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Science 23 March 1990:
Vol. 247. no. 4949, pp. 1471 - 1474
DOI: 10.1126/science.2321009
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Articles

Science, Vol 247, Issue 4949, 1471-1474
Copyright © 1990 by American Association for the Advancement of Science

articles

Thymic epithelium tolerizes for histocompatibility antigens

J Salaun, A Bandeira, I Khazaal, F Calman, M Coltey, A Coutinho, and NM Le Douarin

Instit d'Embryologie cellulaire et moleculaire du CNRS, College de France, Nogent-sur-Marne.

The role of thymic epithelium in the establishment of tissue tolerance was analyzed with a murine chimeric system. All T cells differentiated from birth onward in a thymus comprising allogeneic epithelium and syngeneic hematopoietic cells. Embryonic thymic rudiments that contained no hematopoietic cells from C3H (H-2k) donors were grafted to newborn athymic (nude) BALB/c (H-2d) mice. Chimeras that had normal T cell numbers and function rejected third-party skin grafts, but permanently accepted grafts syngeneic to the thymic epithelium. In vitro functional assays did not always correlate with the state of tolerance in vivo. Thus, pure thymic epithelium induces tolerance to histocompatibility antigens.


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