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Science 30 March 1990:
Vol. 247. no. 4950, pp. 1589 - 1591
DOI: 10.1126/science.2321020
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Articles

Science, Vol 247, Issue 4950, 1589-1591
Copyright © 1990 by American Association for the Advancement of Science

articles

Endogenous cholecystokinin reduces feeding in young rats

A Weller, GP Smith, and J Gibbs

Department of Psychiatry, Cornell University Medical College, White Plains, NY.

The hypothesis that endogenous cholecystokinin (CCK) released from the small intestine during feeding causes satiety was tested in rat pups, 9 to 12 days old. Intragastric administration of soybean trypsin inhibitor, a procedure that releases CCK from the small intestine, decreased the subsequent intake of a test meal. This effect was reversed by prior treatment with MK-329, a selective antagonist of CCK at alimentary-type CCK (CCK-A) receptors. Thus, endogenous, small intestinal CCK can cause satiety in the neonatal rat and this effect involves CCK-A receptors.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Endogenous cholecystokinin reduces food intake and increases Fos-like immunoreactivity in the dorsal vagal complex but not in the myenteric plexus by CCK1 receptor in the adult rat.
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Am J Physiol Regulatory Integrative Comp Physiol 292, R1071-R1080
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Metabolic imprinting: critical impact of the perinatal environment on the regulation of energy homeostasis.
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Independent ingestion and microstructure of feeding patterns in infant rats lacking CCK-1 receptors.
S. Blumberg, D. Haba, M. Schroeder, G. P. Smith, and A. Weller (2006)
Am J Physiol Regulatory Integrative Comp Physiol 290, R208-R218
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Peripheral Interaction of Ghrelin with Cholecystokinin on Feeding Regulation.
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Interaction between CCK and a preload on reduction of food intake is mediated by CCK-A receptors in humans.
J.-P. Gutzwiller, J. Drewe, S. Ketterer, P. Hildebrand, A. Krautheim, and C. Beglinger (2000)
Am J Physiol Regulatory Integrative Comp Physiol 279, R189-R195
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Role of cholecystokinin in the anorexia produced by duodenal delivery of peptone in rats.
T. Woltman and R. Reidelberger (1999)
Am J Physiol Regulatory Integrative Comp Physiol 276, R1701-R1709
   Abstract »    Full Text »    PDF »
Synergistic interaction between leptin and cholecystokinin to reduce short-term food intake in lean mice.
M. D. Barrachina, V. Martinez, L. Wang, J. Y. Wei, and Y. Tache (1997)
PNAS 94, 10455-10460
   Abstract »    Full Text »    PDF »


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