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Science 16 March 1990:
Vol. 247. no. 4948, pp. 1341 - 1344
DOI: 10.1126/science.2107575

Articles

Science, Vol 247, Issue 4948, 1341-1344
Copyright © 1990 by American Association for the Advancement of Science


articles

Hypoxic dilation of coronary arteries is mediated by ATP-sensitive potassium channels

J Daut, W Maier-Rudolph, N von Beckerath, G Mehrke, K Gunther, and L Goedel-Meinen

Physiologisches Institut der Technischen Universitat Munchen, Biedersteiner, Federal Republic of Germany.

The function of the heart depends critically on an adequate oxygen supply through the coronary arteries. Coronary arteries dilate when the intravascular oxygen tension decreases. Hypoxic vasodilation in isolated, perfused guinea pig hearts can be prevented by glibenclamide, a blocker of adenosine triphosphate (ATP)-sensitive potassium channels, and can be mimicked by cromakalim, which opens ATP-sensitive potassium channels. Opening of potassium channels in coronary smooth muscle cells and the subsequent drop in intracellular calcium is probably the major cause of hypoxic and ischemic vasodilation in the mammalian heart.


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Bimakalim, an ATP-Sensitive Potassium Channel Opener, Mimics the Effects of Ischemic Preconditioning to Reduce Infarct Size, Adenosine Release, and Neutrophil Function in Dogs.
T. Mizumura, K. Nithipatikom, and G. J. Gross (1995)
Circulation 92, 1236-1245
   Abstract »    Full Text »
Glibenclamide, a Selective Inhibitor of ATP-Sensitive K+ Channels, Attenuates Metabolic Coronary Vasodilatation Induced by Pacing Tachycardia in Dogs.
Y. Katsuda, K. Egashira, H. Ueno, Y. Akatsuka, T. Narishige, Y. Arai, T. Takayanagi, H. Shimokawa, and A. Takeshita (1995)
Circulation 92, 511-517
   Abstract »    Full Text »
Longitudinal Gradients for Endothelium-Dependent and -Independent Vascular Responses in the Coronary Microcirculation.
L. Kuo, M. J. Davis, and W. M. Chilian (1995)
Circulation 92, 518-525
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Relaxation of the Aorta During Hypoxia Is Impaired in Chronically Hypertensive Rats.
H. Taguchi, F. M. Faraci, T. Kitazono, and D. D. Heistad (1995)
Hypertension 25, 735-738
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ATP-Sensitive K+ Channels Mediate {alpha}2D-Adrenergic Receptor Contraction of Arteriolar Smooth Muscle and Reversal of Contraction by Hypoxia.
J. Tateishi and J. E. Faber (1995)
Circ. Res. 76, 53-63
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Cardiac Preconditioning: Induction of Endogenous Tolerance to Ischemia-Reperfusion Injury.
D. R. Meldrum, M. B. Mitchell, A. Banerjee, and A. H. Harken (1993)
Arch Surg 128, 1208-1211
   Abstract »    PDF »
Vasodilative Response to Hypoxia and Simulated Ischemia Is Mediated by ATP-Sensitive K + Channels in Guinea Pig Thoracic Aorta.
R. Gasser, W. Klein, and E. Kickenweiz (1993)
Angiology 44, 228-243
   Abstract »    PDF »



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Science. ISSN 0036-8075 (print), 1095-9203 (online)