Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.
Science Careers Booklet

Site Tools

  • AAAS
  • Subscribe
  • Feedback

Site Search

Search Advanced

Science 6 April 1990:
Vol. 248. no. 4951, pp. 76 - 79
DOI: 10.1126/science.2157286
Prev | Table of Contents | Next

Articles

Science, Vol 248, Issue 4951, 76-79
Copyright © 1990 by American Association for the Advancement of Science

articles

Association of human papillomavirus types 16 and 18 E6 proteins with p53

BA Werness, AJ Levine, and PM Howley

Laboratory of Tumor Virus Biology, National Cancer Institute, Bethesda, MD 20892.

Human papillomavirus type 16 (HPV-16) is a DNA tumor virus that is associated with human anogenital cancers and encodes two transforming proteins, E6 and E7. The E7 protein has been shown to bind to the retinoblastoma tumor suppressor gene product, pRB. This study shows that the E6 protein of HPV-16 is capable of binding to the cellular p53 protein. The ability of the E6 proteins from different human papillomaviruses to form complexes with p53 was assayed and found to correlate with the in vivo clinical behavior and the in vitro transforming activity of these different papillomaviruses. The wild-type p53 protein has tumor suppressor properties and has also been found in association with large T antigen and the E1B 55-kilodalton protein in cells transformed by SV40 and by adenovirus type 5, respectively, providing further evidence that the human papillomaviruses, the adenoviruses, and SV40 may effect similar cellular pathways in transformation.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Human Papillomavirus Type 16 E7 Oncoprotein Associates with E2F6.
M. E. McLaughlin-Drubin, K.-W. Huh, and K. Munger (2008)
J. Virol. 82, 8695-8705
   Abstract »    Full Text »    PDF »
Role of Activating Transcription Factor 3 on TAp73 Stability and Apoptosis in Paclitaxel-Treated Cervical Cancer Cells.
Y. K. Oh, H. J. Lee, M.-H. Jeong, M. Rhee, J.-W. Mo, E. H. Song, J.-Y. Lim, K.-H. Choi, I. Jo, S. I. Park, et al. (2008)
Mol. Cancer Res. 6, 1232-1249
   Abstract »    Full Text »    PDF »
Eps8 decreases chemosensitivity and affects survival of cervical cancer patients.
Y.-J. Chen, M.-R. Shen, Y.-J. Chen, M.-C. Maa, and T.-H. Leu (2008)
Mol. Cancer Ther. 7, 1376-1385
   Abstract »    Full Text »    PDF »
p53 Loss Synergizes with Estrogen and Papillomaviral Oncogenes to Induce Cervical and Breast Cancers.
A. Shai, H. C. Pitot, and P. F. Lambert (2008)
Cancer Res. 68, 2622-2631
   Abstract »    Full Text »    PDF »
A balance between NF-Y and p53 governs the pro- and anti-apoptotic transcriptional response.
P. Benatti, V. Basile, D. Merico, L. I. Fantoni, E. Tagliafico, and C. Imbriano (2008)
Nucleic Acids Res. 36, 1415-1428
   Abstract »    Full Text »    PDF »
E3 ubiquitin ligase E6AP-mediated TSC2 turnover in the presence and absence of HPV16 E6..
L. Zheng, H. Ding, Z. Lu, Y. Li, Y. Pan, T. Ning, and Y. Ke (2008)
Genes Cells 13, 285-294
   Abstract »    Full Text »    PDF »
The SV40 Large T Antigen-p53 Complexes Bind and Activate the Insulin-like Growth Factor-I Promoter Stimulating Cell Growth.
M. Bocchetta, S. Eliasz, M. A. De Marco, J. Rudzinski, L. Zhang, and M. Carbone (2008)
Cancer Res. 68, 1022-1029
   Abstract »    Full Text »    PDF »
Role of Rb-Dependent and Rb-Independent Functions of Papillomavirus E7 Oncogene in Head and Neck Cancer.
K. Strati and P. F. Lambert (2007)
Cancer Res. 67, 11585-11593
   Abstract »    Full Text »    PDF »
Human papillomaviruses activate caspases upon epithelial differentiation to induce viral genome amplification.
C. A. Moody, A. Fradet-Turcotte, J. Archambault, and L. A. Laimins (2007)
PNAS 104, 19541-19546
   Abstract »    Full Text »    PDF »
p53 and hTERT Determine Sensitivity to Viral Apoptosis.
M. L. Nguyen, R. M. Kraft, M. Aubert, E. Goodwin, D. DiMaio, and J. A. Blaho (2007)
J. Virol. 81, 12985-12995
   Abstract »    Full Text »    PDF »
Human Papillomavirus E6 Proteins Mediate Resistance to Interferon-Induced Growth Arrest through Inhibition of p53 Acetylation.
C. Hebner, M. Beglin, and L. A. Laimins (2007)
J. Virol. 81, 12740-12747
   Abstract »    Full Text »    PDF »
Myc and Human Papillomavirus Type 16 E7 Genes Cooperate To Immortalize Human Keratinocytes.
X. Liu, G. L. Disbrow, H. Yuan, V. Tomaic, and R. Schlegel (2007)
J. Virol. 81, 12689-12695
   Abstract »    Full Text »    PDF »
Overexpression of Human Papillomavirus Type 16 Oncoproteins Enhances Hypoxia-Inducible Factor 1{alpha} Protein Accumulation and Vascular Endothelial Growth Factor Expression in Human Cervical Carcinoma Cells.
X. Tang, Q. Zhang, J. Nishitani, J. Brown, S. Shi, and A. D. Le (2007)
Clin. Cancer Res. 13, 2568-2576
   Abstract »    Full Text »    PDF »
Cyclooxygenase-2 Transcription Is Regulated by Human Papillomavirus 16 E6 and E7 Oncoproteins: Evidence of a Corepressor/Coactivator Exchange.
K. Subbaramaiah and A. J. Dannenberg (2007)
Cancer Res. 67, 3976-3985
   Abstract »    Full Text »    PDF »
The Epidemiology and Risk Factors of Head and Neck Cancer: a Focus on Human Papillomavirus.
C.C.R. Ragin, F. Modugno, and S.M. Gollin (2007)
J. Dent. Res. 86, 104-114
   Abstract »    Full Text »    PDF »
Narrative review: protein degradation and human diseases: the ubiquitin connection..
E. Reinstein and A. Ciechanover (2006)
Ann Intern Med 145, 676-684
   Abstract »    Full Text »    PDF »
Human papillomaviruses target the double-stranded RNA protein kinase pathway..
C. M. Hebner, R. Wilson, J. Rader, M. Bidder, and L. A. Laimins (2006)
J. Gen. Virol. 87, 3183-3193
   Abstract »    Full Text »    PDF »
Identification of biomarkers that distinguish human papillomavirus (HPV)-positive versus HPV-negative head and neck cancers in a mouse model.
K. Strati, H. C. Pitot, and P. F. Lambert (2006)
PNAS 103, 14152-14157
   Abstract »    Full Text »    PDF »
Transcriptome profiling the gills of amoebic gill disease (AGD)-affected Atlantic salmon (Salmo salar L.): a role for tumor suppressor p53 in AGD pathogenesis?.
R. N. Morrison, G. A. Cooper, B. F. Koop, M. L. Rise, A. R. Bridle, M. B. Adams, and B. F. Nowak (2006)
Physiol Genomics 26, 15-34
   Abstract »    Full Text »    PDF »
Potential Role for p53 in the Permissive Life Cycle of Human Cytomegalovirus..
N. C. Casavant, M. H. Luo, K. Rosenke, T. Winegardner, A. Zurawska, and E. A. Fortunato (2006)
J. Virol. 80, 8390-8401
   Abstract »    Full Text »    PDF »
Progress in Chemoprevention Drug Development: The Promise of Molecular Biomarkers for Prevention of Intraepithelial Neoplasia and Cancer--A Plan to Move Forward.
G. J. Kelloff, S. M. Lippman, A. J. Dannenberg, C. C. Sigman, H. L. Pearce, B. J. Reid, E. Szabo, V. C. Jordan, M. R. Spitz, G. B. Mills, et al. (2006)
Clin. Cancer Res. 12, 3661-3697
   Abstract »    Full Text »    PDF »
CANCER STEM CELLS: Redefining the Paradigm of Cancer Treatment Strategies.
M. Dean (2006)
Mol. Interv. 6, 140-148
   Abstract »    Full Text »    PDF »
Enhancement of the radiosensitivity of cervical cancer cells by overexpressing p73{alpha}.
S. S. Liu, K. Y.-K. Chan, R. C.-Y. Leung, H. K.-W. Law, T.-W. Leung, and H. Y.-S. Ngan (2006)
Mol. Cancer Ther. 5, 1209-1215
   Abstract »    Full Text »    PDF »
Recalcitrant verrucous lesion: verrucous hyperplasia or epithelioma cuniculatum (verrucous carcinoma)..
S. S. Kelishadi, G. A. Wirth, and G. R. D. Evans (2006)
J Am Podiatr Med Assoc 96, 148-153
   Abstract »    Full Text »    PDF »
Immortalized keratinocyte lines derived from human embryonic stem cells.
S. Iuchi, S. Dabelsteen, K. Easley, J. G. Rheinwald, and H. Green (2006)
PNAS 103, 1792-1797
   Abstract »    Full Text »    PDF »
DNA Damage Promotes Histone Deacetylase 4 Nuclear Localization and Repression of G2/M Promoters, via p53 C-terminal Lysines.
V. Basile, R. Mantovani, and C. Imbriano (2006)
J. Biol. Chem. 281, 2347-2357
   Abstract »    Full Text »    PDF »
Enhanced antiproliferative effects of alkoxyalkyl esters of cidofovir in human cervical cancer cells in vitro.
K. Y. Hostetler, S. Rought, K. A. Aldern, J. Trahan, J. R. Beadle, and J. Corbeil (2006)
Mol. Cancer Ther. 5, 156-159
   Abstract »    Full Text »    PDF »
Decreased Migration of Langerhans Precursor-Like Cells in Response to Human Keratinocytes Expressing Human Papillomavirus Type 16 E6/E7 Is Related to Reduced Macrophage Inflammatory Protein-3{alpha} Production.
J. C. Guess and D. J. McCance (2005)
J. Virol. 79, 14852-14862
   Abstract »    Full Text »    PDF »
Infection of Human Papillomavirus Type 18 and p53 Codon 72 Polymorphism in Lung Cancer Patients From India.
N. Jain, V. Singh, S. Hedau, S. Kumar, M. K. Daga, R. Dewan, N. S. Murthy, S. A. Husain, and B. C. Das (2005)
Chest 128, 3999-4007
   Abstract »    Full Text »    PDF »
Induction of Aromatase Expression in Cervical Carcinomas: Effects of Endogenous Estrogen on Cervical Cancer Cell Proliferation.
H. B. Nair, R. Luthra, N. Kirma, Y.-G. Liu, L. Flowers, D. Evans, and R. R. Tekmal (2005)
Cancer Res. 65, 11164-11173
   Abstract »    Full Text »    PDF »
Nucleo-cytoplasmic Shuttling of High Risk Human Papillomavirus E2 Proteins Induces Apoptosis.
S. Blachon, S. Bellanger, C. Demeret, and F. Thierry (2005)
J. Biol. Chem. 280, 36088-36098
   Abstract »    Full Text »    PDF »
Differential splicing of E6 within human papillomavirus type 18 variants and functional consequences.
E. De la Cruz-Hernandez, A. Garcia-Carranca, A. Mohar-Betancourt, A. Duenas-Gonzalez, A. Contreras-Paredes, E. Perez-Cardenas, R. Herrera-Goepfert, and M. Lizano-Soberon (2005)
J. Gen. Virol. 86, 2459-2468
   Abstract »    Full Text »    PDF »
Down-Regulation of p53 by Double-Stranded RNA Modulates the Antiviral Response.
J. T. Marques, D. Rebouillat, C. V. Ramana, J. Murakami, J. E. Hill, A. Gudkov, R. H. Silverman, G. R. Stark, and B. R. G. Williams (2005)
J. Virol. 79, 11105-11114
   Abstract »    Full Text »    PDF »
Association of Tumor Necrosis Factor a-2 and a-8 Microsatellite Alleles with Human Papillomavirus and Squamous Intraepithelial Lesions among Women in Brazil.
R. T. Simoes, M. A. G. Goncalves, E. A. Donadi, A. L. Simoes, J. S. R. Bettini, G. Duarte, S. M. Quintana, M. W. P. Carvalho, and E. G. Soares (2005)
J. Clin. Microbiol. 43, 3932-3937
   Abstract »    Full Text »    PDF »
Correlation of Human Papillomavirus Type 16 and Human Papillomavirus Type 18 E7 Messenger RNA Levels with Degree of Cervical Dysplasia.
M. E. Scheurer, G. Tortolero-Luna, M. Guillaud, M. Follen, Z. Chen, L. M. Dillon, and K. Adler-Storthz (2005)
Cancer Epidemiol. Biomarkers Prev. 14, 1948-1952
   Abstract »    Full Text »    PDF »
The Ubiquitin-Proteasome Pathway and Its Role in Cancer.
A. Mani and E. P. Gelmann (2005)
J. Clin. Oncol. 23, 4776-4789
   Abstract »    Full Text »    PDF »
Involvement of Nuclear Export in Human Papillomavirus Type 18 E6-Mediated Ubiquitination and Degradation of p53.
D. Stewart, A. Ghosh, and G. Matlashewski (2005)
J. Virol. 79, 8773-8783
   Abstract »    Full Text »    PDF »
Role of the E1{wedge}E4 Protein in the Differentiation-Dependent Life Cycle of Human Papillomavirus Type 31.
R. Wilson, F. Fehrmann, and L. A. Laimins (2005)
J. Virol. 79, 6732-6740
   Abstract »    Full Text »    PDF »
Differences in Smad4 Expression in Human Papillomavirus Type 16-Positive and Human Papillomavirus Type 16-Negative Head and Neck Squamous Cell Carcinoma.
A. Baez, A. Cantor, S. Fonseca, M. Marcos-Martinez, L. A. Mathews, C. A. Muro-Cacho, and T. Munoz-Antonia (2005)
Clin. Cancer Res. 11, 3191-3197
   Abstract »    Full Text »    PDF »
Immunohistochemical Expression of p16INK4a and bcl-2 According to HPV Type and to the Progression of Cervical Squamous Intraepithelial Lesions.
M. C.M. Guimaraes, M. A. G. Goncalves, C. P. Soares, J. S.R. Bettini, R. A. Duarte, and E. G. Soares (2005)
J. Histochem. Cytochem. 53, 509-516
   Abstract »    Full Text »    PDF »
The E6AP Ubiquitin Ligase Is Required for Transactivation of the hTERT Promoter by the Human Papillomavirus E6 Oncoprotein.
X. Liu, H. Yuan, B. Fu, G. L. Disbrow, T. Apolinario, V. Tomaic, M. L. Kelley, C. C. Baker, J. Huibregtse, and R. Schlegel (2005)
J. Biol. Chem. 280, 10807-10816
   Abstract »    Full Text »    PDF »
The E7 Protein of Cutaneous Human Papillomavirus Type 8 Causes Invasion of Human Keratinocytes into the Dermis in Organotypic Cultures of Skin.
B. Akgul, R. Garcia-Escudero, L. Ghali, H. J. Pfister, P. G. Fuchs, H. Navsaria, and A. Storey (2005)
Cancer Res. 65, 2216-2223
   Abstract »    Full Text »    PDF »
Inhibition of Human Papillomavirus Type 16 E7 Phosphorylation by the S100 MRP-8/14 Protein Complex.
S. Tugizov, J. Berline, R. Herrera, M. E. Penaranda, M. Nakagawa, and J. Palefsky (2005)
J. Virol. 79, 1099-1112
   Abstract »    Full Text »    PDF »
Macrophages Kill Human Papillomavirus Type 16 E6-Expressing Tumor Cells by Tumor Necrosis Factor Alpha- and Nitric Oxide-Dependent Mechanisms.
J. M. Routes, K. Morris, M. C. Ellison, and S. Ryan (2005)
J. Virol. 79, 116-123
   Abstract »    Full Text »    PDF »
Association of specific genotype and haplotype of p53 gene with cervical cancer in India.
S Mitra, C Misra, R K Singh, C K Panda, and S Roychoudhury (2005)
J. Clin. Pathol. 58, 26-31
   Abstract »    Full Text »    PDF »
Cyclin A expression and growth in suspension can be uncoupled from p27 deregulation and extracellular signal-regulated kinase activity in cells transformed by bovine papillomavirus type 4 E5.
M. Zago, M. S. Campo, and V. O'Brien (2004)
J. Gen. Virol. 85, 3585-3595
   Abstract »    Full Text »    PDF »
Role of the PDZ Domain-Binding Motif of the Oncoprotein E6 in the Pathogenesis of Human Papillomavirus Type 31.
C. Lee and L. A. Laimins (2004)
J. Virol. 78, 12366-12377
   Abstract »    Full Text »    PDF »
Mechanisms of Human Papillomavirus-Induced Oncogenesis.
K. Munger, A. Baldwin, K. M. Edwards, H. Hayakawa, C. L. Nguyen, M. Owens, M. Grace, and K. Huh (2004)
J. Virol. 78, 11451-11460
   Full Text »    PDF »
Effect of Human Papillomavirus-16 Infection on CD8+ T-Cell Recognition of a Wild-Type Sequence p53264-272 Peptide in Patients with Squamous Cell Carcinoma of the Head and Neck.
N. Sirianni, P. K. Ha, M. Oelke, J. Califano, W. Gooding, W. Westra, T. L. Whiteside, W. M. Koch, J. P. Schneck, A. DeLeo, et al. (2004)
Clin. Cancer Res. 10, 6929-6937
   Abstract »    Full Text »    PDF »
Degradation of hDlg and MAGIs by human papillomavirus E6 is E6-AP-independent.
H. S. Grm and L. Banks (2004)
J. Gen. Virol. 85, 2815-2819
   Abstract »    Full Text »    PDF »
ORF73 of Herpesvirus Saimiri, a Viral Homolog of Kaposi's Sarcoma-Associated Herpesvirus, Modulates the Two Cellular Tumor Suppressor Proteins p53 and pRb.
S. Borah, S. C. Verma, and E. S. Robertson (2004)
J. Virol. 78, 10336-10347
   Abstract »    Full Text »    PDF »
Human Papillomavirus 16 E6 Oncoprotein Interferences with Insulin Signaling Pathway by Binding to Tuberin.
Z. Lu, X. Hu, Y. Li, L. Zheng, Y. Zhou, H. Jiang, T. Ning, Z. Basang, C. Zhang, and Y. Ke (2004)
J. Biol. Chem. 279, 35664-35670
   Abstract »    Full Text »    PDF »
Does a Sentinel or a Subset of Short Telomeres Determine Replicative Senescence?.
Y. Zou, A. Sfeir, S. M. Gryaznov, J. W. Shay, and W. E. Wright (2004)
Mol. Biol. Cell 15, 3709-3718
   Abstract »    Full Text »    PDF »
THE ROLE OF HUMAN PAPILLOMAVIRUS IN ORAL CARCINOGENESIS.
P. K. Ha and J. A. Califano (2004)
Crit. Rev. Oral. Biol. Med. 15, 188-196
   Abstract »    Full Text »    PDF »
Pathogenesis of Human Papillomaviruses in Differentiating Epithelia.
M. S. Longworth and L. A. Laimins (2004)
Microbiol. Mol. Biol. Rev. 68, 362-372
   Abstract »    Full Text »    PDF »
Ubiquitination and proteasome degradation of the E6 proteins of human papillomavirus types 11 and 18.
D. Stewart, S. Kazemi, S. Li, P. Massimi, L. Banks, A. E. Koromilas, and G. Matlashewski (2004)
J. Gen. Virol. 85, 1419-1426
   Abstract »    Full Text »    PDF »
Degradation of p53, Not Telomerase Activation, by E6 Is Required for Bypass of Crisis and Immortalization by Human Papillomavirus Type 16 E6/E7.
H. R. McMurray and D. J. McCance (2004)
J. Virol. 78, 5698-5706
   Abstract »    Full Text »    PDF »
Comparison of the Rta/Orf50 Transactivator Proteins of Gamma-2-Herpesviruses.
B. Damania, J. H. Jeong, B. S. Bowser, S. M. DeWire, M. R. Staudt, and D. P. Dittmer (2004)
J. Virol. 78, 5491-5499
   Abstract »    Full Text »    PDF »
p73 Expression Is Associated with the Cellular Radiosensitivity in Cervical Cancer after Radiotherapy.
S. S. Liu, R. C.-Y. Leung, K. Y.-K. Chan, P.-M. Chiu, A. N.-Y. Cheung, K.-F. Tam, T.-Y. Ng, L.-C. Wong, and H. Y.-S. Ngan (2004)
Clin. Cancer Res. 10, 3309-3316
   Abstract »    Full Text »    PDF »
Role of the Retinoblastoma Pathway in Senescence Triggered by Repression of the Human Papillomavirus E7 Protein in Cervical Carcinoma Cells.
A. Psyrri, R. A. DeFilippis, A. P. B. Edwards, K. E. Yates, L. Manuelidis, and D. DiMaio (2004)
Cancer Res. 64, 3079-3086
   Abstract »    Full Text »    PDF »
Roles of the E6 and E7 Proteins in the Life Cycle of Low-Risk Human Papillomavirus Type 11.
S. T. Oh, M. S. Longworth, and L. A. Laimins (2004)
J. Virol. 78, 2620-2626
   Abstract »    Full Text »    PDF »
Requirement of PDZ-Containing Proteins for Cell Cycle Regulation and Differentiation in the Mouse Lens Epithelium.
M. M. Nguyen, M. L. Nguyen, G. Caruana, A. Bernstein, P. F. Lambert, and A. E. Griep (2003)
Mol. Cell. Biol. 23, 8970-8981
   Abstract »    Full Text »    PDF »
Signals That Dictate Nuclear Localization of Human Papillomavirus Type 16 Oncoprotein E6 in Living Cells.
M. Tao, M. Kruhlak, S. Xia, E. Androphy, and Z.-M. Zheng (2003)
J. Virol. 77, 13232-13247
   Abstract »    Full Text »    PDF »
A promoter within the E6 ORF of human papillomavirus type 16 contributes to the expression of the E7 oncoprotein from a monocistronic mRNA.
J. A. Glahder, C. N. Hansen, J. Vinther, B. S. Madsen, and B. Norrild (2003)
J. Gen. Virol. 84, 3429-3441
   Abstract »    Full Text »    PDF »
Fanconi anemia type C and p53 cooperate in apoptosis and tumorigenesis.
B. Freie, X. Li, S. L. M. Ciccone, K. Nawa, S. Cooper, C. Vogelweid, L. Schantz, L. S. Haneline, A. Orazi, H. E. Broxmeyer, et al. (2003)
Blood 102, 4146-4152
   Abstract »    Full Text »    PDF »
Human Papillomavirus DNA and p53 Polymorphisms in Squamous Cell Carcinomas From Fanconi Anemia Patients.
D. I. Kutler, V. B. Wreesmann, A. Goberdhan, L. Ben-Porat, J. Satagopan, I. Ngai, A. G. Huvos, P. Giampietro, O. Levran, K. Pujara, et al. (2003)
J Natl Cancer Inst 95, 1718-1721
   Abstract »    Full Text »    PDF »
Mouse Models to Study the Interaction of Risk Factors for Human Liver Cancer.
S. Sell (2003)
Cancer Res. 63, 7553-7562
   Abstract »    Full Text »    PDF »
Keratinocyte Growth Conditions Modulate Telomerase Expression, Senescence, and Immortalization by Human Papillomavirus Type 16 E6 and E7 Oncogenes.
B. Fu, J. Quintero, and C. C. Baker (2003)
Cancer Res. 63, 7815-7824
   Abstract »    Full Text »    PDF »
Direct Activation of Cyclin-Dependent Kinase 2 by Human Papillomavirus E7.
W. He, D. Staples, C. Smith, and C. Fisher (2003)
J. Virol. 77, 10566-10574
   Abstract »    Full Text »    PDF »
Human Papillomavirus Type 16 E6 Activates TERT Gene Transcription through Induction of c-Myc and Release of USF-Mediated Repression.
H. R. McMurray and D. J. McCance (2003)
J. Virol. 77, 9852-9861
   Abstract »    Full Text »    PDF »
Early Stage Cervical Cancers Containing Human Papillomavirus Type 18 DNA Have More Nodal Metastasis and Deeper Stromal Invasion.
S. S. Im, S. P. Wilczynski, R. A. Burger, and B. J. Monk (2003)
Clin. Cancer Res. 9, 4145-4150
   Abstract »    Full Text »    PDF »
Depletion of Langerhans Cells in Human Papillomavirus Type 16-Infected Skin Is Associated with E6-Mediated Down Regulation of E-Cadherin.
K. Matthews, C. M. Leong, L. Baxter, E. Inglis, K. Yun, B. T. Backstrom, J. Doorbar, and M. Hibma (2003)
J. Virol. 77, 8378-8385
   Abstract »    Full Text »    PDF »
Human papillomavirus E6 and Myc proteins associate in vivo and bind to and cooperatively activate the telomerase reverse transcriptase promoter.
T. Veldman, X. Liu, H. Yuan, and R. Schlegel (2003)
PNAS 100, 8211-8216
   Abstract »    Full Text »    PDF »
Study of viral integration of HPV-16 in young patients with LSIL.
G Gallo, M Bibbo, L Bagella, A Zamparelli, F Sanseverino, M R Giovagnoli, A Vecchione, and A Giordano (2003)
J. Clin. Pathol. 56, 532-536
   Abstract »    Full Text »    PDF »
Adenovirus E1A, Not Human Papillomavirus E7, Sensitizes Tumor Cells to Lysis by Macrophages Through Nitric Oxide- and TNF-{alpha}-Dependent Mechanisms Despite Up-Regulation of 70-kDa Heat Shock Protein.
T. A. Miura, K. Morris, S. Ryan, J. L. Cook, and J. M. Routes (2003)
J. Immunol. 170, 4119-4126
   Abstract »    Full Text »    PDF »
Human Papillomavirus Type 31 E5 Protein Supports Cell Cycle Progression and Activates Late Viral Functions upon Epithelial Differentiation.
F. Fehrmann, D. J. Klumpp, and L. A. Laimins (2003)
J. Virol. 77, 2819-2831
   Abstract »    Full Text »    PDF »
Inhibition of human papilloma virus E2 DNA binding protein by covalently linked polyamides.
T. D. Schaal, W. G. Mallet, D. L. McMinn, N. V. Nguyen, M. M. Sopko, S. John, and B. S. Parekh (2003)
Nucleic Acids Res. 31, 1282-1291
   Abstract »    Full Text »    PDF »
The High-Risk Human Papillomavirus Type 16 E6 Counters the GAP Function of E6TP1 toward Small Rap G Proteins.
L. Singh, Q. Gao, A. Kumar, T. Gotoh, D. E. Wazer, H. Band, L. A. Feig, and V. Band (2002)
J. Virol. 77, 1614-1620
   Abstract »    Full Text »    PDF »
Both E7 and CpG-Oligodeoxynucleotide Are Required for Protective Immunity against Challenge with Human Papillomavirus 16 (E6/E7) Immortalized Tumor Cells: Involvement of CD4+ and CD8+ T Cells in Protection.
T.-Y. Kim, H.-J. Myoung, J.-H. Kim, I.-S. Moon, T.-G. Kim, W.-S. Ahn, and J.-I. Sin (2002)
Cancer Res. 62, 7234-7240
   Abstract »    Full Text »    PDF »
Ubiquitin-Dependent Proteolysis of Cyclin D1 Is Associated with Coxsackievirus-Induced Cell Growth Arrest.
H. Luo, J. Zhang, F. Dastvan, B. Yanagawa, M. A. Reidy, H. M. Zhang, D. Yang, J. E. Wilson, and B. M. McManus (2002)
J. Virol. 77, 1-9
   Abstract »    Full Text »    PDF »
Tumor Suppressor Activity of AP2alpha Mediated through a Direct Interaction with p53.
L. A. McPherson, A. V. Loktev, and R. J. Weigel (2002)
J. Biol. Chem. 277, 45028-45033
   Abstract »    Full Text »    PDF »
A Mutant of Human Papillomavirus Type 16 E6 Deficient in Binding {alpha}-Helix Partners Displays Reduced Oncogenic Potential In Vivo.
M. Nguyen, S. Song, A. Liem, E. Androphy, Y. Liu, and P. F. Lambert (2002)
J. Virol. 76, 13039-13048
   Abstract »    Full Text »    PDF »
The Human Papillomavirus Type 16 E5 Protein Impairs TRAIL- and FasL-Mediated Apoptosis in HaCaT Cells by Different Mechanisms.
K. Kabsch and A. Alonso (2002)
J. Virol. 76, 12162-12172
   Abstract »    Full Text »    PDF »
Establishment of an HLA-A*0201 Human Papillomavirus Type 16 Tumor Model to Determine the Efficacy of Vaccination Strategies in HLA-A*0201 Transgenic Mice.
G. L. Eiben, M. P. Velders, H. Schreiber, M. C. Cassetti, J. K. Pullen, L. R. Smith, and W. M. Kast (2002)
Cancer Res. 62, 5792-5799
   Abstract »    Full Text »    PDF »
Modulation of the Cell Division Cycle by Human Papillomavirus Type 18 E4.
T. Nakahara, A. Nishimura, M. Tanaka, T. Ueno, A. Ishimoto, and H. Sakai (2002)
J. Virol. 76, 10914-10920
   Abstract »    Full Text »    PDF »
The Upstream Regulatory Region of Human Papillomavirus Type 31 Is Insensitive to Glucocorticoid Induction.
J. L. Bromberg-White and C. Meyers (2002)
J. Virol. 76, 9702-9715
   Abstract »    Full Text »    PDF »
Transcriptional Regulation of the mdm2 Oncogene by p53 Requires TRRAP Acetyltransferase Complexes.
P. G. Ard, C. Chatterjee, S. Kunjibettu, L. R. Adside, L. E. Gralinski, and S. B. McMahon (2002)
Mol. Cell. Biol. 22, 5650-5661
   Abstract »    Full Text »    PDF »
Human Papillomavirus Oncoprotein E6 Inactivates the Transcriptional Coactivator Human ADA3.
A. Kumar, Y. Zhao, G. Meng, M. Zeng, S. Srinivasan, L. M