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Science 15 June 1990:
Vol. 248. no. 4961, pp. 1416 - 1419
DOI: 10.1126/science.2162561
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Articles
Science, Vol 248, Issue 4961, 1416-1419
Copyright © 1990 by American Association for the Advancement of Science
Cell cycle dependence of chloride permeability in normal and cystic fibrosis lymphocytes
JK Bubien,
KL Kirk,
TA Rado,
and
RA Frizzell
Department of Physiology and Biophysics, University of Alabama, Birmingham 35294.
Cystic fibrosis (CF) is a genetic disease characterized by abnormal regulation of epithelial cell chloride channels. Nonepithelial cells, including lymphocytes and fibroblasts, may exhibit a similar defect. Two independent techniques were used to assess the macroscopic chloride permeability (PCl) of freshly isolated B lymphocytes and of B and T lymphocyte cell lines. Values for PCl increased specifically during the G1 phase of the cell cycle and could be further enhanced by increasing intracellular adenosine 3',5'-monophosphate (cAMP) or calcium. In lymphocytes from CF patients, regulation of PCl during the cell cycle and by second messengers was absent. Characterization of the cell cycle-dependent expression of the chloride permeability defect in lymphocytes from CF patients increases the utility of these cells in the analysis of the functional consequences of mutations in the CF gene.
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