Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Science 20 July 1990:
Vol. 249. no. 4966, pp. 283 - 287
DOI: 10.1126/science.1695760
Prev | Table of Contents | Next

Articles

Science, Vol 249, Issue 4966, 283-287
Copyright © 1990 by American Association for the Advancement of Science

articles

Characterization of naturally occurring minor histocompatibility peptides including H-4 and H-Y

O Rotzschke, K Falk, HJ Wallny, S Faath, and HG Rammensee

Max-Planck-Institut fur Biologie, Abteilung Immungenetik, Tubingen, Federal Republic of Germany.

Minor histocompatibility (H) antigens can be peptides derived from cellular proteins that are presented on the cell surface by major histocompatibility complex (MHC) class I molecules. This is similar to viral antigens, because in both cases cytotoxic T lymphocytes (CTLs) recognize artificially produced peptides loaded on target cells. Naturally processed minor H peptides were found to be similar to those artificial CTL-epitopes, as far as size and hydrophobicity is concerned. The peptides studied were isolated from a transfectant that expressed a model CTL-defined antigen, beta-galactosidase, from male cells that express H-Y, which has been known operationally since 1955, and from cells that express H-4, known since 1961.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
To each (MHC molecule) its own (binding motif)..
L. A. Sherman (2006)
J. Immunol. 177, 2739-2740
   Full Text »    PDF »
Induction of BCR-ABL-specific immunity following vaccination with chaperone-rich cell lysates derived from BCR-ABL+ tumor cells.
Y. Zeng, M. W. Graner, S. Thompson, M. Marron, and E. Katsanis (2005)
Blood 105, 2016-2022
   Abstract »    Full Text »    PDF »
Duration of Alloantigen Presentation and Avidity of T Cell Antigen Recognition Correlate with Immunodominance of CTL Response to Minor Histocompatibility Antigens.
Y. Yoshimura, R. Yadav, G. J. Christianson, W. U. Ajayi, D. C. Roopenian, and S. Joyce (2004)
J. Immunol. 172, 6666-6674
   Abstract »    Full Text »    PDF »
The H4b Minor Histocompatibility Antigen Is Caused by a Combination of Genetically Determined and Posttranslational Modifications.
R. Yadav, Y. Yoshimura, A. Boesteanu, G. J. Christianson, W. U. Ajayi, R. Shashidharamurthy, A. K. Stanic, D. C. Roopenian, and S. Joyce (2003)
J. Immunol. 170, 5133-5142
   Abstract »    Full Text »    PDF »
Cutting Edge: The Minor Histocompatibility Antigen H60 Peptide Interacts with Both H-2Kb and NKG2D.
A. Cerwenka, C. A. O'Callaghan, J. A. Hamerman, R. Yadav, W. Ajayi, D. C. Roopenian, S. Joyce, and L. L. Lanier (2002)
J. Immunol. 168, 3131-3134
   Abstract »    Full Text »    PDF »
In APCs, the Autologous Peptides Selected by the Diabetogenic I-Ag7 Molecule Are Unique and Determined by the Amino Acid Changes in the P9 Pocket.
A. Suri, I. Vidavsky, K. van der Drift, O. Kanagawa, M. L. Gross, and E. R. Unanue (2002)
J. Immunol. 168, 1235-1243
   Abstract »    Full Text »    PDF »
Cytotoxic T Lymphocyte Epitopes of HIV-1 Nef: Generation of Multiple Definitive Major Histocompatibility Complex Class I Ligands by Proteasomes.
M. Lucchiari-Hartz, P. M. van Endert, G. Lauvau, R. Maier, A. Meyerhans, D. Mann, K. Eichmann, and G. Niedermann (2000)
J. Exp. Med. 191, 239-252
   Abstract »    Full Text »    PDF »
Intracellular Rate-Limiting Steps in MHC Class I Antigen Processing.
M. Montoya and M. Del Val (1999)
J. Immunol. 163, 1914-1922
   Abstract »    Full Text »    PDF »
The Molecular and Functional Characterization of a Dominant Minor H Antigen, H60.
S. Malarkannan, P. P. Shih, P. A. Eden, T. Horng, A. R. Zuberi, G. Christianson, D. Roopenian, and N. Shastri (1998)
J. Immunol. 161, 3501-3509
   Abstract »    Full Text »    PDF »
Control of Murine Cytomegalovirus in the Lungs: Relative but Not Absolute Immunodominance of the Immediate-Early 1 Nonapeptide during the Antiviral Cytolytic T-Lymphocyte Response in Pulmonary Infiltrates.
R. Holtappels, J. Podlech, G. Geginat, H.-P. Steffens, D. Thomas, and M. J. Reddehase (1998)
J. Virol. 72, 7201-7212
   Abstract »    Full Text »    PDF »
T Cells Specific for a Polymorphic Segment of CD45 Induce Graft-Versus-Host Disease with Predominant Pulmonary Vasculitis.
W. Chen, G. S. Chatta, W. D. Rubin, J. G. Clark, R. C. Hackman, D. K. Madtes, D. H. Ligitt, Y. Kusunoki, P. J. Martin, and M. A. Cheever (1998)
J. Immunol. 161, 909-918
   Abstract »    Full Text »    PDF »
Human H-Y: a male-specific histocompatibility antigen derived from the SMCY protein.
W Wang, L. Meadows, J. den Haan, N. Sherman, Y Chen, E Blokland, J Shabanowitz, A. Agulnik, R. Hendrickson, C. Bishop, et al. (1995)
Science 269, 1588-1590
   Abstract »    PDF »
Identification of a graft versus host disease-associated human minor histocompatibility antigen.
J. den Haan, N. Sherman, E Blokland, E Huczko, F Koning, J. Drijfhout, J Skipper, J Shabanowitz, D. Hunt, V. Engelhard, et al. (1995)
Science 268, 1476-1480
   Abstract »    PDF »
Thermal stability comparison of purified empty and peptide-filled forms of a class I MHC molecule.
M. Fahnestock, I Tamir, L Narhi, and P. Bjorkman (1992)
Science 258, 1658-1662
   Abstract »    PDF »
HLA-A2.1-associated peptides from a mutant cell line: a second pathway of antigen presentation.
R. Henderson, H Michel, K Sakaguchi, J Shabanowitz, E Appella, D. Hunt, and V. Engelhard (1992)
Science 255, 1264-1266
   Abstract »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)