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ArticlesCopyright © 1990 by American Association for the Advancement of Science
Activation of polyphosphoinositide hydrolysis in T cells by H-2 alloantigen but not MLS determinants
Division of Membrane Biology, Medical Biology Institute, La Jolla, CA 92037.
Murine minor lymphocyte-stimulating (Mls) determinants are cell surface antigens that stimulate strong primary T cell responses; the responding T cells display restricted T cell receptor (TCR) V beta gene usage. Interaction of T cells with mitogens or major histocompatibility complex (MHC) antigens activated the polyphosphoinositide (PI) signaling pathway, but this pathway was not triggered by Mls recognition. However, interleukin-2 (IL-2) secretion and proliferation to all three stimuli were comparable. Thus, although recognition of both allo-H-2 and Mls determinants is thought to be mediated by the TCR, these antigens appear to elicit biochemically distinct signal transduction pathways.
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Science. ISSN 0036-8075 (print), 1095-9203 (online)
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