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Science 11 May 1990:
Vol. 248. no. 4956, pp. 732 - 735
DOI: 10.1126/science.2139735
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Articles

Science, Vol 248, Issue 4956, 732-735
Copyright © 1990 by American Association for the Advancement of Science

articles

Organization of the human and mouse low-affinity Fc gamma R genes: duplication and recombination

WQ Qiu, D de Bruin, BH Brownstein, R Pearse, and JV Ravetch

Division of Molecular Biology, Sloan-Kettering Institute, New York, NY 10021.

Receptors for immunoglobulin G immune complexes (Fc gamma RII and Fc gamma RIII) are expressed on most hematopoietic cells and show much structural and functional diversity. In order to determine the genetic basis for this diversity, a family of genes encoding the human and mouse receptors was isolated and characterized. Humans have five distinct genes for low-affinity Fc gamma Rs, in contrast to two in the mouse. With the use of yeast artificial chromosomes, the genes encoding the human receptors were oriented and linked, which established the structure of this complex locus. Comparison of the human and mouse genes generated a model for the evolutionary amplification of this locus.


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