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Science 19 January 1990:
Vol. 247. no. 4940, pp. 327 - 329
DOI: 10.1126/science.2153316
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Articles

Science, Vol 247, Issue 4940, 327-329
Copyright © 1990 by American Association for the Advancement of Science

articles

Microinjection of a conserved peptide sequence of p34cdc2 induces a Ca2+ transient in oocytes

A Picard, JC Cavadore, P Lory, JC Bernengo, C Ojeda, and M Doree

CNRS and INSERM, Montpellier, France.

The product of the yeast cell cycle control gene cdc2, and its homologs in higher eukaryotes (p34cdc2), all contain a perfectly conserved sequence of 16 amino acids that has not been found in any other protein sequence. Microinjection of this peptide triggers a specific increase in the concentration of intracellular free Ca2+ that originates from intracellular stores in both starfish and Xenopus oocytes. Thus, p34cdc2 might interact through its conserved peptide domain with some component of the Ca2(+)-regulatory system.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Adenophostin A Can Stimulate Ca2+ Influx without Depleting the Inositol 1,4,5-Trisphosphate-sensitive Ca2+ Stores in the Xenopus Oocyte.
S. DeLisle, E. W. Marksberry, C. Bonnett, D. J. Jenkins, B. V.L. Potter, M. Takahashi, and K. Tanzawa (1997)
J. Biol. Chem. 272, 9956-9961
   Abstract »    Full Text »    PDF »
An endogenous calcium oscillator may control early embryonic division.
C. A. Swanson, A. P. Arkin, and J. Ross (1997)
PNAS 94, 1194-1199
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Histone H1 kinase activity, germinal vesicle breakdown and M phase entry in mouse oocytes.
A. Gavin, J. Cavadore, and S Schorderet-Slatkine (1994)
J. Cell Sci. 107, 275-283
   Abstract »    PDF »
Calreticulin Modulates Capacitative Ca2+ Influx by Controlling the Extent of Inositol 1,4,5-Trisphosphate-induced Ca2+ Store Depletion.
W. Xu, F. J. Longo, M. R. Wintermantel, X. Jiang, R. A. Clark, and S. DeLisle (2000)
J. Biol. Chem. 275, 36676-36682
   Abstract »    Full Text »    PDF »


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