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Science 22 June 1990:
Vol. 248. no. 4962, pp. 1550 - 1553
DOI: 10.1126/science.2193400
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Articles

Science, Vol 248, Issue 4962, 1550-1553
Copyright © 1990 by American Association for the Advancement of Science

articles

An RNA polymerase II transcription factor shares functional properties with Escherichia coli sigma 70

JW Conaway and RC Conaway

Program in Molecular and Cell Biology, Oklahoma Medical Research Foundation, Oklahoma City 73104.

A mammalian transcription factor, which, along with other factors, is essential for accurate initiation of transcription from promoters by RNA polymerase II, has been found to regulate the interaction of polymerase and DNA. This factor, designated beta gamma, drastically reduces the affinity of RNA polymerase II for free DNA containing either promoter or nonpromoter sequences. In this respect, beta gamma functions as does the bacterial transcription initiation factor sigma 70, which expedites the binding of Escherichia coli RNA polymerase to promoters in part by accelerating dissociation of the polymerase from nonpromoter sites in DNA.


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Structure and Function of the Small Subunit of TFIIF (RAP30) from Drosophilamelanogaster.
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Functional analysis of Drosophila transcription factor IIB..
S L Wampler and J T Kadonaga (1992)
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HIV-1 Tat acts as a processivity factor in vitro in conjunction with cellular elongation factors..
H Kato, H Sumimoto, P Pognonec, C H Chen, C A Rosen, and R G Roeder (1992)
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Sigma factor relatives in eukaryotes.
J. Jaehning (1991)
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