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Science 15 June 1990:
Vol. 248. no. 4961, pp. 1419 - 1421
DOI: 10.1126/science.2356470
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Articles

Science, Vol 248, Issue 4961, 1419-1421
Copyright © 1990 by American Association for the Advancement of Science

articles

Flunarizine protects neurons from death after axotomy or NGF deprivation

KM Rich and JP Hollowell

Department of Neurosurgery, Washington University School of Medicine, St. Louis, Mo 63110.

Systemically administered flunarizine enhanced neuronal survival in lumbar sensory ganglia in newborn rats after axotomy. Flunarizine-treated rats lost 71 percent fewer neurons than the untreated control rats at the end of 1 week. In cell culture, flunarizine at 30 to 40 microM also prevented neuronal death in nerve growth factor-dependent embryonic sensory and sympathetic neurons after the abrupt withdrawal of neurotrophic support. The drug may cause this effect by acting at an intracellular site, one distinct from its blockade of voltage-dependent calcium channels.


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Differential Inhibition of T-Type Calcium Channels by Neuroleptics.
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