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Science 11 May 1990:
Vol. 248. no. 4956, pp. 745 - 748
DOI: 10.1126/science.2110384
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Articles

Science, Vol 248, Issue 4956, 745-748
Copyright © 1990 by American Association for the Advancement of Science

articles

Protease nexin-II (amyloid beta-protein precursor): a platelet alpha-granule protein

WE Van Nostrand, AH Schmaier, JS Farrow, and DD Cunningham

Department of Microbiology and Molecular Genetics, University of California, Irvine 92717.

Protease nexin-II (PN-II) [amyloid beta-protein precursor (APP)] and the amyloid beta-protein are major constituents of neuritic plaques and cerebrovascular deposits in individuals with Alzheimer's disease and Down syndrome. Both the brain and the circulation have been implicated as sources of these molecules, although they have not been detected in blood. Human platelets have now been found to contain relatively large amounts of PN-II/APP. Platelet PN-II/APP was localized in platelet alpha-granules and was secreted upon platelet activation. Because PN-II/APP is a potent protease inhibitor and possesses growth factor activity, these results implicate PN-II/APP in wound repair. In certain disease states, alterations in platelet release and processing and clearance of PN-II/APP and its derived fragments could lead to pathological accumulation of these proteins.


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