, but not lymphocytes, adhered strongly to plastic surfaces coated with GMP140, a protein of endothelial cells and platelets. This adhesion of neutrophils was mediated by GMP140 and not by the CD18 integrin complex. By contrast, GMP140 in solution inhibited the CD18-dependent adhesion of tumor necrosis factor-alpha-activated neutrophils to plastic surfaces and resting endothelium, but not of resting neutrophils to tumor necrosis factor-alpha-activated endothelium. Thus, the binding of a soluble form of an adhesion protein selectively inhibited another set of adhesive events. Soluble GMP140 may be important in maintaining the nonadhesiveness of neutrophils in the circulation and may serve to limit inflammatory reactions.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Raised Plasma Soluble P-Selectin in Peripheral Arterial Occlusive Disease Enhances Leukocyte Adhesion.
K.J. Woollard, D. Kling, S. Kulkarni, A.M. Dart, S. Jackson, and J. Chin-Dusting (2006)
Circ. Res. 98, 149-156
   Abstract »    Full Text »    PDF »
Potential role for mast cell tryptase in recruitment of inflammatory cells to endothelium.
M. C. Meyer, M. H. Creer, and J. McHowat (2005)
Am J Physiol Cell Physiol 289, C1485-C1491
   Abstract »    Full Text »    PDF »
Rolling of Th1 Cells via P-Selectin Glycoprotein Ligand-1 Stimulates LFA-1-Mediated Cell Binding to ICAM-1.
K. Atarashi, T. Hirata, M. Matsumoto, N. Kanemitsu, and M. Miyasaka (2005)
J. Immunol. 174, 1424-1432
   Abstract »    Full Text »    PDF »
Expanding Role of Circulating Adhesion Molecules in Assessing Prognosis and Treatment Response in Human Immunodeficiency Virus Infection.
N. V. Sipsas and P. P. Sfikakis (2004)
Clin. Vaccine Immunol. 11, 996-1001
   Full Text »    PDF »
The Effects of Standard Anthracycline-Based Chemotherapy on Soluble ICAM-1 and Vascular Endothelial Growth Factor Levels in Breast Cancer.
P. J. Mills, B. Parker, V. Jones, K. A. Adler, C. J. Perez, S. Johnson, M. Cohen-Zion, M. Marler, G. R. Sadler, J. E. Dimsdale, et al. (2004)
Clin. Cancer Res. 10, 4998-5003
   Abstract »    Full Text »    PDF »
Adhesion to E-selectin promotes growth inhibition and apoptosis of human and murine hematopoietic progenitor cells independent of PSGL-1.
I. G. Winkler, K. R. Snapp, P. J. Simmons, and J.-P. Levesque (2004)
Blood 103, 1685-1692
   Abstract »    Full Text »    PDF »
Independent Pathways of P-Selectin and Complement-Mediated Renal Ischemia/Reperfusion Injury.
C. A. Farrar, Y. Wang, S. H. Sacks, and W. Zhou (2004)
Am. J. Pathol. 164, 133-141
   Abstract »    Full Text »    PDF »
The adhesion molecule P-selectin and cardiovascular disease.
A. D. Blann, S. K. Nadar, and G. Y.H. Lip (2003)
Eur. Heart J. 24, 2166-2179
   Abstract »    Full Text »    PDF »
Hypoxia reduces CD80 expression on monocytes but enhances their LPS-stimulated TNF-{alpha} secretion.
N. Lahat, M. A. Rahat, M. Ballan, L. Weiss-Cerem, M. Engelmayer, and H. Bitterman (2003)
J. Leukoc. Biol. 74, 197-205
   Abstract »    Full Text »    PDF »
Hypercholesterolemia Promotes P-Selectin-Dependent Platelet-Endothelial Cell Adhesion in Postcapillary Venules.
A. Tailor and D. N. Granger (2003)
Arterioscler. Thromb. Vasc. Biol. 23, 675-680
   Abstract »    Full Text »    PDF »
Blockade of p38{alpha} MAPK Ameliorates Acute Inflammatory Renal Injury in Rat Anti-GBM Glomerulonephritis.
C. Stambe, R. C. Atkins, G. H. Tesch, A. M. Kapoun, P. A. Hill, G. F. Schreiner, and D. J. Nikolic-Paterson (2003)
J. Am. Soc. Nephrol. 14, 338-351
   Abstract »    Full Text »    PDF »
Elevated levels of circulating CD44 in patients with systemic sclerosis: association with a milder subset.
K. Komura, S. Sato, M. Fujimoto, M. Hasegawa, and K. Takehara (2002)
Rheumatology 41, 1149-1154
   Abstract »    Full Text »    PDF »
Inflammation, Cell Adhesion Molecules, and Stroke: Tools in Pathophysiology and Epidemiology?.
A. D. Blann, P. M. Ridker, and G. Y.H. Lip (2002)
Stroke 33, 2141-2143
   Full Text »    PDF »
Human platelets express heat shock protein receptors and regulate dendritic cell maturation.
N. Hilf, H. Singh-Jasuja, P. Schwarzmaier, C. Gouttefangeas, H.-G. Rammensee, and H. Schild (2002)
Blood 99, 3676-3682
   Abstract »    Full Text »    PDF »
Endothelial Cell Adhesion Molecules and Cardiopulmonary Bypass.
M. P Vallely, P. G Bannon, C. F Hughes, and L. Kritharides (2001)
Asian Cardiovasc Thorac Ann 9, 349-355
   Abstract »    Full Text »    PDF »
Association Between P-Selectin Gene Polymorphisms and Soluble P-Selectin Levels and Their Relation to Coronary Artery Disease.
S. C. Barbaux, S. Blankenberg, H. J. Rupprecht, C. Francomme, C. Bickel, G. Hafner, V. Nicaud, J. Meyer, F. Cambien, and L. Tiret (2001)
Arterioscler. Thromb. Vasc. Biol. 21, 1668-1673
   Abstract »    Full Text »    PDF »
Newly recognized cellular abnormalities in the gray platelet syndrome.
A. Drouin, R. Favier, J.-M. Masse, N. Debili, A. Schmitt, C. Elbim, J. Guichard, M. Adam, M.-A. Gougerot-Pocidalo, and E. M. Cramer (2001)
Blood 98, 1382-1391
   Abstract »    Full Text »    PDF »
Continuous perfusion of pulmonary arteries during total cardiopulmonary bypass favorably affects levels of circulating adhesion molecules and lung function.
T. Suzuki, T. Ito, I. Kashima, K. Teruya, and T. Fukuda (2001)
J. Thorac. Cardiovasc. Surg. 122, 242-248
   Abstract »    Full Text »    PDF »
Risk stratification in unstable angina and non-Q wave myocardial infarction using soluble cell adhesion molecules.
N T Mulvihill, J B Foley, R T Murphy, R Curtin, P A Crean, and M Walsh (2001)
Heart 85, 623-627
   Abstract »    Full Text »
Platelet-Leukocyte Cross Talk in Whole Blood.
N. Li, H. Hu, M. Lindqvist, E. Wikstrom-Jonsson, A. H. Goodall, and P. Hjemdahl (2000)
Arterioscler. Thromb. Vasc. Biol. 20, 2702-2708
   Abstract »    Full Text »    PDF »
P-Selectin Expression on Platelets Determines Size and Stability of Platelet Aggregates.
M. Merten and P. Thiagarajan (2000)
Circulation 102, 1931-1936
   Abstract »    Full Text »    PDF »
Evidence of prolonged inflammation in unstable angina and non-Q wave myocardial infarction.
N. T. Mulvihill, J. B. Foley, R. Murphy, P. Crean, and M. Walsh (2000)
J. Am. Coll. Cardiol. 36, 1210-1216
   Abstract »    Full Text »    PDF »
Primary Structure and Functional Characterization of a Soluble, Alternatively Spliced Form of B7-1.
S. J. Faas, M. A. Giannoni, A. P. Mickle, C. L. Kiesecker, D. J. Reed, D. Wu, W. L. Fodor, J. P. Mueller, L. A. Matis, and R. P. Rother (2000)
J. Immunol. 164, 6340-6348
   Abstract »    Full Text »    PDF »
Editorial: Cell Adhesion Molecules in Cardiovascular Disease and Its Risk Factors--What Can Soluble Levels Tell Us?.
A. D. Blann and G. Y. H. Lip (2000)
J. Clin. Endocrinol. Metab. 85, 1745-1747
   Full Text »
Soluble P-Selectin in Human Plasma: Effect of Anticoagulant Matrix and its Levels in Patients With Cardiovascular Disorders.
H. M. Amin, S. Ahmad, J. M. Walenga, D. A. Hoppensteadt, H. Leitz, and J. Fareed (2000)
Clinical and Applied Thrombosis/Hemostasis 6, 71-76
   Abstract »    PDF »
P-Selectin Binding Promotes the Adhesion of Monocytes to VCAM-1 Under Flow Conditions.
T. Yago, M. Tsukuda, and M. Minami (1999)
J. Immunol. 163, 367-373
   Abstract »    Full Text »    PDF »
Adhesive Interaction Between P-Selectin and Sialyl Lewisx Plays an Important Role in Recurrent Coronary Arterial Thrombosis in Dogs.
H. Ikeda, T. Ueyama, T. Murohara, H. Yasukawa, N. Haramaki, H. Eguchi, A. Katoh, Y. Takajo, I. Onitsuka, T. Ueno, et al. (1999)
Arterioscler. Thromb. Vasc. Biol. 19, 1083-1090
   Abstract »    Full Text »    PDF »
Homocysteine Enhances Neutrophil-Endothelial Interactions in Both Cultured Human Cells and Rats In Vivo.
N. P. B. Dudman, S. E. Temple, X. W. Guo, W. Fu, and M. A. Perry (1999)
Circ. Res. 84, 409-416
   Abstract »    Full Text »    PDF »
Cell adhesion molecules in cardiovascular disease: what can soluble levels tell us?.
A. D BLANN and G. Y H LIP (1999)
Heart 81, 101-102
   Full Text »
P-Selectin and Platelet Clearance.
G. Berger, D. W. Hartwell, and D. D. Wagner (1998)
Blood 92, 4446-4452
   Abstract »    Full Text »    PDF »
Role of P-Selectin Cytoplasmic Domain in Granular Targeting In Vivo and in Early Inflammatory Responses.
D. W. Hartwell, T. N. Mayadas, G. Berger, P. S. Frenette, H. Rayburn, R. O. Hynes, and D. D. Wagner (1998)
J. Cell Biol. 143, 1129-1141
   Abstract »    Full Text »    PDF »
Plasma Soluble P-Selectin in Acute Myocardial Infarction: Effects of Coronary Recanalization Therapy.
N. Aoki and H. Tomoda (1998)
Angiology 49, 807-813
   Abstract »    PDF »
Studies of Multimerin in Human Endothelial Cells.
C. P. M. Hayward, E. M. Cramer, Z. Song, S. Zheng, R. Fung, J.-M. Masse, R. H. Stead, and T. J. Podor (1998)
Blood 91, 1304-1317
   Abstract »    Full Text »    PDF »
Studies of a Second Family With the Quebec Platelet Disorder: Evidence That the Degradation of the alpha -Granule Membrane and Its Soluble Contents Are Not Secondary to a Defect in Targeting Proteins to alpha -Granules.
C. P.M. Hayward, E. M. Cramer, W. H. Kane, S. Zheng, M. Bouchard, J.-M. Masse, and G. E. Rivard (1997)
Blood 89, 1243-1253
   Abstract »    Full Text »    PDF »
A Tissue Plasminogen Activator/P-Selectin Fusion Protein Is an Effective Thrombolytic Agent.
K. Fujise, B. M. Revelle, L. Stacy, E. L. Madison, E. T.H. Yeh, J. T. Willerson, and P. J. Beck (1997)
Circulation 95, 715-722
   Abstract »    Full Text »
Treatment of Focal Cerebral Ischemia With Synthetic Oligopeptide Corresponding to Lectin Domain of Selectin.
E. Morikawa, S.-M. Zhang, Y. Seko, T. Toyoda, and T. Kirino (1996)
Stroke 27, 951-956
   Abstract »    Full Text »
Influence of Temperature on Neutrophil Trafficking During Clinical Cardiopulmonary Bypass.
P. Menasche, J. Peynet, N. Haeffner-Cavaillon, M.-P. Carreno, T. de Chaumaray, V. Dillisse, B. Faris, A. Piwnica, G. Bloch, and A. Tedgui (1995)
Circulation 92, 334-340
   Abstract »    Full Text »
Increased Soluble Form of P-Selectin in Patients With Unstable Angina.
H. Ikeda, Y. Takajo, K. Ichiki, T. Ueno, S. Maki, T. Noda, K. Sugi, and T. Imaizumi (1995)
Circulation 92, 1693-1696
   Abstract »    Full Text »
Pro-coagulant state resulting from high levels of soluble P-selectin in blood.
P. Andre, D. Hartwell, I. Hrachovinova, S. Saffaripour, and D. D. Wagner (2000)
PNAS 97, 13835-13840
   Abstract »    Full Text »    PDF »


ADVERTISEMENT
Click Me!

ADVERTISEMENT
Click Me!

To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)