Science 19 January 1990: Vol. 247. no. 4940, pp. 322 - 324 DOI: 10.1126/science.2296722

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Articles

Wnt Signaling Stimulates Transcriptional Outcome of the Hedgehog Pathway by Stabilizing GLI1 mRNA.

F. K. Noubissi, S. Goswami, N. A. Sanek, K. Kawakami, T. Minamoto, A. Moser, Y. Grinblat, and V. S. Spiegelman (2009)
Cancer Res. 69, 8572-8578
 |  Abstract »  |  Full Text »  |  PDF »

Overactive Beta-Catenin Signaling Causes Testicular Sertoli Cell Tumor Development in the Mouse.

H. Chang, F. Guillou, M. M. Taketo, and R. R. Behringer (2009)
Biol Reprod 81, 842-849
 |  Abstract »  |  Full Text »  |  PDF »

Discovery and validation of colonic tumor-associated proteins via metabolic labeling and stable isotopic dilution.

E. L. Huttlin, X. Chen, G. A. Barrett-Wilt, A. D. Hegeman, R. B. Halberg, A. C. Harms, M. A. Newton, W. F. Dove, and M. R. Sussman (2009)
PNAS 106, 17235-17240
 |  Abstract »  |  Full Text »  |  PDF »

REVIEW PAPER: Implications of the "Cancer Stem Cell" Hypothesis on Murine Models of Colon Cancer and Colitis-associated Cancer.

M. J. Hynes, K. M. Huang, and E. H. Huang (2009)
Vet. Pathol. 46, 819-835
 |  Abstract »  |  Full Text »  |  PDF »

Disruption of estrogen receptor signaling enhances intestinal neoplasia in ApcMin/+ mice.

A. G. Cleveland, S. I. Oikarinen, K. K. Bynote, M. Marttinen, J. J. Rafter, J.-A. Gustafsson, S. K. Roy, H. C. Pitot, K. S. Korach, D. B. Lubahn, et al. (2009)
Carcinogenesis 30, 1581-1590
 |  Abstract »  |  Full Text »  |  PDF »

Hyperaldosteronism, hypervolemia, and increased blood pressure in mice expressing defective APC.

M. Bhandaru, D. S. Kempe, A. Rotte, R. Rexhepaj, D. Kuhl, and F. Lang (2009)
Am J Physiol Regulatory Integrative Comp Physiol 297, R571-R575
 |  Abstract »  |  Full Text »  |  PDF »

Aryl hydrocarbon receptor suppresses intestinal carcinogenesis in ApcMin/+ mice with natural ligands.

K. Kawajiri, Y. Kobayashi, F. Ohtake, T. Ikuta, Y. Matsushima, J. Mimura, S. Pettersson, R. S. Pollenz, T. Sakaki, T. Hirokawa, et al. (2009)
PNAS 106, 13481-13486
 |  Abstract »  |  Full Text »  |  PDF »

Phospholipase C{varepsilon} promotes intestinal tumorigenesis of ApcMin/+ mice through augmentation of inflammation and angiogenesis.

M. Li, H. Edamatsu, R. Kitazawa, S. Kitazawa, and T. Kataoka (2009)
Carcinogenesis 30, 1424-1432
 |  Abstract »  |  Full Text »  |  PDF »

The Links between Transcription, {beta}-catenin/JNK Signaling, and Carcinogenesis.

A. Saadeddin, R. Babaei-Jadidi, B. Spencer-Dene, and A. S. Nateri (2009)
Mol. Cancer Res. 7, 1189-1196
 |  Abstract »  |  Full Text »  |  PDF »

SirT1 Is an Inhibitor of Proliferation and Tumor Formation in Colon Cancer.

N. Kabra, Z. Li, L. Chen, B. Li, X. Zhang, C. Wang, T. Yeatman, D. Coppola, and J. Chen (2009)
J. Biol. Chem. 284, 18210-18217
 |  Abstract »  |  Full Text »  |  PDF »

5-Aminosalicylic acid inhibits colitis-associated but not sporadic colorectal neoplasia in a novel conditional Apc mouse model.

P. J. Koelink, E. C. Robanus-Maandag, P. Devilee, D. W. Hommes, C. B.H.W. Lamers, and H. W. Verspaget (2009)
Carcinogenesis 30, 1217-1224
 |  Abstract »  |  Full Text »  |  PDF »

The Interaction of a High-Fat Diet and Regular Moderate Intensity Exercise on Intestinal Polyp Development in ApcMin/+ Mice.

K. A. Baltgalvis, F. G. Berger, M. M. O. Pena, J. M. Davis, and J. A. Carson (2009)
Cancer Prevention Research 2, 641-649
 |  Abstract »  |  Full Text »  |  PDF »

PUMA Suppresses Intestinal Tumorigenesis in Mice.

W. Qiu, E. B. Carson-Walter, S. F. Kuan, L. Zhang, and J. Yu (2009)
Cancer Res. 69, 4999-5006
 |  Abstract »  |  Full Text »  |  PDF »

Methylenetetrahydrofolate reductase deficiency and low dietary folate reduce tumorigenesis in Apcmin/+ mice.

A K Lawrance, L Deng, and R Rozen (2009)
Gut 58, 805-811
 |  Abstract »  |  Full Text »  |  PDF »

3,3'-Diindolylmethane Enhances the Efficacy of Butyrate in Colon Cancer Prevention through Down-Regulation of Survivin.

N. Bhatnagar, X. Li, Y. Chen, X. Zhou, S. H. Garrett, and B. Guo (2009)
Cancer Prevention Research 2, 581-589
 |  Abstract »  |  Full Text »  |  PDF »

Haploinsufficiency of Kruppel-Like Factor 5 Rescues the Tumor-Initiating Effect of the ApcMin Mutation in the Intestine.

B. B. McConnell, A. B. Bialkowska, M. O. Nandan, A. M. Ghaleb, F. J. Gordon, and V. W. Yang (2009)
Cancer Res. 69, 4125-4133
 |  Abstract »  |  Full Text »  |  PDF »

Identification of Early Intestinal Neoplasia Protein Biomarkers Using Laser Capture Microdissection and MALDI MS.

B. J. Xu, J. Li, R. D. Beauchamp, Y. Shyr, M. Li, M. K. Washington, T. J. Yeatman, R. H. Whitehead, R. J. Coffey, and R. M. Caprioli (2009)
Mol. Cell. Proteomics 8, 936-945
 |  Abstract »  |  Full Text »  |  PDF »

Delivery of CD44 shRNA/Nanoparticles within Cancer Cells: PERTURBATION OF HYALURONAN/CD44v6 INTERACTIONS AND REDUCTION IN ADENOMA GROWTH IN Apc Min/+ MICE.

S. Misra, V. C. Hascall, C. De Giovanni, R. R. Markwald, and S. Ghatak (2009)
J. Biol. Chem. 284, 12432-12446
 |  Abstract »  |  Full Text »  |  PDF »

Jagged1 is the pathological link between Wnt and Notch pathways in colorectal cancer.

V. Rodilla, A. Villanueva, A. Obrador-Hevia, A. Robert-Moreno, V. Fernandez-Majada, A. Grilli, N. Lopez-Bigas, N. Bellora, M. M. Alba, F. Torres, et al. (2009)
PNAS 106, 6315-6320
 |  Abstract »  |  Full Text »  |  PDF »

Establishment of conditionally immortalized epithelial cell lines from the intestinal tissue of adult normal and transgenic mice.

R. H. Whitehead and P. S. Robinson (2009)
Am J Physiol Gastrointest Liver Physiol 296, G455-G460
 |  Abstract »  |  Full Text »  |  PDF »

Farnesoid X Receptor Deficiency in Mice Leads to Increased Intestinal Epithelial Cell Proliferation and Tumor Development.

R. R.M. Maran, A. Thomas, M. Roth, Z. Sheng, N. Esterly, D. Pinson, X. Gao, Y. Zhang, V. Ganapathy, F. J. Gonzalez, et al. (2009)
J. Pharmacol. Exp. Ther. 328, 469-477
 |  Abstract »  |  Full Text »  |  PDF »

Mouse models for the study of colon carcinogenesis.

D. W. Rosenberg, C. Giardina, and T. Tanaka (2009)
Carcinogenesis 30, 183-196
 |  Abstract »  |  Full Text »  |  PDF »

Tgfbr1 Haploinsufficiency Is a Potent Modifier of Colorectal Cancer Development.

Q. Zeng, S. Phukan, Y. Xu, M. Sadim, D. S. Rosman, M. Pennison, J. Liao, G.-Y. Yang, C.-C. Huang, L. Valle, et al. (2009)
Cancer Res. 69, 678-686
 |  Abstract »  |  Full Text »  |  PDF »

Genetic assessment of the importance of galectin-3 in cancer initiation, progression, and dissemination in mice.

I. Eude-Le Parco, G. Gendronneau, T. Dang, D. Delacour, V. L Thijssen, W. Edelmann, M. Peuchmaur, and F. Poirier (2009)
Glycobiology 19, 68-75
 |  Abstract »  |  Full Text »  |  PDF »

Notch Inhibits Expression of the Kruppel-Like Factor 4 Tumor Suppressor in the Intestinal Epithelium.

A. M. Ghaleb, G. Aggarwal, A. B. Bialkowska, M. O. Nandan, and V. W. Yang (2008)
Mol. Cancer Res. 6, 1920-1927
 |  Abstract »  |  Full Text »  |  PDF »

Ku80 Deletion Suppresses Spontaneous Tumors and Induces a p53-Mediated DNA Damage Response.

V. B. Holcomb, F. Rodier, Y. Choi, R. A. Busuttil, H. Vogel, J. Vijg, J. Campisi, and P. Hasty (2008)
Cancer Res. 68, 9497-9502
 |  Abstract »  |  Full Text »  |  PDF »

Period 2 Mutation Accelerates ApcMin/+ Tumorigenesis.

P. A. Wood, X. Yang, A. Taber, E.-Y. Oh, C. Ansell, S. E. Ayers, Z. Al-Assaad, K. Carnevale, F. G. Berger, M. M. O. Pena, et al. (2008)
Mol. Cancer Res. 6, 1786-1793
 |  Abstract »  |  Full Text »  |  PDF »

Glucagon-like Peptide-2 Does Not Modify the Growth or Survival of Murine or Human Intestinal Tumor Cells.

J. A. Koehler, W. Harper, M. Barnard, B. Yusta, and D. J. Drucker (2008)
Cancer Res. 68, 7897-7904
 |  Abstract »  |  Full Text »  |  PDF »

Suppression of Familial Adenomatous Polyposis by CP-31398, a TP53 Modulator, in APCmin/+ Mice.

C. V. Rao, M. V. Swamy, J. M.R. Patlolla, and L. Kopelovich (2008)
Cancer Res. 68, 7670-7675
 |  Abstract »  |  Full Text »  |  PDF »

Deciphering the function of canonical Wnt signals in development and disease: conditional loss- and gain-of-function mutations of {beta}-catenin in mice.

T. Grigoryan, P. Wend, A. Klaus, and W. Birchmeier (2008)
Genes & Dev. 22, 2308-2341
 |  Abstract »  |  Full Text »  |  PDF »

Widespread hyperplasia induced by transgenic TGF{alpha} in ApcMin mice is associated with only regional effects on tumorigenesis.

A. Bilger, R. Sullivan, A. J. Prunuske, L. Clipson, N. R. Drinkwater, and W. F. Dove (2008)
Carcinogenesis 29, 1825-1830
 |  Abstract »  |  Full Text »  |  PDF »

Long-term Epigenetic Therapy with Oral Zebularine Has Minimal Side Effects and Prevents Intestinal Tumors in Mice.

C. B. Yoo, J. C. Chuang, H.-M. Byun, G. Egger, A. S. Yang, L. Dubeau, T. Long, P. W. Laird, V. E. Marquez, and P. A. Jones (2008)
Cancer Prevention Research 1, 233-240
 |  Abstract »  |  Full Text »  |  PDF »

The Pleiotropic Phenotype of Apc Mutations in the Mouse: Allele Specificity and Effects of the Genetic Background.

R. B. Halberg, X. Chen, J. M. Amos-Landgraf, A. White, K. Rasmussen, L. Clipson, C. Pasch, R. Sullivan, H. C. Pitot, and W. F. Dove (2008)
Genetics 180, 601-609
 |  Abstract »  |  Full Text »  |  PDF »

Sulindac treatment alters collagen and matrilysin expression in adenomas of ApcMin/+ mice.

H. Guillen-Ahlers, S. A. Buechler, M. A. Suckow, F. J. Castellino, and V. A. Ploplis (2008)
Carcinogenesis 29, 1421-1427
 |  Abstract »  |  Full Text »  |  PDF »

Helicobacter hepaticus Infection Promotes Colon Tumorigenesis in the BALB/c-Rag2-/- ApcMin/+ Mouse.

C. M. Nagamine, J. J. Sohn, B. H. Rickman, A. B. Rogers, J. G. Fox, and D. B. Schauer (2008)
Infect. Immun. 76, 2758-2766
 |  Abstract »  |  Full Text »  |  PDF »

Lack of DNA mismatch repair protein MSH6 in the rat results in hereditary non-polyposis colorectal cancer-like tumorigenesis.

R. van Boxtel, P. W. Toonen, H. S. van Roekel, M. Verheul, B. M. G. Smits, J. Korving, A. de Bruin, and E. Cuppen (2008)
Carcinogenesis 29, 1290-1297
 |  Abstract »  |  Full Text »  |  PDF »

Deletion of the WNT Target and Cancer Stem Cell Marker CD44 in Apc(Min/+) Mice Attenuates Intestinal Tumorigenesis.

J. Zeilstra, S. P.J. Joosten, M. Dokter, E. Verwiel, M. Spaargaren, and S. T. Pals (2008)
Cancer Res. 68, 3655-3661
 |  Abstract »  |  Full Text »  |  PDF »

Bone marrow-derived circulating endothelial precursors do not contribute to vascular endothelium and are not needed for tumor growth.

S. Purhonen, J. Palm, D. Rossi, N. Kaskenpaa, I. Rajantie, S. Yla-Herttuala, K. Alitalo, I. L. Weissman, and P. Salven (2008)
PNAS 105, 6620-6625
 |  Abstract »  |  Full Text »  |  PDF »

Cellular Expression Patterns of Genes Upregulated in Murine and Human Colonic Neoplasms.

X. Chen, W. M. Ehrhardt, R. B. Halberg, B. J. Aronow, and W. F. Dove (2008)
J. Histochem. Cytochem. 56, 433-441
 |  Abstract »  |  Full Text »  |  PDF »

Effect of exercise on biological pathways in ApcMin/+ mouse intestinal polyps.

K. A. Baltgalvis, F. G. Berger, M. M. O. Pena, J. M. Davis, and J. A. Carson (2008)
J Appl Physiol 104, 1137-1143
 |  Abstract »  |  Full Text »  |  PDF »

Plasminogen activator inhibitor-1 (Pai-1) blockers suppress intestinal polyp formation in Min mice.

M. Mutoh, N. Niho, M. Komiya, M. Takahashi, R. Ohtsubo, K. Nakatogawa, K. Ueda, T. Sugimura, and K. Wakabayashi (2008)
Carcinogenesis 29, 824-829
 |  Abstract »  |  Full Text »  |  PDF »

Dual inhibition of VEGFR and EGFR signaling reduces the incidence and size of intestinal adenomas in ApcMin/+ mice.

D. Alferez, R. W. Wilkinson, J. Watkins, R. Poulsom, N. Mandir, S. R. Wedge, I. T. Pyrah, N. R. Smith, L. Jackson, A. J. Ryan, et al. (2008)
Mol. Cancer Ther. 7, 590-598
 |  Abstract »  |  Full Text »  |  PDF »

Further upregulation of {beta}-catenin/Tcf transcription is involved in the development of macroscopic tumors in the colon of ApcMin/+ mice.

T. Oyama, Y. Yamada, K. Hata, H. Tomita, A. Hirata, H. Sheng, A. Hara, H. Aoki, T. Kunisada, S. Yamashita, et al. (2008)
Carcinogenesis 29, 666-672
 |  Abstract »  |  Full Text »  |  PDF »

Reduced susceptibility of muscle-specific insulin receptor knockout mice to colon carcinogenesis.

K. N. Ealey, S. Lu, D. Lau, and M. C. Archer (2008)
Am J Physiol Gastrointest Liver Physiol 294, G679-G686
 |  Abstract »  |  Full Text »  |  PDF »

Interleukin-6 and cachexia in ApcMin/+ mice.

K. A. Baltgalvis, F. G. Berger, M. M. O. Pena, J. M. Davis, S. J. Muga, and J. A. Carson (2008)
Am J Physiol Regulatory Integrative Comp Physiol 294, R393-R401
 |  Abstract »  |  Full Text »  |  PDF »

Mast cells are an essential hematopoietic component for polyp development.

E. Gounaris, S. E. Erdman, C. Restaino, M. F. Gurish, D. S. Friend, F. Gounari, D. M. Lee, G. Zhang, J. N. Glickman, K. Shin, et al. (2007)
PNAS 104, 19977-19982
 |  Abstract »  |  Full Text »  |  PDF »

Inhibition of Intestinal Polyposis with Reduced Angiogenesis in ApcMin/+ Mice Due to Decreases in c-Myc Expression.

K. Yekkala and T. A. Baudino (2007)
Mol. Cancer Res. 5, 1296-1303
 |  Abstract »  |  Full Text »  |  PDF »

Heterozygous disruption of the PTEN promotes intestinal neoplasia in APCmin/+ mouse: roles of osteopontin.

J. Shao, M.K. Washington, R. Saxena, and H. Sheng (2007)
Carcinogenesis 28, 2476-2483
 |  Abstract »  |  Full Text »  |  PDF »

Mild Depletion of Dietary Folate Combined with Other B Vitamins Alters Multiple Components of the Wnt Pathway in Mouse Colon.

Z. Liu, S.-W. Choi, J. W. Crott, M. K. Keyes, H. Jang, D. E. Smith, M. Kim, P. W. Laird, R. Bronson, and J. B. Mason (2007)
J. Nutr. 137, 2701-2708
 |  Abstract »  |  Full Text »  |  PDF »

Mouse Model of Colonic Adenoma-Carcinoma Progression Based on Somatic Apc Inactivation.

T. Hinoi, A. Akyol, B. K. Theisen, D. O. Ferguson, J. K. Greenson, B. O. Williams, K. R. Cho, and E. R. Fearon (2007)
Cancer Res. 67, 9721-9730
 |  Abstract »  |  Full Text »  |  PDF »

The genetics of hereditary colon cancer.

A. K. Rustgi (2007)
Genes & Dev. 21, 2525-2538
 |  Abstract »  |  Full Text »  |  PDF »

Adenomatous polyposis coli (APC): a multi-functional tumor suppressor gene.

K. Aoki and M. M. Taketo (2007)
J. Cell Sci. 120, 3327-3335
 |  Abstract »  |  Full Text »  |  PDF »

APC mutations lead to cytokinetic failures in vitro and tetraploid genotypes in Min mice.

C. M. Caldwell, R. A. Green, and K. B. Kaplan (2007)
J. Cell Biol. 178, 1109-1120
 |  Abstract »  |  Full Text »  |  PDF »

Haploinsufficiency of Kruppel-Like Factor 4 Promotes Adenomatous Polyposis Coli Dependent Intestinal Tumorigenesis.

A. M. Ghaleb, B. B. McConnell, M. O. Nandan, J. P. Katz, K. H. Kaestner, and V. W. Yang (2007)
Cancer Res. 67, 7147-7154
 |  Abstract »  |  Full Text »  |  PDF »

Regulation of Spontaneous Intestinal Tumorigenesis Through the Adaptor Protein MyD88.

S. Rakoff-Nahoum and R. Medzhitov (2007)
Science 317, 124-127
 |  Abstract »  |  Full Text »  |  PDF »

From the Cover: Inhibition of VEGF-A prevents the angiogenic switch and results in increased survival of Apc+/min mice.

N. Korsisaari, I. M. Kasman, W. F. Forrest, N. Pal, W. Bai, G. Fuh, F. V. Peale, R. Smits, and N. Ferrara (2007)
PNAS 104, 10625-10630
 |  Abstract »  |  Full Text »  |  PDF »

Development of Gastric Tumors in ApcMin/+ Mice by the Activation of the {beta}-Catenin/Tcf Signaling Pathway.

H. Tomita, Y. Yamada, T. Oyama, K. Hata, Y. Hirose, A. Hara, T. Kunisada, Y. Sugiyama, Y. Adachi, H. Linhart, et al. (2007)
Cancer Res. 67, 4079-4087
 |  Abstract »  |  Full Text »  |  PDF »

A target-selected Apc-mutant rat kindred enhances the modeling of familial human colon cancer.

J. M. Amos-Landgraf, L. N. Kwong, C. M. Kendziorski, M. Reichelderfer, J. Torrealba, J. Weichert, J. D. Haag, K.-S. Chen, J. L. Waller, M. N. Gould, et al. (2007)
PNAS 104, 4036-4041
 |  Abstract »  |  Full Text »  |  PDF »

Serial analysis of chromatin occupancy identifies beta-catenin target genes in colorectal carcinoma cells.

G. S. Yochum, S. McWeeney, V. Rajaraman, R. Cleland, S. Peters, and R. H. Goodman (2007)
PNAS 104, 3324-3329
 |  Abstract »  |  Full Text »  |  PDF »

Breast Cancer: Should Gastrointestinal Bacteria Be on Our Radar Screen?.

V. P. Rao, T. Poutahidis, J. G. Fox, and S. E. Erdman (2007)
Cancer Res. 67, 847-850
 |  Abstract »  |  Full Text »  |  PDF »

Loss of APC induces polyploidy as a result of a combination of defects in mitosis and apoptosis.

D. Dikovskaya, D. Schiffmann, I. P. Newton, A. Oakley, K. Kroboth, O. Sansom, T. J. Jamieson, V. Meniel, A. Clarke, and I. S. Nathke (2007)
J. Cell Biol. 176, 183-195
 |  Abstract »  |  Full Text »  |  PDF »

Frequent Mutation of Apc Gene in Rat Colon Tumors and Mucin-Depleted Foci, Preneoplastic Lesions in Experimental Colon Carcinogenesis.

A. P. Femia, P. Dolara, A. Giannini, M. Salvadori, A. Biggeri, and G. Caderni (2007)
Cancer Res. 67, 445-449
 |  Abstract »  |  Full Text »  |  PDF »

Sphingosine-1-phosphate lyase potentiates apoptosis via p53- and p38-dependent pathways and is down-regulated in colon cancer.

B. Oskouian, P. Sooriyakumaran, A. D. Borowsky, A. Crans, L. Dillard-Telm, Y. Y. Tam, P. Bandhuvula, and J. D. Saba (2006)
PNAS 103, 17384-17389
 |  Abstract »  |  Full Text »  |  PDF »

Cancer chemoprevention of intestinal polyposis in ApcMin/+ mice by sulforaphane, a natural product derived from cruciferous vegetable.

R. Hu, T. O. Khor, G. Shen, W.-S. Jeong, V. Hebbar, C. Chen, C. Xu, B. Reddy, K. Chada, and A.-N. T. Kong (2006)
Carcinogenesis 27, 2038-2046
 |  Abstract »  |  Full Text »  |  PDF »

Inhibiting vascular endothelial growth factor receptor-2 signaling reduces tumor burden in the ApcMin/+ mouse model of early intestinal cancer.

R.A. Goodlad, A.J. Ryan, S.R. Wedge, I.T. Pyrah, D. Alferez, R. Poulsom, N.R. Smith, N. Mandir, A.J. Watkins, and R.W. Wilkinson (2006)
Carcinogenesis 27, 2133-2139
 |  Abstract »  |  Full Text »  |  PDF »

Adenomatous polyposis coli determines sensitivity to histone deacetylase inhibitor-induced apoptosis in colon cancer cells..

X. Huang and B. Guo (2006)
Cancer Res. 66, 9245-9251
 |  Abstract »  |  Full Text »  |  PDF »

Smad3 Deficiency Promotes Tumorigenesis in the Distal Colon of ApcMin/+ Mice..

N. M. Sodir, X. Chen, R. Park, A. E. Nickel, P. S. Conti, R. Moats, J. R. Bading, D. Shibata, and P. W. Laird (2006)
Cancer Res. 66, 8430-8438
 |  Abstract »  |  Full Text »  |  PDF »

Disruption of early proximodistal patterning and AVE formation in Apc mutants.

C. Chazaud and J. Rossant (2006)
Development 133, 3379-3387
 |  Abstract »  |  Full Text »  |  PDF »

Protein Kinase C {alpha} but not PKC{zeta} Suppresses Intestinal Tumor Formation in ApcMin/+ Mice..

H. Oster and M. Leitges (2006)
Cancer Res. 66, 6955-6963
 |  Abstract »  |  Full Text »  |  PDF »

Stage matters: choosing relevant model systems to address hypotheses in diet and cancer chemoprevention research.

J. I. Fenton and N. G. Hord (2006)
Carcinogenesis 27, 893-902
 |  Abstract »  |  Full Text »  |  PDF »

Bone marrow-derived cells fuse with normal and transformed intestinal stem cells.

A. Z. Rizvi, J. R. Swain, P. S. Davies, A. S. Bailey, A. D. Decker, H. Willenbring, M. Grompe, W. H. Fleming, and M. H. Wong (2006)
PNAS 103, 6321-6325
 |  Abstract »  |  Full Text »  |  PDF »

Possible Involvement of Hyperlipidemia in Increasing Risk of Colorectal Tumor Development in Human Familial Adenomatous Polyposis.

M. Mutoh, T. Akasu, M. Takahashi, N. Niho, T. Yoshida, T. Sugimura, and K. Wakabayashi (2006)
Jpn. J. Clin. Oncol. 36, 166-171
 |  Abstract »  |  Full Text »  |  PDF »

EphB/EphrinB Receptors and Wnt Signaling in Colorectal Cancer.

H. Clevers and E. Batlle (2006)
Cancer Res. 66, 2-5
 |  Abstract »  |  Full Text »  |  PDF »

Proinflammatory CD4+CD45RBhi Lymphocytes Promote Mammary and Intestinal Carcinogenesis in ApcMin/+ Mice.

V. P. Rao, T. Poutahidis, Z. Ge, P. R. Nambiar, B. H. Horwitz, J. G. Fox, and S. E. Erdman (2006)
Cancer Res. 66, 57-61
 |  Abstract »  |  Full Text »  |  PDF »

Tumor suppression and normal aging in mice with constitutively high p53 activity.

S. M. Mendrysa, K. A. O'Leary, M. K. McElwee, J. Michalowski, R. N. Eisenman, D. A. Powell, and M. E. Perry (2006)
Genes & Dev. 20, 16-21
 |  Abstract »  |  Full Text »  |  PDF »

Impact of Physical Activity on Intestinal Cancer Development in Mice.

L. Basterfield, J. M.H.M. Reul, and J. C. Mathers (2005)
J. Nutr. 135, 3002S-3008S
 |  Abstract »  |  Full Text »  |  PDF »

Critical Function for ADAM9 in Mouse Prostate Cancer.

L. Peduto, V. E. Reuter, D. R. Shaffer, H. I. Scher, and C. P. Blobel (2005)
Cancer Res. 65, 9312-9319
 |  Abstract »  |  Full Text »  |  PDF »

The Threshold Level of Adenomatous Polyposis Coli Protein for Mouse Intestinal Tumorigenesis.

Q. Li, T.-o Ishikawa, M. Oshima, and M. M. Taketo (2005)
Cancer Res. 65, 8622-8627
 |  Abstract »  |  Full Text »  |  PDF »

N-Ethyl-N-Nitrosourea Mutagenesis: Boarding the Mouse Mutant Express.

S. P. Cordes (2005)
Microbiol. Mol. Biol. Rev. 69, 426-439
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Leptin stimulates the proliferation of human colon cancer cells in vitro but does not promote the growth of colon cancer xenografts in nude mice or intestinal tumorigenesis in ApcMin/+ mice.

T Aparicio, L Kotelevets, A Tsocas, J-P Laigneau, I Sobhani, E Chastre, and T Lehy (2005)
Gut 54, 1136-1145
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Potent Modulation of Intestinal Tumorigenesis in Apcmin/+ Mice by the Polyamine Catabolic Enzyme Spermidine/Spermine N1-acetyltransferase.

J. M. Tucker, J. T. Murphy, N. Kisiel, P. Diegelman, K. W. Barbour, C. Davis, M. Medda, L. Alhonen, J. Janne, D. L. Kramer, et al. (2005)
Cancer Res. 65, 5390-5398
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Decreased intestinal polyp multiplicity is related to exercise mode and gender in ApcMin/+ mice.

K. A. Mehl, J. M. Davis, J. M. Clements, F. G. Berger, M. M. Pena, and J. A. Carson (2005)
J Appl Physiol 98, 2219-2225
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CD4+CD25+ Regulatory Lymphocytes Induce Regression of Intestinal Tumors in ApcMin/+ Mice.

S. E. Erdman, J. J. Sohn, V. P. Rao, P. R. Nambiar, Z. Ge, J. G. Fox, and D. B. Schauer (2005)
Cancer Res. 65, 3998-4004
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Non-steroidal anti-inflammatory drugs and colorectal cancer prevention.

S Sangha, M Yao, and M M Wolfe (2005)
Postgrad. Med. J. 81, 223-227
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Defective sister-chromatid cohesion, aneuploidy and cancer predisposition in a mouse model of type II Rothmund-Thomson syndrome.

M. B. Mann, C. A. Hodges, E. Barnes, H. Vogel, T. J. Hassold, and G. Luo (2005)
Hum. Mol. Genet. 14, 813-825
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Modulation of tumor formation and intestinal cell migration by estrogens in the ApcMin/+ mouse model of colorectal cancer.

S. H. Javid, A. E. Moran, A. M. Carothers, M. Redston, and M. M. Bertagnolli (2005)
Carcinogenesis 26, 587-595
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Microcomputed tomography colonography for polyp detection in an in vivo mouse tumor model.

P. J. Pickhardt, R. B. Halberg, A. J. Taylor, B. Y. Durkee, J. Fine, F. T. Lee Jr., and J. P. Weichert (2005)
PNAS 102, 3419-3422
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Concurrent suppression of hyperlipidemia and intestinal polyp formation by NO-1886, increasing lipoprotein lipase activity in Min mice.

N. Niho, M. Mutoh, M. Takahashi, K. Tsutsumi, T. Sugimura, and K. Wakabayashi (2005)
PNAS 102, 2970-2974
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Liver receptor homolog 1 contributes to intestinal tumor formation through effects on cell cycle and inflammation.

K. Schoonjans, L. Dubuquoy, J. Mebis, E. Fayard, O. Wendling, C. Haby, K. Geboes, and J. Auwerx (2005)
PNAS 102, 2058-2062
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The Wnt/{beta}-catenin signaling pathway targets PPAR{gamma} activity in colon cancer cells.

E. A. Jansson, A. Are, G. Greicius, I-C. Kuo, D. Kelly, V. Arulampalam, and S. Pettersson (2005)
PNAS 102, 1460-1465
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Foxl1 is a mesenchymal Modifier of Min in carcinogenesis of stomach and colon.

N. Perreault, S. D. Sackett, J. P. Katz, E. E. Furth, and K. H. Kaestner (2005)
Genes & Dev. 19, 311-315
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Colorectal Cancer Prevention.

E. T. Hawk and B. Levin (2005)
J. Clin. Oncol. 23, 378-391
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Transcriptional Profiles of Intestinal Tumors in ApcMin Mice are Unique from those of Embryonic Intestine and Identify Novel Gene Targets Dysregulated in Human Colorectal Tumors.

T. Reichling, K. H. Goss, D. J. Carson, R. W. Holdcraft, C. Ley-Ebert, D. Witte, B. J. Aronow, and J. Groden (2005)
Cancer Res. 65, 166-176
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Effects of Energy Balance on Cancer in Genetically Altered Mice.

A. C. Patel, N. P. Nunez, S. N. Perkins, J. C. Barrett, and S. D. Hursting (2004)
J. Nutr. 134, 3394S-3398S
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Dietary (n-6) PUFA and Intestinal Tumorigenesis.

J. Whelan and M. F. McEntee (2004)
J. Nutr. 134, 3421S-3426S
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Vitamin D and Colon Carcinogenesis.

D. M. Harris and V. L. W. Go (2004)
J. Nutr. 134, 3463S-3471S
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Tumor-Suppressing Effects of Antioxidants from Tea.

G. A. Orner, W.-M. Dashwood, and R. H. Dashwood (2004)
J. Nutr. 134, 3177S-3178S
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Cyclin D1 Genetic Heterozygosity Regulates Colonic Epithelial Cell Differentiation and Tumor Number in ApcMin Mice.

J. Hulit, C. Wang, Z. Li, C. Albanese, M. Rao, D. Di Vizio, S. Shah, S. W. Byers, R. Mahmood, L. H. Augenlicht, et al. (2004)
Mol. Cell. Biol. 24, 7598-7611
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Commensal Bacteria, Redox Stress, and Colorectal Cancer: Mechanisms and Models.

M. M. Huycke and H. R. Gaskins (2004)
Experimental Biology and Medicine 229, 586-597
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Tumor regionality in the mouse intestine reflects the mechanism of loss of Apc function.

K. M. Haigis, P. D. Hoff, A. White, A. R. Shoemaker, R. B. Halberg, and W. F. Dove (2004)
PNAS 101, 9769-9773
 |  Abstract »  |  Full Text »  |  PDF »

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