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Science 16 March 1990: Vol. 247. no. 4948, pp. 1341 - 1344 DOI: 10.1126/science.2107575
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Articles
Science, Vol 247, Issue 4948, 1341-1344
Copyright © 1990 by American Association for the Advancement of Science
Hypoxic dilation of coronary arteries is mediated by ATP-sensitive potassium channels
J Daut,
W Maier-Rudolph,
N von Beckerath,
G Mehrke,
K Gunther,
and
L Goedel-Meinen
Physiologisches Institut der Technischen Universitat Munchen, Biedersteiner, Federal Republic of Germany.
The function of the heart depends critically on an adequate oxygen supply through the coronary arteries. Coronary arteries dilate when the intravascular oxygen tension decreases. Hypoxic vasodilation in isolated, perfused guinea pig hearts can be prevented by glibenclamide, a blocker of adenosine triphosphate (ATP)-sensitive potassium channels, and can be mimicked by cromakalim, which opens ATP-sensitive potassium channels. Opening of potassium channels in coronary smooth muscle cells and the subsequent drop in intracellular calcium is probably the major cause of hypoxic and ischemic vasodilation in the mammalian heart.
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- Distribution and Physiological Roles of ATP-Sensitive K+ Channels in the Vertebrobasilar System of the Rabbit.
- T. Nagao, S. Ibayashi, S. Sadoshima, K. Fujii, K. Fujii, Y. Ohya, and M. Fujishima (1996)
Circ. Res.
78, 238-243
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- Acidosis-Induced Coronary Arteriolar Dilation Is Mediated by ATP-Sensitive Potassium Channels in Vascular Smooth Muscle.
- H. Ishizaka and L. Kuo (1996)
Circ. Res.
78, 50-57
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- Pharmacological Evidence for the Persistent Activation of ATP-Sensitive K+ Channels in Early Phase of Reperfusion and Its Protective Role Against Myocardial Stunning.
- S. Shigematsu, T. Sato, T. Abe, T. Saikawa, T. Sakata, and M. Arita (1995)
Circulation
92, 2266-2275
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- ADENOSINE TRIPHOSPHATE-SENSITIVE K+ CHANNELS MEDIATE POSTCARDIOPLEGIA CORONARY HYPEREMIA.
- S. Y. Wang, M. Friedman, R. G. Johnson, A. J. Zeind, and F. W. Sellke (1995)
J. Thorac. Cardiovasc. Surg.
110, 1073-1082
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- Relaxation of the Carotid Artery to Hypoxia Is Impaired in Watanabe Heritable Hyperlipidemic Rabbits.
- H. Taguchi, F. M. Faraci, T. Kitazono, and D. D. Heistad (1995)
Arterioscler Thromb Vasc Biol
15, 1641-1645
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- Direct In Vivo Observation of Subendocardial Arteriolar Response During Reactive Hyperemia.
- T. Yada, O. Hiramatsu, A. Kimura, H. Tachibana, Y. Chiba, S. Lu, M. Goto, Y. Ogasawara, K. Tsujioka, and F. Kajiya (1995)
Circ. Res.
77, 622-631
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- Bimakalim, an ATP-Sensitive Potassium Channel Opener, Mimics the Effects of Ischemic Preconditioning to Reduce Infarct Size, Adenosine Release, and Neutrophil Function in Dogs.
- T. Mizumura, K. Nithipatikom, and G. J. Gross (1995)
Circulation
92, 1236-1245
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- Glibenclamide, a Selective Inhibitor of ATP-Sensitive K+ Channels, Attenuates Metabolic Coronary Vasodilatation Induced by Pacing Tachycardia in Dogs.
- Y. Katsuda, K. Egashira, H. Ueno, Y. Akatsuka, T. Narishige, Y. Arai, T. Takayanagi, H. Shimokawa, and A. Takeshita (1995)
Circulation
92, 511-517
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- Longitudinal Gradients for Endothelium-Dependent and -Independent Vascular Responses in the Coronary Microcirculation.
- L. Kuo, M. J. Davis, and W. M. Chilian (1995)
Circulation
92, 518-525
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- Relaxation of the Aorta During Hypoxia Is Impaired in Chronically Hypertensive Rats.
- H. Taguchi, F. M. Faraci, T. Kitazono, and D. D. Heistad (1995)
Hypertension
25, 735-738
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- ATP-Sensitive K+ Channels Mediate {alpha}2D-Adrenergic Receptor Contraction of Arteriolar Smooth Muscle and Reversal of Contraction by Hypoxia.
- J. Tateishi and J. E. Faber (1995)
Circ. Res.
76, 53-63
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- Cardiac Preconditioning: Induction of Endogenous Tolerance to Ischemia-Reperfusion Injury.
- D. R. Meldrum, M. B. Mitchell, A. Banerjee, and A. H. Harken (1993)
Arch Surg
128, 1208-1211
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- Vasodilative Response to Hypoxia and Simulated Ischemia Is Mediated by ATP-Sensitive K + Channels in Guinea Pig Thoracic Aorta.
- R. Gasser, W. Klein, and E. Kickenweiz (1993)
Angiology
44, 228-243
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