Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Science 4 May 1990:
Vol. 248. no. 4955, pp. 605 - 607
DOI: 10.1126/science.2159184
Prev | Table of Contents | Next

Articles

Science, Vol 248, Issue 4955, 605-607
Copyright © 1990 by American Association for the Advancement of Science

articles

Identity of inositol 1,2-cyclic phosphate 2-phosphohydrolase with lipocortin III

TS Ross, JF Tait, and PW Majerus

Department of Internal Medicine, Washington University School of Medicine, St Louis, MO 63110.

The amino acid sequences of three fragments of cyanogen bromide-digested human placental inositol 1,2-cyclic phosphate 2-phosphohydrolase, an enzyme of the phosphatidylinositol signaling pathway, are identical to sequences within lipocortin III, a member of a family of homologous calcium- and phospholipid-binding proteins that do not have defined physiological functions. Lipocortin III has also been previously identified as placental anticoagulant protein III (PAP III) and calcimedin 35 alpha. Antibodies to PAP III detected PAP III and inositol 1,2-cyclic phosphate 2-phosphohydrolase with identical reactivity on immunoblotting. In addition, inositol 1,2-cyclic phosphate 2-phosphohydrolase was stimulated by the same acidic phospholipids that bind lipocortins.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Cloning and Characterization of the Arabidopsis Cyclic Phosphodiesterase Which Hydrolyzes ADP-ribose 1",2"-Cyclic Phosphate and Nucleoside 2',3'-Cyclic Phosphates.
P. Genschik, J. Hall, and W. Filipowicz (1997)
J. Biol. Chem. 272, 13211-13219
   Abstract »    Full Text »    PDF »
Can Enzymatic Activity, or Otherwise, Be Inferred from Structural Studies of Annexin III?.
B. Perron, A. Lewit-Bentley, B. Geny, and F. Russo-Marie (1997)
J. Biol. Chem. 272, 11321-11326
   Abstract »    Full Text »    PDF »
Dissociation of Cyclic Inositol Phosphohydrolase Activity from Annexin III.
M. C. Sekar, V. Sambandam, W. E. Grizzle, and J. M. McDonald (1996)
J. Biol. Chem. 271, 8295-8299
   Abstract »    Full Text »    PDF »
Characterization of Carbohydrate-binding Protein p33/41.
K. Kojima, K. Yamamoto, T. Irimura, T. Osawa, H. Ogawa, and I. Matsumoto (1996)
J. Biol. Chem. 271, 7679-7685
   Abstract »    Full Text »    PDF »
Expression and localization of annexin VII (synexin) in muscle cells.
S Selbert, P Fischer, D Pongratz, M Stewart, and A. Noegel (1995)
J. Cell Sci. 108, 85-95
   Abstract »    PDF »
The annexins and exocytosis.
C. Creutz (1992)
Science 258, 924-931
   Abstract »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)