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Science 23 February 1990: Vol. 247. no. 4945, pp. 975 - 978 DOI: 10.1126/science.2305266
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Articles
Science, Vol 247, Issue 4945, 975-978
Copyright © 1990 by American Association for the Advancement of Science
Transplanted suprachiasmatic nucleus determines circadian period
MR Ralph,
RG Foster,
FC Davis,
and
M Menaker
Department of Biology, University of Virginia, Charlottesville 22903.
The pacemaker role of the suprachiasmatic nucleus in a mammalian circadian system was tested by neural transplantation by using a mutant strain of hamster that shows a short circadian period. Small neural grafts from the suprachiasmatic region restored circadian rhythms to arrhythmic animals whose own nucleus had been ablated. The restored rhythms always exhibited the period of the donor genotype regardless of the direction of the transplant or genotype of the host. The basic period of the overt circadian rhythm therefore is determined by cells of the suprachiasmatic region.
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Am J Physiol Regulatory Integrative Comp Physiol
278, R1385-R1389
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- Resetting Central and Peripheral Circadian Oscillators in Transgenic Rats.
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Science
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- Positional Syntenic Cloning and Functional Characterization of the Mammalian Circadian Mutation tau.
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- Relationship of atypical melatonin rhythm with two circadian clock outputs in B6D2F1 mice.
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Am J Physiol Regulatory Integrative Comp Physiol
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- CLOCK, an essential pacemaker component, controls expression of the circadian transcription factor DBP.
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- The Suprachiasmatic Nucleus in Organotypic Slice Cultures of the Common Vole (Microtus arvalis): Comparison of Development with Rat and Hamster and the Effect of Age.
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J Biol Rhythms
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- Circadian rhythms in the chemoreflex control of breathing.
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Am J Physiol Regulatory Integrative Comp Physiol
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